Experimental Manipulation of the Bilateral Posterior Parietal Cortex Strengthens Associative Memory in Healthy Participants: A Continuous Theta-burst Stimulation.

IF 3.1 3区 医学 Q2 NEUROSCIENCES Journal of Cognitive Neuroscience Pub Date : 2024-11-01 DOI:10.1162/jocn_a_02273
Lulu Cheng, Xinzhao Li, Zeqi Hao, Jing Li, Mengqi Zhao, Linlin Zhan, Mengting Li, Haiyan Gu, Xize Jia
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Abstract

To test whether targeting left and right posterior parietal cortex (PPC) with continuous theta-burst stimulation (cTBS) in healthy adults would strengthen associative memory (AM) performance. This study consisted of two experiments (a behavioral experiment and a formal experiment during each of the two experimental sessions). In Experiment 1, 18 adults (one male, age = 22.83 ± 3.92 years) were included in the behavioral phase and 18 adults (seven males, age = 40.11 ± 12.27 years) in the stimulation phase. There were 120 neutral facial images paired with 120 two-character nouns and then divided into six test versions (10 male faces and 10 female faces paired with 20 different nouns were considered as one version). In the behavioral experiment, participants were tested by six-version tests to assess memory materials, and in the formal experiment, participants' face-word AM performance was measured by certified tests based on a cued recall paradigm. Furthermore, 30 adults (seven males, age = 20.97 ± 1.85 years) and 15 adults (five males, age = 22.27 ± 1.29 years) participated in Experiment 2, respectively. Stimuli and procedure were the same as in Experiment 1, but the AM test was based on a forced-choice paradigm. Experiment 1 did not yield anticipated outcomes; Experiment 2 showed that cTBS of left and right PPC strengthened the AM performance compared with the control condition. In conclusion, cTBS to left and right PPC improved AM in healthy adults, which provided further experimental evidence for strengthening AM by cTBS.

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实验性操纵双侧顶叶后皮层可增强健康参与者的联想记忆:连续θ-猝发刺激
目的:测试对健康成年人的左右顶叶后皮层(PPC)进行连续θ-脉冲刺激(cTBS)是否会加强联想记忆(AM)的表现。本研究包括两个实验(行为实验和正式实验)。在实验 1 中,18 名成年人(1 名男性,年龄 = 22.83 ± 3.92 岁)参加了行为实验,18 名成年人(7 名男性,年龄 = 40.11 ± 12.27 岁)参加了刺激实验。共有 120 张中性人脸图像与 120 个双字符名词配对,然后分为六个测试版本(10 张男性人脸和 10 张女性人脸与 20 个不同名词配对为一个版本)。在行为实验中,受试者通过六个版本的测试来评估记忆材料;在正式实验中,受试者的面孔-词AM表现则通过基于诱导回忆范式的认证测试来测量。此外,30名成人(7名男性,年龄=20.97±1.85岁)和15名成人(5名男性,年龄=22.27±1.29岁)分别参加了实验2。刺激物和程序与实验 1 相同,但 AM 测试采用了强迫选择范式。实验 1 并未得出预期结果;实验 2 显示,与对照组相比,cTBS 对左侧和右侧 PPC 的刺激增强了 AM 表现。总之,对左右大脑皮层进行 cTBS 可改善健康成年人的 AM,这为通过 cTBS 加强 AM 提供了进一步的实验证据。
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来源期刊
Journal of Cognitive Neuroscience
Journal of Cognitive Neuroscience 医学-神经科学
CiteScore
5.30
自引率
3.10%
发文量
151
审稿时长
3-8 weeks
期刊介绍: Journal of Cognitive Neuroscience investigates brain–behavior interaction and promotes lively interchange among the mind sciences.
期刊最新文献
Attentional Refreshing in Working Memory and Its Interplay with Long-term Memory: A Behavioral and EEG Study. Experimental Manipulation of the Bilateral Posterior Parietal Cortex Strengthens Associative Memory in Healthy Participants: A Continuous Theta-burst Stimulation. Similarity Distractors Increase the Burden of Chinese Character Selection and Updating in Working Memory. Theta Transcranial Alternating Current Stimulation Is Not Effective in Improving Working Memory Performance. Movement Strategy Moderates the Effect of Spatially Congruent Cues on the Stability of Rhythmic Bimanual Finger Movements.
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