Plasma N-terminal pro-B-type natriuretic peptide and urinary aldosterone-to-creatinine ratio in healthy Chihuahuas.

IF 2.3 2区 农林科学 Q1 VETERINARY SCIENCES BMC Veterinary Research Pub Date : 2024-11-01 DOI:10.1186/s12917-024-04344-w
Alberto Galizzi, Greta Dossi, Paola Pocar, Vitaliano Borromeo, Chiara Locatelli
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Abstract

Background: Chihuahua represents an increasingly widespread breed predisposed to cardiac disease. N-terminal pro-B-type natriuretic peptide (NT-proBNP) might be a useful point-of-care biomarker for dogs suspected of having heart disease, but breed differences have been reported. The urinary aldosterone-to-creatinine ratio (UAldo: C) appears to be a good indicator of renin-angiotensin-aldosterone system activity in dogs, but Chihuahuas showed significantly higher UAldo: C than other breeds. The objective of this study was to assess preliminary breed-specific reference intervals for NT-proBNP and UAldo: C in healthy Chihuahuas and evaluate sex differences in these parameters.

Results: Forty-three healthy Chihuahuas dogs were enrolled. The median NT-proBNP was 347 (125-515) pmol/L, and the median UAldo: C was 2.59 (1.57-4.61) µg/g. The NT-proBNP reference interval was 125 (90% CI 125-125) - 2121.4 (90% CI 941.6-2248) pmol/L. 91% of the Chihuahuas were below the nonbreed-specific cut-off (900 pmol/L). The UAldo: C reference interval was 0.6 (90% CI 0.5-0.9) - 16.8 (90% CI 10.9-27.4) µg/g. No significant sex differences in NT-proBNP or UAldo: C were found.

Conclusions: The median value, interindividual coefficient of variation and reference interval of NT-proBNP were in line with those reported for other small breeds. In contrast to previous studies, no sex differences in NT-proBNP were detected. As previously suggested, Chihuahuas seem to be characterized by higher values of UAldo: C than other breeds.

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健康吉娃娃犬的血浆 N 端前 B 型钠利尿肽和尿液中醛固酮与肌酐的比率。
背景:吉娃娃犬是越来越普遍的易患心脏病的犬种。N 端前 B 型钠尿肽(NT-proBNP)可能是疑似患有心脏病的狗的一种有用的护理点生物标志物,但有报道称犬种之间存在差异。尿醛固酮与肌酐的比率(UAldo: C)似乎是狗体内肾素-血管紧张素-醛固酮系统活性的良好指标,但吉娃娃的 UAldo: C 明显高于其他品种。本研究的目的是评估健康吉娃娃犬 NT-proBNP 和 UAldo: C 的初步品种特异性参考区间,并评估这些参数的性别差异:结果:43 只健康的吉娃娃犬参加了研究。NT-proBNP 的中位数为 347 (125-515) pmol/L,UAldo: C 的中位数为 2.59 (1.57-4.61) µg/g。NT-proBNP 参考区间为 125(90% CI 125-125)-2121.4(90% CI 941.6-2248)pmol/L。91%的吉娃娃犬低于非品种特异性临界值(900 pmol/L)。UAldo:C 参考区间为 0.6(90% CI 0.5-0.9)-16.8(90% CI 10.9-27.4)微克/克。NT-proBNP和UAldo: C没有发现明显的性别差异:结论:NT-proBNP的中值、个体间变异系数和参考区间与其他小型犬种的报告一致。与之前的研究相比,NT-proBNP 没有发现性别差异。正如之前所说,吉娃娃犬的 UAldo: C 值似乎高于其他犬种。
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来源期刊
BMC Veterinary Research
BMC Veterinary Research VETERINARY SCIENCES-
CiteScore
4.80
自引率
3.80%
发文量
420
审稿时长
3-6 weeks
期刊介绍: BMC Veterinary Research is an open access, peer-reviewed journal that considers articles on all aspects of veterinary science and medicine, including the epidemiology, diagnosis, prevention and treatment of medical conditions of domestic, companion, farm and wild animals, as well as the biomedical processes that underlie their health.
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