Magnetic resonance imaging最新文献

Large gains in SNR through the application of Shinnar-Le Roux RF pulse design to short-TR spin-echo fMRI acquisitions at 7 T 通过将Shinnar-Le Roux射频脉冲设计应用于7 T的短tr自旋回波fMRI采集，可大幅提高信噪比。

IF 2 4区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Magnetic resonance imaging

Pub Date : 2026-02-06 DOI: 10.1016/j.mri.2026.110639

Mukund Balasubramanian , Robert V. Mulkern , William A. Grissom , Jonathan R. Polimeni

Purpose

The optimal excitation flip angle (FA) for short-TR spin-echo acquisitions can be well above 90°, far beyond the small FAs suited for commonly-used sinc RF pulses. The goal of this study was to characterize the benefits of Shinnar-Le Roux (SLR) over sinc pulses for these acquisitions, which may lead to improvements in the temporal and spatial specificity of fMRI.

Methods

Slice profiles were obtained either through Bloch simulation or from scans of an oil phantom at 7 T (T₁/TR = 1500/300 ms). Spatial integrals of the slice profiles were used as measures of the resulting (relative) SNR. We also measured the spatial profile of spin-echo “linescan” acquisitions, which are of increasing interest for in vivo studies of cortical layers.

Results

For 2D acquisitions with the parameter values used here, the high-quality slice profiles provided by the SLR pulses resulted in an SNR gain of ∼100% relative to sinc pulses. For 1D linescan acquisitions, the SNR gains were even higher: ∼150%.

Conclusions

The large gains in SNR described here should enhance any studies using short-TR spin-echo acquisitions; in particular, we anticipate application of these SLR pulses to fMRI studies that target the microvasculature with both high spatial and high temporal resolution. Potential limitations, due to high SAR or B₁⁺ inhomogeneity, should however be kept in mind, especially at ultra-high field strengths.

目的：用于短tr自旋回波采集的最佳激励翻转角（FA）可以远远超过90°，远远超过适用于常用的自旋射频脉冲的小FA。本研究的目的是表征sinnar - le Roux （SLR）相对于正弦脉冲的优势，这可能导致fMRI的时间和空间特异性的改善。方法：通过Bloch模拟或在7 T （T1/TR = 1500/300 ms）扫描油幻影获得切片剖面。切片剖面的空间积分被用作测量结果（相对）信噪比。我们还测量了自旋回波“线扫描”获取的空间剖面，这对皮层的体内研究越来越感兴趣。结果：对于使用本文参数值的二维采集，单反脉冲提供的高质量切片剖面相对于正弦脉冲产生了约100%的信噪比增益。对于一维线性扫描采集，信噪比增益甚至更高：约150%。结论：本文描述的信噪比的大幅提高应该加强任何使用短tr自旋回波采集的研究；特别是，我们期望将这些单反脉冲应用于以高空间和高时间分辨率为目标的微血管功能磁共振成像研究。然而，由于高SAR或B1+不均匀性，应牢记潜在的局限性，特别是在超高场强下。

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引用次数: 0

Pediatric coronary MR angiography with a two-minute scan using de-aliasing regularization based compressed sensing. 小儿冠状动脉磁共振血管造影与两分钟扫描使用去混叠正则化基于压缩感知。

IF 2 4区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Magnetic resonance imaging

Pub Date : 2026-02-02 DOI: 10.1016/j.mri.2026.110627

Zhihao Xue, Guanke Cai, Xuanhong Liu, Yan Zheng, Junpu Hu, Xihong Hu, Chenxi Hu

Background: Long acquisition time limits the clinical utility of coronary magnetic resonance angiography (CMRA) in pediatric populations. While deep learning-based reconstruction methods such as De-Aliasing Regularization-based Compressed Sensing (DARCS) hold promise for accelerating CMRA, its clinical feasibility in pediatric populations remains unexplored.

Purpose: This study aims to reduce scan time and evaluate the image quality and diagnostic performance of DARCS-accelerated CMRA in pediatric coronary imaging, with a focus on coronary artery aneurysms (CAAs) detection.

Study design: A two-phase study including retrospective technique development and prospective clinical validation was performed.

Methods: CMRA was performed using a 3.0 T scanner with a three-dimensional diaphragm-navigated, T2 prepared gradient echo sequence. In the Phase I, pediatric CMRA k-space data were retrospectively undersampled to train and test DARCS reconstruction, with comparison to SENSE, patch-based reconstruction (PROST), and hybrid deep-learning iterative reconstruction (hybrid DL-IR). In Phase II, patients prospectively underwent both conventional 3× accelerated CMRA and 8× DARCS-CMRA. Images were assessed using quantitative image metrics (peak signal-to-noise ratio (PSNR), structural similarity index measure (SSIM)), coronary artery assessments (vessel lengths, sharpness, and visual scores). Diagnostic performance for CAA detection was evaluated at both patient and vessel levels.

Results: A total of 123 pediatric patients were included for final analysis, including 96 for the retrospective phase and 27 for the prospective phase. DARCS outperformed the second highest-performance reconstruction method in PSNR (31.74 ± 2.17 vs. 30.69 ± 2.12, P < 0.001 at 8× acceleration), improved vessel length (LAD: 75.86 ± 20.17 mm vs. 72.23 ± 20.80 mm, P < 0.001; RCA: 84.94 ± 20.36 mm vs. 80.12 ± 20.54 mm, P < 0.001), and improved subjective scoring (LAD: 3.22 ± 0.83 vs. 3.11 ± 0.89, P = 0.102 > 0.05; RCA: 3.53 ± 0.81 vs. 3.42 ± 0.81, P = 0.046 < 0.05). In the prospective phase, DARCS-CMRA achieved a 100% sensitivity and specificity in detection of CAA at both patient and vessel levels, with conventional CMRA as the reference, despite a significantly shorter scan time (92.4 ± 19.1 s vs. 208.8 ± 52.0 s).

Conclusion: DARCS offers improved reconstruction quality for accelerated CMRA compared to conventional methods, enabling preservation of CAA diagnostic accuracy despite a two-minute scan.

背景：采集时间长限制了冠状动脉磁共振血管造影（CMRA）在儿科人群中的临床应用。虽然基于深度学习的重建方法，如去混叠正则化压缩感知（DARCS）有望加速CMRA，但其在儿科人群中的临床可行性仍未得到探索。目的：本研究旨在缩短扫描时间，评估darcs加速CMRA在儿童冠状动脉成像中的图像质量和诊断性能，重点研究冠状动脉瘤（CAAs）的检测。研究设计：本研究分为两阶段，包括回顾性技术开发和前瞻性临床验证。方法：CMRA采用3.0 T扫描仪，三维横膈膜导航，T2制备梯度回波序列。在第一阶段，对儿童CMRA k空间数据进行回顾性欠采样，以训练和测试DARCS重建，并与SENSE、基于补丁的重建（PROST）和混合深度学习迭代重建（hybrid DL-IR）进行比较。在II期，患者预期接受了常规的3×加速CMRA和8× DARCS-CMRA。使用定量图像指标（峰值信噪比（PSNR）、结构相似性指数（SSIM））、冠状动脉评估（血管长度、清晰度和视觉评分）对图像进行评估。在患者和血管水平上评估CAA检测的诊断性能。结果：共有123例儿童患者纳入最终分析，其中回顾性研究96例，前瞻性研究27例。DARCS优于第二个重建方法PSNR性能最高(31.74 ± 2.17 vs 30.69 ± 2.12,P  0.05;RCA: 3.53 ± 0.81 vs 3.42 ± 0.81,P = 0.046  结论:DARCS为加速CMRA提供提高重建质量与传统的方法相比,使保护创新艺人经纪公司诊断准确性尽管两分钟扫描。

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引用次数: 0

Tissue-specific nuclear spin-spin relaxation anisotropy and water nano-confinement in celery stalks. 芹菜茎中组织特异性核自旋-自旋弛豫各向异性和水纳米约束。

IF 2 4区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Magnetic resonance imaging

Pub Date : 2026-02-02 DOI: 10.1016/j.mri.2026.110638

Alexander Panich, Ilana Bar

Recent magnetic resonance imaging (MRI) measurements have revealed proton spin-spin relaxation anisotropy in only one component of the celery stalk, even though water accounts for up to 95% of its weight and is present throughout all its tissues. Our analysis shows that this anisotropy arises from nanoconfined water within the collenchyma cell walls. In these regions, restricted molecular motion and hydrogen bonding between water molecules and cell-wall constituents give rise to residual anisotropic dipolar interactions. In contrast, water in the xylem, phloem, and parenchyma occupies larger cavities, acts like a bulk liquid, and shows no angular dependence in its nuclear relaxation behavior. These results suggest that nuclear spin-spin relaxation anisotropy may serve as a unique feature of nanoconfined water in biological tissues, contributing to the study of water behavior in plants, their microscopic structures, and aiding research on plant physiology.

最近的磁共振成像（MRI）测量显示，尽管水占芹菜茎重量的95%，并且存在于芹菜的所有组织中，但只有芹菜茎的一种成分存在质子自旋-自旋弛豫各向异性。我们的分析表明，这种各向异性是由厚壁细胞壁内的纳米水引起的。在这些区域，受限制的分子运动和水分子与细胞壁组分之间的氢键产生了残余的各向异性偶极相互作用。相比之下，木质部、韧皮部和薄壁组织中的水占据较大的空腔，像散装液体一样，其核弛豫行为没有角依赖性。这些结果表明，核自旋-自旋弛豫各向异性可能是生物组织中纳米密闭水的独特特征，有助于研究植物的水行为及其微观结构，并有助于植物生理学的研究。

引用次数: 0

DeepVBM: A fully automatic and efficient voxel-based morphometry via deep learning-based segmentation and registration methods. DeepVBM：通过基于深度学习的分割和配准方法，实现全自动、高效的基于体素的形态测量。

IF 2 4区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Magnetic resonance imaging

Pub Date : 2026-02-02 DOI: 10.1016/j.mri.2026.110637

Pei-Mao Sun, Teng-Yi Huang, Tzu-Chao Chuang, Yi-Ru Lin, Hsiao-Wen Chung

Voxel-based morphometry (VBM) using T1-weighted magnetic resonance imaging is a pivotal tool for assessing brain structure and identifying subtle morphological changes associated with various neurological conditions. Conventional VBM workflows, however, face significant computational challenges, particularly during the nonlinear deformable registration stage, which impedes analysis of large-scale neuroimaging databases. In this study, we introduce FuseMorph, a deep learning-based registration method that refines initial zero-shot predictions from a pretrained model via iterative inference and targeted parameter search. By eliminating the need for full backpropagation and additional model retraining, FuseMorph significantly reduces computational demands, achieving registration accuracy comparable to state-of-the-art methods even in CPU-only environments. FuseMorph is integrated into DeepVBM, a fully automated VBM pipeline streamlines the processing of high-resolution MRI datasets and substantially reduces computation time compared to traditional pipelines, thereby facilitating the efficient analysis of large multi-center studies. The proposed approach was validated on multiple datasets, including an Alzheimer's disease cohort where DeepVBM successfully detected characteristic patterns of gray matter atrophy in regions such as the hippocampus, entorhinal cortex, and amygdala. These findings not only underscore the clinical relevance of the method but also demonstrate its potential for early detection and monitoring of neurodegenerative changes. This work contributes an accessible, efficient, and scalable solution for neuroimaging research, with potential applications extending to various neurodegenerative disease studies.

基于体素的形态测量（VBM）使用t1加权磁共振成像是评估大脑结构和识别与各种神经系统疾病相关的细微形态变化的关键工具。然而，传统的VBM工作流程面临着重大的计算挑战，特别是在非线性可变形配准阶段，这阻碍了大规模神经成像数据库的分析。在本研究中，我们引入了FuseMorph，这是一种基于深度学习的配准方法，通过迭代推理和目标参数搜索，从预训练模型中细化初始零射击预测。通过消除完全反向传播和额外的模型再训练的需要，FuseMorph显着降低了计算需求，即使在只有cpu的环境中，也能实现与最先进方法相当的配准精度。FuseMorph集成到DeepVBM中，一个全自动的VBM管道简化了高分辨率MRI数据集的处理，与传统管道相比，大大减少了计算时间，从而促进了大型多中心研究的高效分析。该方法在多个数据集上得到验证，包括一个阿尔茨海默病队列，其中DeepVBM成功检测到海马、内嗅皮层和杏仁核等区域灰质萎缩的特征模式。这些发现不仅强调了该方法的临床相关性，而且还证明了其在神经退行性变化的早期检测和监测方面的潜力。这项工作为神经影像学研究提供了一种方便、高效、可扩展的解决方案，并有可能应用于各种神经退行性疾病的研究。

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引用次数: 0

Evaluation of the diagnostic value of DCE-MRI radiomics features and K-trans parameters in differentiating endometrial cancer from submucosal uterine fibroids. DCE-MRI放射组学特征及K-trans参数对子宫内膜癌与粘膜下子宫肌瘤鉴别诊断价值的评价

IF 2 4区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Magnetic resonance imaging

Pub Date : 2026-01-23 DOI: 10.1016/j.mri.2026.110625

LiJian Su, KeWu Wang, ShengXiang Xiao, LiuYan Xu, JiBo Hu

Objective: To explore the diagnostic value of Dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) radiomics features and qualitative parameters for the differential diagnosis of endometrial cancer (EC) and submucosal uterine fibroidsuterine fibroids.

Methods: This retrospective study included 70 cases of endometrial cancer patients collected from our hospital between October 2022 and October 2024, assigned to the EC group, and another 35 cases of uterine leiomyoma patients during the same period were collected as the benign group according to the 2:1 matching principle. Baseline data, DCE-MRI parameters [rate constant (Kep), volume transport constant (Ktrans), and volume fraction of extracellular space (Ve)] and radiomics characteristics were compared between the two groups. The influencing factors of DCE-MRI parameters and radiomics features on EC were analyzed, as well as their diagnostic value in differentiation, and external validation of the diagnostic value in differentiation was conducted.

Results: Ktrans and Kep in EC group were higher than those in benign group, while Ve was lower (P < 0.05). The radiomic score of the EC group was higher than that of the benign group (P < 0.05). Logistic regression analysis found that Ktrans, Kep, Ve, and radiomic score were factors affecting EC (P < 0.05). The AUC values for the DCE-MRI model, radiomics model, and combined model in predicting the differential diagnosis of EC were 0.695, 0.775, and 0.867, respectively. Among them, the combined model demonstrated the highest predictive value, significantly surpassing that of the DCE-MRI and radiomics models (P < 0.05). The decision curve indicated that the clinical positive benefit achieved by the combined model in differential diagnosis of EC surpassed that of the DCE-MRI and radiomics models (P < 0.05). The calibration curve showed that the calibration curve for differential diagnosis of EC fitted well with the ideal curve. The external validation results demonstrated that the combined diagnostic model exhibited good predictive value.

Conclusion: The combination of DCE-MRI parameters and radiomics features can be used for the differential diagnosis of EC, demonstrating good predictive efficacy and clinical applicability, providing a reliable imaging diagnostic method for clinical diagnosis of EC.

目的：探讨动态对比增强磁共振成像（DCE-MRI）放射组学特征及定性参数对子宫内膜癌（EC）和粘膜下子宫肌瘤鉴别诊断的价值。方法：回顾性研究选取我院于2022年10月至2024年10月收治的70例子宫内膜癌患者作为EC组，同时按照2:1匹配原则选取同期收治的35例子宫平滑肌瘤患者作为良性组。比较两组的基线数据、DCE-MRI参数[速率常数（Kep）、体积运输常数（Ktrans）和细胞外空间体积分数（Ve）]和放射组学特征。分析DCE-MRI参数及放射组学特征对EC的影响因素及其鉴别诊断价值，并对其鉴别诊断价值进行外部验证。结果：EC组Ktrans、Kep高于良性组，Ve低于良性组（P ）结论：DCE-MRI参数与放射组学特征相结合可用于EC的鉴别诊断，具有良好的预测效果和临床适用性，为EC的临床诊断提供了可靠的影像学诊断方法。

{"title":"Evaluation of the diagnostic value of DCE-MRI radiomics features and K-trans parameters in differentiating endometrial cancer from submucosal uterine fibroids.","authors":"LiJian Su, KeWu Wang, ShengXiang Xiao, LiuYan Xu, JiBo Hu","doi":"10.1016/j.mri.2026.110625","DOIUrl":"10.1016/j.mri.2026.110625","url":null,"abstract":"<p><strong>Objective: </strong>To explore the diagnostic value of Dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) radiomics features and qualitative parameters for the differential diagnosis of endometrial cancer (EC) and submucosal uterine fibroidsuterine fibroids.</p><p><strong>Methods: </strong>This retrospective study included 70 cases of endometrial cancer patients collected from our hospital between October 2022 and October 2024, assigned to the EC group, and another 35 cases of uterine leiomyoma patients during the same period were collected as the benign group according to the 2:1 matching principle. Baseline data, DCE-MRI parameters [rate constant (Kep), volume transport constant (Ktrans), and volume fraction of extracellular space (Ve)] and radiomics characteristics were compared between the two groups. The influencing factors of DCE-MRI parameters and radiomics features on EC were analyzed, as well as their diagnostic value in differentiation, and external validation of the diagnostic value in differentiation was conducted.</p><p><strong>Results: </strong>Ktrans and Kep in EC group were higher than those in benign group, while Ve was lower (P < 0.05). The radiomic score of the EC group was higher than that of the benign group (P < 0.05). Logistic regression analysis found that Ktrans, Kep, Ve, and radiomic score were factors affecting EC (P < 0.05). The AUC values for the DCE-MRI model, radiomics model, and combined model in predicting the differential diagnosis of EC were 0.695, 0.775, and 0.867, respectively. Among them, the combined model demonstrated the highest predictive value, significantly surpassing that of the DCE-MRI and radiomics models (P < 0.05). The decision curve indicated that the clinical positive benefit achieved by the combined model in differential diagnosis of EC surpassed that of the DCE-MRI and radiomics models (P < 0.05). The calibration curve showed that the calibration curve for differential diagnosis of EC fitted well with the ideal curve. The external validation results demonstrated that the combined diagnostic model exhibited good predictive value.</p><p><strong>Conclusion: </strong>The combination of DCE-MRI parameters and radiomics features can be used for the differential diagnosis of EC, demonstrating good predictive efficacy and clinical applicability, providing a reliable imaging diagnostic method for clinical diagnosis of EC.</p>","PeriodicalId":18165,"journal":{"name":"Magnetic resonance imaging","volume":" ","pages":"110625"},"PeriodicalIF":2.0,"publicationDate":"2026-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146046898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In Memoriam: Dr. Shoji Naruse (1945-2025). 纪念：成濑正二博士（1945-2025）。

IF 2 4区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Magnetic resonance imaging

Pub Date : 2026-01-23 DOI: 10.1016/j.mri.2026.110626

Ichio Aoki, Chuzo Tanaka, Toshihiro Higuchi, Toshihiko Ebisu, Masahiro Umeda, Masaki Fukunaga, Yuki Mori, Yoshiharu Horikawa, Seiichi Furuya, Takaaki Tokumitsu, Tetsuro Takegami, Kei Yamada

引用次数: 0

Paramagnetic susceptibility versus QSM for estimating OEF: A comparative study in cerebral small vessel disease 顺磁化率与QSM评估OEF：脑血管疾病的比较研究。

IF 2 4区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Magnetic resonance imaging

Pub Date : 2026-01-21 DOI: 10.1016/j.mri.2026.110623

Wenyu Zhou , Dan Luo , Hao Chen , Meiling Wang , Yongmei Li

Background

The oxygen extraction fraction (OEF) is a key parameter of cerebral metabolism and a potential biomarker for cerebral small vessel disease (SVD). Quantitative susceptibility mapping (QSM) allows non-invasive OEF mapping but is confounded by the opposing magnetic susceptibilities of deoxyhemoglobin and oxyhemoglobin. We evaluated a novel method that separates the paramagnetic susceptibility component for OEF estimation and compared it with conventional QSM in SVD patients and healthy controls (HC).

Methods

27 SVD patients and 23 HC underwent multi-echo GRE MRI for QSM reconstruction. The paramagnetic susceptibility was separated using APART-QSM. The straight sinus (SS) and superior sagittal sinus (SSS) were segmented for regional OEF calculation using both conventional QSM and paramagnetic susceptibility. Statistical comparisons were performed using Welch's t-test.

Results

Paramagnetic susceptibility was significantly higher than total QSM (p < 0.05), while OEF derived from paramagnetic susceptibility was significantly lower (p < 0.05). OEF values derived from paramagnetic susceptibility (HC: 22.5 ± 4.8% in SS, 19.3 ± 4.6% in SSS; SVD: 23.4 ± 5.1% in SS, 19.0 ± 4.5% in SSS) were significantly lower (p < 0.05) than those obtained via conventional QSM (HC: 29.0 ± 3.5% in SS, 26.8 ± 3.3% in SSS; SVD: 29.8 ± 3.8% in SS, 26.5 ± 3.2% in SSS). No significant OEF differences were found between HC and SVD cohorts in the analyzed venous regions.

Conclusion

This study demonstrates the feasibility of separating the paramagnetic susceptibility component via APART-QSM for quantitative OEF estimation. While the derived OEF values were lower than those from conventional QSM, the method theoretically offers improved specificity by disentangling deoxygenation-driven susceptibility from diamagnetic confounds, highlighting its potential as a refined biomarker for cerebral oxygen metabolism subject to further optimization.

背景：氧提取分数（OEF）是脑代谢的关键参数，也是脑小血管疾病（SVD）的潜在生物标志物。定量敏感性制图（QSM）允许非侵入性OEF制图，但被脱氧血红蛋白和氧合血红蛋白的相反磁化率所混淆。我们评估了一种分离顺磁化率分量用于OEF估计的新方法，并将其与SVD患者和健康对照（HC）的传统QSM进行了比较。方法：27例SVD患者和23例HC患者行多回波GRE MRI QSM重建。采用APART-QSM分离顺磁化率。采用常规QSM和顺磁化率对直窦（SS）和上矢状窦（SSS）进行分割，计算局部OEF。采用Welch’st检验进行统计学比较。结果：顺磁化率显著高于总QSM （p ）。结论：本研究证明了利用APART-QSM分离顺磁化率分量定量估计OEF的可行性。虽然得到的OEF值低于传统QSM，但理论上该方法通过将脱氧驱动的敏感性从反磁混淆中分离出来，提高了特异性，突出了其作为脑氧代谢精细生物标志物的潜力，有待进一步优化。

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引用次数: 0

Efficient B1+ modeling for fast quantification of PDFF and two-compartment T1, T2* relaxation times in abdominal MRI of steatotic patients at 1.5 T 高效B1+模型快速量化脂肪变性患者1.5 T时腹部MRI PDFF和双室T1、T2*松弛时间。

IF 2 4区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Magnetic resonance imaging

Pub Date : 2026-01-20 DOI: 10.1016/j.mri.2026.110622

Kouame Ferdinand Kouakou , Anita Paisant , Laurent Arnould , Christophe Aube , Hervé Saint-Jalmes

Purpose

To propose and preliminarily evaluate a rapid method with potential clinical applicability for correcting the B1+ spatial variation in quantitative abdominal MRI.

Materials and methods

The 3D VFA method allows rapid quantification of the T1 relaxation time and is particularly suitable for abdominal imaging, but requires mapping of the B1+ field throughout the 3D volume, which is often not available on clinical MRI scanners. The proposed method, called B1MM, combines a rapid 2D mapping of the B1+ field with modelling of the excitation coil properties to generate a B1+ mapping over a large 3D volume. The method was first validated on phantoms and a healthy volunteer against reference T1-mapping techniques. The method was then applied to simultaneously estimate PDFF, T1, and T2* in the liver, abdominal muscles, and fat of six patients with steatosis using a VFA-based two-compartment model. The six patients were scanned on a 1.5 T clinical MRI (Magnetom Sola, Siemens Healthineers, Erlangen) with a total protocol duration of 25 s. A comparison of the results with and without angle correction and with the literature was performed.

Results

In both phantoms and the volunteer, angle correction brought T1 values close to the reference. In the six patients, as expected, angle correction had no effect on PDFF or T2*, but it markedly reduced T1 variability and improved T1 measurement accuracy. In addition, the total acquisition time is considerably reduced, which improves patient comfort.

目的：提出并初步评价一种具有临床应用潜力的腹部定量MRI B1+空间变异快速校正方法。材料和方法：3D VFA方法可以快速量化T1松弛时间，特别适用于腹部成像，但需要在整个3D体积中绘制B1+场，这在临床MRI扫描仪上通常是不可用的。所提出的方法称为B1MM，将B1+场的快速2D映射与励磁线圈特性建模相结合，在一个大的3D体积上生成B1+映射。该方法首先在幽灵和健康志愿者身上进行验证，对照参考t1映射技术。然后使用基于vfa的双室模型，将该方法应用于同时估计6例脂肪变性患者肝脏、腹肌和脂肪中的PDFF、T1和T2*。6例患者在1.5 T临床MRI （Magnetom Sola, Siemens Healthineers, Erlangen）上进行扫描，总方案持续时间为25 s。并与文献进行了角度校正和不进行角度校正的结果比较。结果：在幻影和志愿者中，角度校正使T1值接近参考值。在6例患者中，正如预期的那样，角度校正对PDFF和T2*没有影响，但明显降低了T1变异性，提高了T1测量精度。此外，总的获取时间大大减少，这提高了患者的舒适度。

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引用次数: 0

Susceptibility-weighted imaging findings in a patient with systemic cobalt toxicity 系统性钴中毒患者的敏感性加权成像结果。

IF 2 4区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Magnetic resonance imaging

Pub Date : 2026-01-20 DOI: 10.1016/j.mri.2026.110624

Rahul Monga , Earn Chun Christabel Lee , Kelly Johnson-Arbor

Introduction

Systemic manifestations of cobalt toxicity include neurological, cardiac, and endocrine dysfunction. Neuroimaging findings in patients with cobalt intoxication are not well characterized.

Case summary

A 45-year-old woman developed bilateral sensorineural hearing loss after undergoing revision total hip arthroplasty and was subsequently diagnosed with cobalt toxicity. She underwent a second revision total hip arthroplasty, but her hearing loss persisted. As part of her otolaryngology evaluation, magnetic resonance imaging of the internal auditory canals was performed. Susceptibility-weighted imaging sequences on magnetic resonance imaging revealed increased mineralization in the basal ganglia and midbrain.

Discussion

Susceptibility-weighted imaging, which uses magnetic properties of tissues to enhance imaging, can detect mineral deposition in the brain. Since cobalt is magnetic, its brain deposition may be identified on susceptibility-weighted imaging, but the clinical implications of this are unclear.

Conclusion

Magnetic resonance imaging abnormalities, including mineralization on susceptibility-weighted imaging sequences, may occur in patients with systemic cobalt toxicity. Further research efforts may clarify the clinical significance of these abnormalities in cobalt-poisoned individuals.

简介：钴中毒的全身表现包括神经、心脏和内分泌功能紊乱。钴中毒患者的神经影像学表现尚不明确。病例总结：一名45岁女性在接受翻修全髋关节置换术后出现双侧感音神经性听力损失，随后被诊断为钴毒性。她接受了第二次翻修全髋关节置换术，但她的听力损失仍然存在。作为耳鼻喉科评估的一部分，进行了内耳道磁共振成像。磁共振敏感性加权成像序列显示基底神经节和中脑矿化增加。讨论：敏感性加权成像，利用组织的磁性来增强成像，可以检测大脑中的矿物质沉积。由于钴是磁性的，它的脑沉积可以通过敏感性加权成像来识别，但临床意义尚不清楚。结论：磁共振成像异常，包括矿化的敏感性加权成像序列，可能发生在全身性钴中毒患者。进一步的研究可能阐明这些异常在钴中毒个体中的临床意义。

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引用次数: 0

Decreased levels of N-Acetylaspartyglutamate, myo-inositol, and syllo-inositol, in cortical brain regions of women exposed to adverse childhood experiences 暴露于不良童年经历的女性大脑皮层区域n -乙酰天冬氨酸、肌醇和基肌醇水平降低。

IF 2 4区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Magnetic resonance imaging

Pub Date : 2026-01-20 DOI: 10.1016/j.mri.2026.110621

Rocío Artigas , Sergio Ruiz , Cristián Montalba , Claudio Peñafiel , Rodrigo Figueroa , Pablo Irarrazaval

Adverse Childhood Experiences (ACE), including abuse and neglect, can have lasting negative effects on health, decreasing lifespan and increasing the risk of chronic diseases. While research on ACE's impact on brain biochemistry is limited, Magnetic Resonance Spectroscopy (MRS) provides a non-invasive way to study these alterations. This study aims to identify neurochemical patterns linked to ACE exposure using J-edited MRS methods.

43 female participants (18 Low-ACE and 25 High-ACE), aged 19 to 31, were recruited. ACE exposure was assessed using the Maltreatment and Abuse Chronology of Exposure (MACE) test. MRS was conducted on a 3.0 T scanner, with J-edited single-voxel 1H-MRS from the Anterior Cingulate Cortex (ACC), Pre-Frontal Cortex (PFC), and hippocampus. Metabolite quantification was carried out using the Osprey pipeline and analyzed using univariate and multivariate methods.

Univariate analysis showed reduced N-Acetylaspartyglutamate (NAAG) and syllo-Inositol (sI) levels in the ACC (p = 0.06) and PFC (p = 0.057), respectively, among High-ACE participants. Logistic Regression identified lower NAAG, GABA, glutathione (GSH), and myo-Inositol (mI) in the ACC, and differences in sI, lactate, NAAG, and GSH in the PFC, within the High-ACE group. Random Forest and Support Vector Machines confirmed NAAG, mI, and sI as possible ACE biomarkers.

Throughout this study, cortical regions consistently showed reduced levels of NAAG, mI, and sI in the High-ACE group, suggesting a potential link to ACE. These findings improve our understanding of neurochemical changes associated with ACE, aiding in the identification of at-risk individuals and in the development of strategies to prevent long-term health effects.

不良童年经历，包括虐待和忽视，可对健康产生持久的负面影响，缩短寿命并增加患慢性病的风险。虽然ACE对脑生化影响的研究有限，但磁共振波谱（MRS）提供了一种非侵入性的方法来研究这些改变。本研究旨在使用j编辑的MRS方法确定与ACE暴露相关的神经化学模式。招募了43名女性参与者（18名低ace和25名高ace），年龄19至31岁。使用虐待和虐待暴露年表（MACE）测试评估ACE暴露。在3.0 T扫描仪上进行MRS，使用来自前扣带皮层（ACC）、前额叶皮层（PFC）和海马的j编辑的单体素1H-MRS。使用鱼鹰管道进行代谢物定量分析，并使用单变量和多变量方法进行分析。单因素分析显示，在高ace参与者中，ACC （p = 0.06）和PFC （p = 0.057）中n -乙酰氨基谷氨酸（NAAG）和sylo -肌醇（sI）水平分别降低。Logistic回归发现，ACC中NAAG、GABA、谷胱甘肽（GSH）和肌醇（mI）含量较低，PFC中sI、乳酸、NAAG和GSH含量差异较大。随机森林和支持向量机证实NAAG、mI和sI可能是ACE的生物标志物。在整个研究中，高ACE组的皮质区域一致显示NAAG、mI和sI水平降低，提示与ACE的潜在联系。这些发现提高了我们对与ACE相关的神经化学变化的理解，有助于识别高危人群，并制定预防长期健康影响的策略。

{"title":"Decreased levels of N-Acetylaspartyglutamate, myo-inositol, and syllo-inositol, in cortical brain regions of women exposed to adverse childhood experiences","authors":"Rocío Artigas , Sergio Ruiz , Cristián Montalba , Claudio Peñafiel , Rodrigo Figueroa , Pablo Irarrazaval","doi":"10.1016/j.mri.2026.110621","DOIUrl":"10.1016/j.mri.2026.110621","url":null,"abstract":"<div><div>Adverse Childhood Experiences (ACE), including abuse and neglect, can have lasting negative effects on health, decreasing lifespan and increasing the risk of chronic diseases. While research on ACE's impact on brain biochemistry is limited, Magnetic Resonance Spectroscopy (MRS) provides a non-invasive way to study these alterations. This study aims to identify neurochemical patterns linked to ACE exposure using J-edited MRS methods.</div><div>43 female participants (18 Low-ACE and 25 High-ACE), aged 19 to 31, were recruited. ACE exposure was assessed using the Maltreatment and Abuse Chronology of Exposure (MACE) test. MRS was conducted on a 3.0 T scanner, with J-edited single-voxel 1H-MRS from the Anterior Cingulate Cortex (ACC), Pre-Frontal Cortex (PFC), and hippocampus. Metabolite quantification was carried out using the Osprey pipeline and analyzed using univariate and multivariate methods.</div><div>Univariate analysis showed reduced N-Acetylaspartyglutamate (NAAG) and syllo-Inositol (sI) levels in the ACC (<em>p</em> = 0.06) and PFC (<em>p</em> = 0.057), respectively, among High-ACE participants. Logistic Regression identified lower NAAG, GABA, glutathione (GSH), and myo-Inositol (mI) in the ACC, and differences in sI, lactate, NAAG, and GSH in the PFC, within the High-ACE group. Random Forest and Support Vector Machines confirmed NAAG, mI, and sI as possible ACE biomarkers.</div><div>Throughout this study, cortical regions consistently showed reduced levels of NAAG, mI, and sI in the High-ACE group, suggesting a potential link to ACE. These findings improve our understanding of neurochemical changes associated with ACE, aiding in the identification of at-risk individuals and in the development of strategies to prevent long-term health effects.</div></div>","PeriodicalId":18165,"journal":{"name":"Magnetic resonance imaging","volume":"128 ","pages":"Article 110621"},"PeriodicalIF":2.0,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146030143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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