Lifestyle empowerment for Alzheimer's prevention prescribed by physicians: Methods and adaptations to COVID-19

IF 2 3区 医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Contemporary clinical trials Pub Date : 2024-11-02 DOI:10.1016/j.cct.2024.107729
Amanda N. Szabo-Reed , Amber Watts , Eric D. Vidoni , Jonathan Mahnken , Angela Van Sciver , Katrina Finley , Jonathan Clutton , Rachel Holden , Mickeal N. Key , Jeffery M. Burns
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Abstract

The health care system is insufficiently capitalizing on the benefits of physical exercise in America's aging population. Few tools exist to help clinicians incorporate physical activity into their clinical care, and barriers limit older adults from initiating and maintaining exercise programs. The Lifestyle Empowerment for Alzheimer's Prevention (LEAP! Rx) Program has been designed to support providers and participants in lifestyle change. LEAP! Rx uses two forms of participant enrollment: physician referrals through electronic health records and self-referrals to test the efficacy of delivering a community-based exercise and healthy lifestyle program to older adults. After referral into the program, participants are randomized to receive the LEAP! Rx Program or are placed in a standard-of-care group to receive the program later. The LEAP! Rx program consists of a personalized and structured exercise program, lifestyle education, and mobile health monitoring. This includes a 12-week Empowerment phase with coaching and supervised exercise training, followed by a 40-week Lifestyle phase with intermittent supervised exercise and coaching. Lifestyle education includes monthly, evidence-based classes on optimal aging. The evaluation of LEAP! Rx focuses on 1) the assessment of implementation and scalability of the LEAP!Rx Program for clinicians and patients 2) the effect of the LEAP! Rx Program on cardiorespiratory fitness, 3) the impact of the LEAP! Rx Program on secondary intervention outcome measures of chronic disease risk factors, including insulin resistance, body composition, and lipids. If successful, this study's findings could advance future healthcare practices, providing a new and practical approach to aging and chronic disease prevention.
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医生处方的阿尔茨海默氏症预防生活方式赋权:COVID-19 的方法和调整。
医疗保健系统没有充分利用体育锻炼对美国老龄人口的益处。很少有工具可以帮助临床医生将体育锻炼纳入其临床护理中,而各种障碍也限制了老年人启动和维持锻炼计划。阿尔茨海默氏症预防生活方式赋权(LEAP!LEAP!Rx 采用两种形式招募参与者:医生通过电子健康记录转介和自我转介,以测试向老年人提供基于社区的运动和健康生活方式计划的效果。在被转介到该计划后,参与者将随机接受 LEAP!Rx 计划,或被安排在标准护理组,稍后再接受该计划。LEAP!Rx 计划包括个性化的结构化锻炼计划、生活方式教育和移动健康监测。其中包括为期 12 周的赋能阶段,包括指导和有监督的运动训练,随后是为期 40 周的生活方式阶段,包括间歇性的有监督的运动和指导。生活方式教育包括每月一次的最佳老龄化循证课程。LEAP!Rx 计划的评估重点是:1)评估临床医生和患者对 LEAP!Rx 计划对心肺功能的影响,3)LEAP!Rx计划对慢性病风险因素(包括胰岛素抵抗、身体成分和血脂)的二级干预结果测量的影响。如果研究成功,这项研究的结果将推动未来医疗保健实践的发展,为老龄化和慢性疾病预防提供一种新的实用方法。
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来源期刊
CiteScore
3.70
自引率
4.50%
发文量
281
审稿时长
44 days
期刊介绍: Contemporary Clinical Trials is an international peer reviewed journal that publishes manuscripts pertaining to all aspects of clinical trials, including, but not limited to, design, conduct, analysis, regulation and ethics. Manuscripts submitted should appeal to a readership drawn from disciplines including medicine, biostatistics, epidemiology, computer science, management science, behavioural science, pharmaceutical science, and bioethics. Full-length papers and short communications not exceeding 1,500 words, as well as systemic reviews of clinical trials and methodologies will be published. Perspectives/commentaries on current issues and the impact of clinical trials on the practice of medicine and health policy are also welcome.
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