Impact of Transoral Robotic Surgery Versus Radiation on Swallowing Function in Oropharyngeal Cancer Patients: A Sub-Study From a Randomized Trial.

IF 2.3 3区医学 Q1 OTORHINOLARYNGOLOGY Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2024-11-04 DOI:10.1002/hed.27986

Julie A Theurer, Rosemary Martino, Nedeljko Jovanovic, John R de Almeida, David P Goldstein, Kevin Fung, John Yoo, S Danielle MacNeil, Eric Winquist, J Alex Hammond, Varagur Venkatesan, Nancy Read, Sarah Kuruvilla, Andrew Warner, Philip C Doyle, Ian Ross, Colleen Dreyer, Sarah Hawkins, Kendra Thouless, Courtney McCallum, David A Palma, Anthony C Nichols

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Abstract

Background: This ORATOR sub-study evaluated swallowing physiology in patients treated with transoral robotic surgery (TORS) versus radiotherapy (RT) for early-stage oropharynx cancer.

Methods: Swallowing physiology was evaluated using videofluoroscopy and outcomes were compared across treatment arms and correlated with MDADI scores.

Results: Of the 68 patients in the ORATOR trial, 21 participated in this sub-study (30.8%), including 15 RT Arm and six TORS Arm patients. Swallowing profiles were not significantly different between the arms. MBSImP pharyngeal scores for RT Arm versus TORS Arm patients were 4.8 (±2.1) versus 4.3 (±1.5) at baseline, 6.2 (±1.2) versus 9.6 (±4.8) at 6 months and 5.9 (±1.8) versus 8.0 (±4.7) at 12 months. MBSImP pharyngeal scores demonstrated weak associations with several MDADI subscales and PAS scores.

Conclusions: To best describe swallowing outcomes in studies of RT and/or surgery, instrumental swallowing assessments should be strongly considered in addition to quality of life measures.

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经口机器人手术与放射治疗对口咽癌患者吞咽功能的影响：一项随机试验的子研究。

背景：这项 ORATOR 子研究评估了经口机器人手术（TORS）与放疗（RT）治疗早期口咽癌患者的吞咽生理学：这项ORATOR子研究评估了早期口咽癌经口机器人手术（TORS）与放疗（RT）治疗患者的吞咽生理学：方法：使用视频荧光镜评估吞咽生理学，比较各治疗组的结果，并与MDADI评分相关联：在ORATOR试验的68名患者中，有21名患者（30.8%）参加了本次子研究，其中包括15名RT治疗臂患者和6名TORS治疗臂患者。两组患者的吞咽情况无明显差异。RT 治疗组和 TORS 治疗组患者的咽部 MBSImP 评分基线分别为 4.8（±2.1）分和 4.3（±1.5）分，6 个月时分别为 6.2（±1.2）分和 9.6（±4.8）分，12 个月时分别为 5.9（±1.8）分和 8.0（±4.7）分。MBSImP咽部评分与几个MDADI分量表和PAS评分的关联性较弱：为了在 RT 和/或手术研究中最好地描述吞咽结果，除了生活质量测量之外，还应该着重考虑工具性吞咽评估。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck 医学-耳鼻喉科学

CiteScore

7.00

自引率

6.90%

发文量

278

审稿时长

1.6 months

期刊介绍： Head & Neck is an international multidisciplinary publication of original contributions concerning the diagnosis and management of diseases of the head and neck. This area involves the overlapping interests and expertise of several surgical and medical specialties, including general surgery, neurosurgery, otolaryngology, plastic surgery, oral surgery, dermatology, ophthalmology, pathology, radiotherapy, medical oncology, and the corresponding basic sciences.