A transdiagnostic approach of negative symptoms in psychiatric disorders: replication of a two-factor structure in major depressive disorder and bipolar disorder.

IF 3.5 3区 医学 Q1 CLINICAL NEUROLOGY European Archives of Psychiatry and Clinical Neuroscience Pub Date : 2024-11-02 DOI:10.1007/s00406-024-01934-5
Shuai-Biao Li, Jian-Biao Zhang, Chao Liu, Ling-Ling Wang, Hui-Xin Hu, Min-Yi Chu, Yi Wang, Qin-Yu Lv, Simon S Y Lui, Zheng-Hui Yi, Raymond C K Chan
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Abstract

Recent empirical findings suggest that negative symptoms are not limited to schizophrenia (SCZ) but also present in major depressive disorder (MDD) and bipolar disorder (BD) patients. Although SCZ patients generally showed a latent structure comprising the motivation and pleasure (MAP) and expression (EXP) factors, it remains unclear whether the same latent structure exists in MDD and BD patients. We administered the Clinical Assessment Interview for Negative Symptoms (CAINS) and the Brief Negative Symptom Scale (BNSS) to 179 MDD patients and 152 BD patients. Confirmatory Factor Analysis (CFA) was conducted to examine the one-factor model, the two-factor model of the MAP and the EXP domain, the five-factor model of anhedonia, avolition, asociality, alogia, and blunted affect, and the hierarchical model comprising the first-order five-factor, and the second-order two-factor (MAP and EXP factors). We further examined the correlations between demographics and the negative symptom dimensions found in the best factor model. The CFA showed that, when the CAINS and the BNSS were combined together, the two-factor model of MAP and EXP provided the best model fit than other competing models, in the MDD alone sample, BD alone sample, and the combined clinical sample. The two-factor model of the MAP and EXP appears to be a stable, transdiagnostic latent structure of negative symptoms across BD and MDD. Clarifying negative symptoms in MDD and BD can facilitate future research on the underlying neural mechanisms of the MAP and EXP dimensions.

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精神病消极症状的跨诊断方法:重度抑郁障碍和双相情感障碍双因素结构的复制。
最近的实证研究结果表明,阴性症状并不局限于精神分裂症(SCZ),重度抑郁症(MDD)和双相情感障碍(BD)患者也会出现阴性症状。虽然SCZ患者通常表现出由动机和愉悦(MAP)和表达(EXP)因素组成的潜结构,但MDD和BD患者是否存在同样的潜结构仍不清楚。我们对 179 名 MDD 患者和 152 名 BD 患者进行了阴性症状临床评估访谈(CAINS)和简明阴性症状量表(BNSS)。我们对单因素模型、MAP 和 EXP 领域的双因素模型、失乐症、逃避现实、不合群、厌世和情感淡漠的五因素模型以及由一阶五因素和二阶双因素(MAP 和 EXP 因子)组成的分层模型进行了确证因子分析(CFA)。我们进一步研究了人口统计学特征与最佳因子模型中发现的消极症状维度之间的相关性。CFA显示,当CAINS和BNSS结合在一起时,在MDD单独样本、BD单独样本和综合临床样本中,MAP和EXP的双因子模型比其他竞争模型提供了最佳的模型拟合度。MAP和EXP的双因素模型似乎是BD和MDD负性症状的一个稳定的、跨诊断的潜在结构。厘清 MDD 和 BD 中的消极症状有助于未来对 MAP 和 EXP 维度的潜在神经机制进行研究。
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来源期刊
CiteScore
8.80
自引率
4.30%
发文量
154
审稿时长
6-12 weeks
期刊介绍: The original papers published in the European Archives of Psychiatry and Clinical Neuroscience deal with all aspects of psychiatry and related clinical neuroscience. Clinical psychiatry, psychopathology, epidemiology as well as brain imaging, neuropathological, neurophysiological, neurochemical and moleculargenetic studies of psychiatric disorders are among the topics covered. Thus both the clinician and the neuroscientist are provided with a handy source of information on important scientific developments.
期刊最新文献
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