Efficacy and safety of narrowband ultraviolet B phototherapy for prurigo nodularis: a tertiary center experience.

IF 2.6 4区医学 Q2 DERMATOLOGY Anais brasileiros de dermatologia Pub Date : 2024-10-31 DOI:10.1016/j.abd.2024.02.007

Esra Agaoglu, Hilal Kaya Erdogan, Ersoy Acer, Zeynep Nurhan Saracoglu

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Abstract

Background: Prurigo nodularis is a chronic pruritic dermatosis and narrowband-UVB (NB-UVB) phototherapy is considered an effective and safe treatment option in patients with multiple comorbidities.

Objective: In this study, the authors aimed to evaluate the efficacy and safety of NB-UVB phototherapy in the management of prurigo nodularis and to compare response rates according to lesions localization.

Methods: Thirty prurigo nodularis patients who had been treated with NB-UVB phototherapy were included in this study. The data for this study were retrieved retrospectively from patient follow-up forms in the phototherapy unit.

Results: NB-UVB phototherapy led to a complete response (CR) in 24 (80%) patients while partial response (PR) was achieved in 6 (20%) patients. Regarding prurigo nodularis localization, the CR rate was statistically higher in those with diffuse and central involvement (p < 0.05). Erythema and/or pruritus were observed in 4 (13.3%) patients with prurigo nodularis.

Study limitations: This study is limited because it is single-centered and has a retrospective design.

Conclusions: NB-UVB phototherapy is an effective and safe treatment option for prurigo nodularis patients especially those with multiple comorbidities and using several medications. Patients with diffuse and central involvement may respond better to phototherapy than those with peripheral involvement.

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窄带紫外线 B 光疗法治疗结节性瘙痒症的有效性和安全性：一家三级医疗中心的经验。

背景：结节性瘙痒症是一种慢性瘙痒性皮肤病，窄带紫外线（NB-UVB）光疗被认为是一种有效且安全的治疗方法，适用于有多种并发症的患者：在这项研究中，作者旨在评估 NB-UVB 光疗在治疗结节性瘙痒症中的有效性和安全性，并根据皮损定位比较反应率：本研究纳入了 30 名接受过 NB-UVB 光疗的结节性瘙痒症患者。研究数据来自光疗室的患者随访表：结果：24 名患者（80%）通过 NB-UVB 光疗获得了完全应答（CR），6 名患者（20%）获得了部分应答（PR）。关于结节性瘙痒症的定位，从统计学角度看，弥漫性和中心性受累者的 CR 率较高（P 研究局限性：本研究的局限性在于它是一项单一中心的回顾性研究：NB-UVB光疗是结节性瘙痒症患者（尤其是患有多种并发症和使用多种药物的患者）的一种有效、安全的治疗方法。与周围受累的患者相比，弥漫性和中心受累的患者对光疗的反应可能更好。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Anais brasileiros de dermatologia DERMATOLOGY-

CiteScore

2.40

自引率

0.00%

发文量

184

审稿时长

32 days

期刊介绍： The journal is published bimonthly and is devoted to the dissemination of original, unpublished technical-scientific study, resulting from research or reviews of dermatological topics and related matters. Exchanges with other publications may be accepted.