The risk of kidney dysfunction in metabolically healthy/unhealthy population with normal weight or overweight/obesity: a systematic review and meta-analysis.

Majid Valizadeh, Amirhossein Ramezani Ahmadi, Faeze Abbaspour, Ali Valizadeh, Ahad Hasan Syed Hasani, Seyed Mohammadmisagh Moteshakereh, Mohammad Nikoohemmat, Behnaz Abiri
{"title":"The risk of kidney dysfunction in metabolically healthy/unhealthy population with normal weight or overweight/obesity: a systematic review and meta-analysis.","authors":"Majid Valizadeh, Amirhossein Ramezani Ahmadi, Faeze Abbaspour, Ali Valizadeh, Ahad Hasan Syed Hasani, Seyed Mohammadmisagh Moteshakereh, Mohammad Nikoohemmat, Behnaz Abiri","doi":"10.1007/s40519-024-01697-x","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Chronic kidney disease (CKD) is a major global health concern with increasing prevalence and associated complications. Obesity and obesity-related metabolic disorders have been linked to chronic kidney disease (CKD), although the evidence is still inconsistent. To investigate the relationship between different obesity phenotypes and the risk of CKD, we conducted a systematic review and meta-analysis.</p><p><strong>Method: </strong>We conducted a comprehensive search of databases for all relevant studies up to February 2024, without imposing a specific start date, for observational studies assessing the relationship between obesity phenotypes and incident kidney dysfunction. We used fixed and random effects models for the meta-analysis, subgroup analyses were carried out to explore heterogeneity, and Egger's and Begg's tests were used to assess publication bias.</p><p><strong>Result: </strong>This meta-analysis included 13 eligible observational studies with 492,829 participants. Pooling the studies regardless of the effect measure showed that individuals with metabolically unhealthy normal weight (MUNW) (ES = 1.58, 95% CI = 1.43-1.76), metabolically healthy obese (MHO) (ES = 1.20, 95% CI = 1.06-1.34), and metabolically unhealthy obese (MUO) (ES = 1.90, 95% CI = 1.63-2.20) phenotypes had a significantly increased risk for kidney dysfunction (KD) events. On the other hand, MUOW individuals did not significantly correlate with risk of CKD (ES = 1.63, 95% CI = 0.97-2.23) compared to the MHNW phenotype.</p><p><strong>Conclusion: </strong>Healthy overweight and obese individuals had higher risk for the incident KD events; refuting the notion that metabolically healthy overweight and obese phenotypes are benign conditions.</p><p><strong>Level of evidence: </strong>III Evidence obtained from well-designed cohort or cross-sectional studies.</p>","PeriodicalId":11391,"journal":{"name":"Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity","volume":null,"pages":null},"PeriodicalIF":2.9000,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11531429/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s40519-024-01697-x","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PSYCHIATRY","Score":null,"Total":0}
引用次数: 0

Abstract

Background: Chronic kidney disease (CKD) is a major global health concern with increasing prevalence and associated complications. Obesity and obesity-related metabolic disorders have been linked to chronic kidney disease (CKD), although the evidence is still inconsistent. To investigate the relationship between different obesity phenotypes and the risk of CKD, we conducted a systematic review and meta-analysis.

Method: We conducted a comprehensive search of databases for all relevant studies up to February 2024, without imposing a specific start date, for observational studies assessing the relationship between obesity phenotypes and incident kidney dysfunction. We used fixed and random effects models for the meta-analysis, subgroup analyses were carried out to explore heterogeneity, and Egger's and Begg's tests were used to assess publication bias.

Result: This meta-analysis included 13 eligible observational studies with 492,829 participants. Pooling the studies regardless of the effect measure showed that individuals with metabolically unhealthy normal weight (MUNW) (ES = 1.58, 95% CI = 1.43-1.76), metabolically healthy obese (MHO) (ES = 1.20, 95% CI = 1.06-1.34), and metabolically unhealthy obese (MUO) (ES = 1.90, 95% CI = 1.63-2.20) phenotypes had a significantly increased risk for kidney dysfunction (KD) events. On the other hand, MUOW individuals did not significantly correlate with risk of CKD (ES = 1.63, 95% CI = 0.97-2.23) compared to the MHNW phenotype.

Conclusion: Healthy overweight and obese individuals had higher risk for the incident KD events; refuting the notion that metabolically healthy overweight and obese phenotypes are benign conditions.

Level of evidence: III Evidence obtained from well-designed cohort or cross-sectional studies.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
体重正常或超重/肥胖的代谢健康/不健康人群出现肾功能障碍的风险:系统综述和荟萃分析。
背景:慢性肾脏病(CKD)是全球关注的主要健康问题,其发病率和相关并发症不断增加。肥胖和肥胖相关的代谢紊乱与慢性肾脏病(CKD)有关,但证据仍不一致。为了研究不同肥胖表型与 CKD 风险之间的关系,我们进行了一项系统回顾和荟萃分析:我们在数据库中全面检索了截至 2024 年 2 月的所有相关研究,未规定具体的开始日期,以评估肥胖表型与肾功能障碍事件之间关系的观察性研究。我们在荟萃分析中使用了固定效应和随机效应模型,进行了亚组分析以探讨异质性,并使用Egger检验和Begg检验来评估发表偏倚:这项荟萃分析包括 13 项符合条件的观察性研究,共有 492 829 人参与。将所有研究(无论效果测量值如何)汇总后发现,代谢不健康正常体重(MUNW)(ES = 1.58,95% CI = 1.43-1.76)、代谢健康肥胖(MHO)(ES = 1.20,95% CI = 1.06-1.34)和代谢不健康肥胖(MUO)(ES = 1.90,95% CI = 1.63-2.20)表型的个体发生肾功能障碍(KD)事件的风险显著增加。另一方面,与 MHNW 表型相比,MUOW 与 CKD 风险(ES = 1.63,95% CI = 0.97-2.23)并无明显关联:结论:健康的超重和肥胖者发生 KD 事件的风险较高;驳斥了代谢健康的超重和肥胖表型是良性疾病的观点:III 证据来自设计良好的队列或横断面研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
CiteScore
6.50
自引率
10.30%
发文量
170
审稿时长
>12 weeks
期刊介绍: Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity is a scientific journal whose main purpose is to create an international forum devoted to the several sectors of eating disorders and obesity and the significant relations between them. The journal publishes basic research, clinical and theoretical articles on eating disorders and weight-related problems: anorexia nervosa, bulimia nervosa, subthreshold eating disorders, obesity, atypical patterns of eating behaviour and body weight regulation in clinical and non-clinical populations.
期刊最新文献
Transcultural adaptation and validation of the Eating Self-Efficacy Brief Scale (ESEBS): the Brazilian version. The risk of kidney dysfunction in metabolically healthy/unhealthy population with normal weight or overweight/obesity: a systematic review and meta-analysis. Correction: Optimising healthcare transition of adolescents and young adults to adult care: a perspective statement of the Italian Society of Obesity. Multidimensional perfectionism and orthorexia: a systematic review and meta-analysis. Adverse childhood experiences and profiles of healthy orthorexia versus orthorexia nervosa: towards an explanatory model of orthorexia as a multidimensional eating style.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1