David Wang, Cody Thornburgh, Harjeet Singh, Zach Holliday
{"title":"Cystic fibrosis or asthma? Discerning dyspnea with hyperpolarizaed xenon gas magnetic resonance imaging.","authors":"David Wang, Cody Thornburgh, Harjeet Singh, Zach Holliday","doi":"10.1016/j.mri.2024.110271","DOIUrl":null,"url":null,"abstract":"<p><p>Hyperpolarized Xenon MRI (HPG MRI) has been studied for its potential use in assessing lung function in patients with cystic fibrosis (CF) and in patients with asthma. We present a case of a man with overlapping cystic fibrosis and allergic asthma with severe obstructive lung disease in which spirometry and computed topography (CT) imaging was unable to determine the primary cause for his uncontrolled symptoms. HPG MRI was used to guide a tissue biopsy and determine the primary driver to be allergic asthma. After starting targeted therapy for severe asthma, his symptoms have greatly improved.</p>","PeriodicalId":18165,"journal":{"name":"Magnetic resonance imaging","volume":null,"pages":null},"PeriodicalIF":2.1000,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Magnetic resonance imaging","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.mri.2024.110271","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
引用次数: 0
Abstract
Hyperpolarized Xenon MRI (HPG MRI) has been studied for its potential use in assessing lung function in patients with cystic fibrosis (CF) and in patients with asthma. We present a case of a man with overlapping cystic fibrosis and allergic asthma with severe obstructive lung disease in which spirometry and computed topography (CT) imaging was unable to determine the primary cause for his uncontrolled symptoms. HPG MRI was used to guide a tissue biopsy and determine the primary driver to be allergic asthma. After starting targeted therapy for severe asthma, his symptoms have greatly improved.
期刊介绍:
Magnetic Resonance Imaging (MRI) is the first international multidisciplinary journal encompassing physical, life, and clinical science investigations as they relate to the development and use of magnetic resonance imaging. MRI is dedicated to both basic research, technological innovation and applications, providing a single forum for communication among radiologists, physicists, chemists, biochemists, biologists, engineers, internists, pathologists, physiologists, computer scientists, and mathematicians.