Disseminated Superficial Actinic Porokeratosis: A Systematic Treatment Review.

IF 8.6 1区医学 Q1 DERMATOLOGY American Journal of Clinical Dermatology Pub Date : 2024-11-01 DOI:10.1007/s40257-024-00903-x

Stephanie Tan, Ernest Tan

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Abstract

Background: Disseminated superficial actinic porokeratosis (DSAP) is a disorder of keratinization characterised by small, brown plaques with elevated keratotic rims, typically occurring on sun exposed areas. DSAP poses a risk for malignant transformation, emphasising the need for effective management strategies.

Objective: The aim of this study was to review the current reported management options for DSAP.

Methods: This systematic review was based on a comprehensive search of databases (Cochrane, PubMed, Medline, Embase, Emcare, ProQuest, Web of Science, CINAHL) from inception to 15 March 2024. Studies reporting management of DSAP were included irrespective of study design.

Results: Of 923 citations, 61 studies were included, predominantly comprising case reports and retrospective case series. A limited number of randomized and open-label trials were identified. Various treatment modalities were reported, including topical and systemic agents, photodynamic therapy, and laser therapy.

Conclusion: Multiple management options are available for DSAP, including topical and systemic agents, photodynamic therapy and laser treatments. However, these approaches vary in their balance between efficacy and toxicity. Currently, there is a paucity of high-quality clinical trial data to guide treatment decisions. Further studies are required to determine the most effective and safe management strategies for DSAP. PROSPERO REGISTRATION: CRD42024514558.

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播散性浅表性角化病：系统治疗回顾。

背景：播散性表浅光化性角化病（DSAP）是一种角质化障碍性疾病，其特征为小的棕色斑块，角化边缘隆起，通常发生在阳光暴露的部位。DSAP 有恶变的风险，因此需要采取有效的管理策略：本研究旨在回顾目前报道的 DSAP 的治疗方案：本系统综述基于从开始到 2024 年 3 月 15 日对数据库（Cochrane、PubMed、Medline、Embase、Emcare、ProQuest、Web of Science、CINAHL）的全面检索。无论研究设计如何，均纳入了报告DSAP管理情况的研究：结果：在 923 篇引文中，共纳入 61 篇研究，主要包括病例报告和回顾性系列病例。此外，还发现了数量有限的随机试验和开放标签试验。报告了各种治疗方式，包括局部和全身用药、光动力疗法和激光疗法：结论：DSAP 有多种治疗方案可供选择，包括局部和全身用药、光动力疗法和激光治疗。然而，这些方法在疗效和毒性之间的平衡各不相同。目前，缺乏高质量的临床试验数据来指导治疗决策。要确定 DSAP 最有效、最安全的治疗策略，还需要进一步的研究。PROCERMO注册：CRD42024514558。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Journal of Clinical Dermatology 医学-皮肤病学

CiteScore

15.20

自引率

2.70%

发文量

审稿时长

>12 weeks

期刊介绍： The American Journal of Clinical Dermatology is dedicated to evidence-based therapy and effective patient management in dermatology. It publishes critical review articles and clinically focused original research covering comprehensive aspects of dermatological conditions. The journal enhances visibility and educational value through features like Key Points summaries, plain language summaries, and various digital elements, ensuring accessibility and depth for a diverse readership.