Multifunctional injectable oxidized sodium alginate/carboxymethyl chitosan hydrogel for rapid hemostasis.

IF 5.4 2区 医学 Q1 BIOPHYSICS Colloids and Surfaces B: Biointerfaces Pub Date : 2024-10-29 DOI:10.1016/j.colsurfb.2024.114346
Xuanyu Liu, Junjie Hu, Yinchun Hu, Yeying Liu, Yan Wei, Di Huang
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Abstract

Uncontrolled bleeding from incompressible or irregularly shaped wounds is a major factor in the death of people in the battlefield or surgery process. Ideal rapid hemostatic materials should have the performance of rapid hemostasis and at the same time can be applied to a variety of complex wound trauma types, in addition, excellent antimicrobial properties, adhesion, biocompatibility, degradation, and the non-toxicity of degradation products are also necessary, but there are fewer hemostatic materials that meet these requirements. Herein, we prepared an injectable hemostatic hydrogel based on the natural products sodium alginate (SA) and carboxymethyl chitosan (CMC). Oxidized sodium alginate (OSA) was prepared by the oxidation reaction of NaIO4 with SA, and OSA with aldehyde group was mixed with CMC with amino group to rapidly form an in situ injectable hemostatic hydrogel (OSA/CMC) by the Schiff base reaction. OSA/CMC hydrogel exhibited excellent antimicrobial and adhesion properties by the Schiff base reaction. In addition, OSA/CMC hydrogel directly activate the endogenous coagulation pathway through the synergistic effect of OSA, CMC to enhance the hemostatic effect. The results of in vivo hemostasis study showed that OSA/CMC hydrogel significantly accelerated hemostasis and reduced blood loss in liver hemorrhage model and tail amputation model. Therefore, OSA/CMC hydrogel is expected to be a potential material in the direction of rapid clinical hemostasis due to its good adhesion properties, antimicrobial properties, biocompatibility, blood compatibility, and efficient rapid hemostasis.

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用于快速止血的多功能注射用氧化海藻酸钠/羧甲基壳聚糖水凝胶。
在战场或手术过程中,不可压缩或形状不规则的伤口无法控制的出血是导致人员死亡的主要因素。理想的快速止血材料应具有快速止血的性能,同时能适用于各种复杂的创伤类型,此外还需要具有优良的抗菌性、粘附性、生物相容性、降解性和降解产物的无毒性,但目前能满足这些要求的止血材料较少。在此,我们以天然产物海藻酸钠(SA)和羧甲基壳聚糖(CMC)为基础制备了一种可注射止血水凝胶。利用 NaIO4 与海藻酸钠的氧化反应制备氧化海藻酸钠(OSA),并将带有醛基的 OSA 与带有氨基的 CMC 混合,通过席夫碱反应快速形成原位注射止血水凝胶(OSA/CMC)。通过席夫碱反应,OSA/CMC 水凝胶具有优异的抗菌性和粘附性。此外,OSA/CMC 水凝胶还能通过 OSA、CMC 的协同作用直接激活内源性凝血途径,从而增强止血效果。体内止血研究结果表明,OSA/CMC 水凝胶在肝脏出血模型和断尾模型中能明显加快止血速度,减少失血量。因此,OSA/CMC 水凝胶具有良好的粘附性、抗菌性、生物相容性、血液相容性和高效快速止血等特性,有望成为临床快速止血方向的潜在材料。
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来源期刊
Colloids and Surfaces B: Biointerfaces
Colloids and Surfaces B: Biointerfaces 生物-材料科学:生物材料
CiteScore
11.10
自引率
3.40%
发文量
730
审稿时长
42 days
期刊介绍: Colloids and Surfaces B: Biointerfaces is an international journal devoted to fundamental and applied research on colloid and interfacial phenomena in relation to systems of biological origin, having particular relevance to the medical, pharmaceutical, biotechnological, food and cosmetic fields. Submissions that: (1) deal solely with biological phenomena and do not describe the physico-chemical or colloid-chemical background and/or mechanism of the phenomena, and (2) deal solely with colloid/interfacial phenomena and do not have appropriate biological content or relevance, are outside the scope of the journal and will not be considered for publication. The journal publishes regular research papers, reviews, short communications and invited perspective articles, called BioInterface Perspectives. The BioInterface Perspective provide researchers the opportunity to review their own work, as well as provide insight into the work of others that inspired and influenced the author. Regular articles should have a maximum total length of 6,000 words. In addition, a (combined) maximum of 8 normal-sized figures and/or tables is allowed (so for instance 3 tables and 5 figures). For multiple-panel figures each set of two panels equates to one figure. Short communications should not exceed half of the above. It is required to give on the article cover page a short statistical summary of the article listing the total number of words and tables/figures.
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