Letter to the Editor: Lack of association between classical HLA genes and asymptomatic SARS-CoV-2 infection.

IF 3.3 Q2 GENETICS & HEREDITY HGG Advances Pub Date : 2024-11-02 DOI:10.1016/j.xhgg.2024.100382
Eleanor Karp-Tatham, Callum R O'Neill, Julian C Knight, Alexander J Mentzer, Amanda Y Chong
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Abstract

Research into HLA-B*15:01 association with asymptomatic SARS-CoV-2 infection has so far yielded contradicting results. Using the UK Biobank cohort, we found a significant association between HLA-B*15:01 and asymptomatic infection. Our study adds more evidence for the complex role HLA alleles play in SARS-Cov-2 infection severity.

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致编辑的信:经典HLA基因与无症状SARS-CoV-2感染之间缺乏关联。
迄今为止,有关 HLA-B*15:01 与无症状 SARS-CoV-2 感染关系的研究结果相互矛盾。我们利用英国生物库队列发现,HLA-B*15:01 与无症状感染之间存在显著关联。我们的研究为 HLA 等位基因在 SARS-CoV-2 感染严重程度中所起的复杂作用提供了更多证据。
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来源期刊
HGG Advances
HGG Advances Biochemistry, Genetics and Molecular Biology-Molecular Medicine
CiteScore
4.30
自引率
4.50%
发文量
69
审稿时长
14 weeks
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