Inhibitory interferon regulatory factor 5 binding peptide suppresses abdominal aortic aneurysm expansion in vivo.

IF 4.9 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Journal of molecular and cellular cardiology Pub Date : 2024-10-28 DOI:10.1016/j.yjmcc.2024.10.012
Zhen Yuan, Li Shu, Peipei Yang, Jie Sun, Mengsha Zheng, Jiantao Fu, Yidong Wang, Shen Song, Zhenjie Liu, Zhejun Cai
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Abstract

Abdominal aortic aneurysm (AAA) is a critical condition characterized by the expansion of the infrarenal aorta, often leading to high mortality upon rupture. The absence of treatment for asymptomatic AAAs urgently necessitates uncovering the underlying mechanisms of their development. This study utilized mice to induce AAA through porcine pancreatic elastase with BAPN feeding and found that mice receiving the IRF5-binding peptide (IBP) demonstrated significantly slowed AAA expansion and reduced adventitia degradation compared to the control group. Additionally, the IBP group showed decreased macrophage infiltration and reduced matrix metalloproteinase-9 (MMP9) activity. Targeting IRF5 with IBP offers new avenues for potential treatments for asymptomatic AAAs.

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抑制性干扰素调节因子 5 结合肽可抑制腹主动脉瘤在体内的扩张。
腹主动脉瘤(AAA)是一种以肾下主动脉扩张为特征的危重疾病,一旦破裂,死亡率往往很高。由于对无症状的 AAA 缺乏治疗,因此迫切需要揭示其发病机制。本研究利用小鼠通过猪胰腺弹性蛋白酶和 BAPN 喂养诱发 AAA,结果发现,与对照组相比,接受 IRF5 结合肽(IBP)治疗的小鼠明显减缓了 AAA 的扩张,减少了血管内膜的降解。此外,IBP组的巨噬细胞浸润减少,基质金属蛋白酶-9(MMP9)活性降低。用IBP靶向IRF5为无症状AAA的潜在治疗提供了新途径。
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来源期刊
CiteScore
10.70
自引率
0.00%
发文量
171
审稿时长
42 days
期刊介绍: The Journal of Molecular and Cellular Cardiology publishes work advancing knowledge of the mechanisms responsible for both normal and diseased cardiovascular function. To this end papers are published in all relevant areas. These include (but are not limited to): structural biology; genetics; proteomics; morphology; stem cells; molecular biology; metabolism; biophysics; bioengineering; computational modeling and systems analysis; electrophysiology; pharmacology and physiology. Papers are encouraged with both basic and translational approaches. The journal is directed not only to basic scientists but also to clinical cardiologists who wish to follow the rapidly advancing frontiers of basic knowledge of the heart and circulation.
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