Abdel Azeim A. Khalaf , Mohamed A. Elhady , Marwa A. Ibrahim , Eman I. Hassanen , Rehab E. Abdelrahman , Peter A. Noshy
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引用次数: 0
Abstract
Ochratoxin A (OTA) is a mycotoxin that causes major health concerns in human and animals. Quercetin (QUE) is a flavonoid that possesses antioxidant, anti-inflammatory and anti-apoptotic properties. This report aims to investigate the ameliorative effects of QUE against OTA-induced hepatotoxicity in broiler chicken. Forty broiler chicks were equally allocated into 4 groups: Group I (control), Group II (OTA), Group III (QUE) and Group IV (OTA + QUE). OTA (0.5 mg/kg) and QUE (0.5 g/kg) were incorporated into the chicken feed for 42 days. The results presented a significant decrease in body weight and elevation in feed conversion ratio, and a significant elevation of the activities of serum alanine aminotransferase and aspartate aminotransferase enzymes in the OTA birds. Additionally, there was a significant decrease in catalase activity and reduced glutathione content and a significant elevation in malondialdehyde level in the liver of OTA-exposed birds. Various hepatocellular lesions were also noticed in the OTA-exposed birds. OTA exposure up-regulated the phosphatase and tensin homologue (PTEN) and the pro-apoptotic genes and down-regulated the anti-apoptotic genes in the liver. The addition of QUE ameliorated most of the hepatotoxic effects of OTA.
赭曲霉毒素 A（OTA）是一种霉菌毒素，对人类和动物的健康造成严重危害。槲皮素（QUE）是一种类黄酮，具有抗氧化、抗炎和抗细胞凋亡的特性。本报告旨在研究槲皮素对 OTA 引起的肉鸡肝中毒的改善作用。将 40 只肉鸡平均分为 4 组：第一组（对照组）、第二组（OTA）、第三组（QUE）和第四组（OTA+QUE）。在鸡饲料中添加 OTA（0.5 毫克/千克）和 QUE（0.5 克/千克），持续 42 天。结果显示，OTA 组鸡的体重明显下降，饲料转化率明显提高，血清丙氨酸氨基转移酶和天门冬氨酸氨基转移酶的活性明显升高。此外，受 OTA 影响的禽类肝脏中过氧化氢酶活性和还原型谷胱甘肽含量显著下降，丙二醛含量显著升高。暴露于 OTA 的鸟类还出现了各种肝细胞病变。暴露于 OTA 会上调肝脏中的磷酸酶和天丝同源物（PTEN）以及促凋亡基因，下调抗凋亡基因。添加 QUE 可改善 OTA 的大部分肝毒性效应。
期刊介绍：
Toxicon has an open access mirror Toxicon: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. An introductory offer Toxicon: X - full waiver of the Open Access fee.
Toxicon''s "aims and scope" are to publish:
-articles containing the results of original research on problems related to toxins derived from animals, plants and microorganisms
-papers on novel findings related to the chemical, pharmacological, toxicological, and immunological properties of natural toxins
-molecular biological studies of toxins and other genes from poisonous and venomous organisms that advance understanding of the role or function of toxins
-clinical observations on poisoning and envenoming where a new therapeutic principle has been proposed or a decidedly superior clinical result has been obtained.
-material on the use of toxins as tools in studying biological processes and material on subjects related to venom and antivenom problems.
-articles on the translational application of toxins, for example as drugs and insecticides
-epidemiological studies on envenoming or poisoning, so long as they highlight a previously unrecognised medical problem or provide insight into the prevention or medical treatment of envenoming or poisoning. Retrospective surveys of hospital records, especially those lacking species identification, will not be considered for publication. Properly designed prospective community-based surveys are strongly encouraged.
-articles describing well-known activities of venoms, such as antibacterial, anticancer, and analgesic activities of arachnid venoms, without any attempt to define the mechanism of action or purify the active component, will not be considered for publication in Toxicon.
-review articles on problems related to toxinology.
To encourage the exchange of ideas, sections of the journal may be devoted to Short Communications, Letters to the Editor and activities of the affiliated societies.
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