Differential induction of Parieto-motor plasticity in writer's cramp and cervical dystonia

IF 5.1 2区 医学 Q1 NEUROSCIENCES Neurobiology of Disease Pub Date : 2024-11-01 DOI:10.1016/j.nbd.2024.106724
Hyun Joo Cho , Hae-Won Shin , Pattamon Panyakaew , Panagiotis Kassavetis , Traian Popa , Tianxia Wu , Giorgio Leodori , Terance Camacho , Shivangi Singh , Sabine Meunier , Mark Hallett
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Abstract

Objectives

To investigate the plastic effects of parieto-motor (PAR-MOT) cortico-cortical paired associative paired stimulation (cc-PAS) in patients with two forms of focal dystonia, writer's cramp and cervical dystonia, compared to healthy volunteers (HVs).

Methods

We used cc-PAS to induce associative plasticity using repeated time-locked paired transcranial magnetic stimulation (TMS) pulses over the parietal and motor cortices in 16 patients with writer's cramp (WC), 13 patients with cervical dystonia (CD), and 23 healthy volunteers. We measured parieto-motor corticocortical connectivity using posterior parietal cortex (PPC) to primary motor cortex (M1) facilitation and input-output curves (IOC) of the motor-evoked potential (MEP) before and after PAR-MOT cc-PAS. The PAR-MOT cc-PAS consisted of 100 pairs of TMS pulses every 5 s, with the conditioning pulse applied to the left angular gyrus in the intraparietal sulcus and the test pulse applied to the M1 hotspot of the first dorsal interosseous muscle.

Results

The cc-PAS increased the area under the IOC by increasing its maximum level in patients with WC but not in patients with CD or healthy volunteers. The cc-PAS had no significant effect on other IOC parameters. There were no significant differences in PPC to M1 facilitation changes after PAR-MOT cc-PAS among all groups.

Conclusions

This study suggests that PAR-MOT cc-PAS abnormally increases M1 excitability in patients with WC but not in those with CD. Additionally, this increased plastic response in patients with WC does not appear to be directly linked to PPC to M1 corticocortical connectivity.
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作家痉挛和颈肌张力障碍对副运动可塑性的不同诱导作用
研究目的研究顶叶-运动(PAR-MOT)皮层-皮层成对联想刺激(cc-PAS)对两种局灶性肌张力障碍(作家痉挛和颈性肌张力障碍)患者与健康志愿者(HVs)的可塑性影响:我们使用cc-PAS对16名写作痉挛(WC)患者、13名颈肌张力障碍(CD)患者和23名健康志愿者的顶叶和运动皮层进行重复锁时配对经颅磁刺激(TMS)脉冲,诱导他们产生联想可塑性。在 PAR-MOT cc-PAS 之前和之后,我们使用顶叶后皮层(PPC)到初级运动皮层(M1)的促进作用和运动诱发电位(MEP)的输入-输出曲线(IOC)测量了顶叶-运动皮层的连通性。PAR-MOT cc-PAS由100对TMS脉冲组成,每5秒一次,调节脉冲作用于顶内沟左侧角回,测试脉冲作用于第一背侧骨间肌的M1热点:cc-PAS增加了WC患者的IOC下面积,提高了其最大值,但对CD患者或健康志愿者没有影响。cc-PAS对其他IOC参数没有明显影响。PAR-MOT cc-PAS后,PPC对M1的促进作用在各组间无明显差异:本研究表明,PAR-MOT cc-PAS 会异常增加 WC 患者的 M1 兴奋性,但 CD 患者不会。此外,WC 患者的这种可塑性反应的增加似乎与 PAR-MOT cc-PAS 与 M1 皮层连接没有直接联系。
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来源期刊
Neurobiology of Disease
Neurobiology of Disease 医学-神经科学
CiteScore
11.20
自引率
3.30%
发文量
270
审稿时长
76 days
期刊介绍: Neurobiology of Disease is a major international journal at the interface between basic and clinical neuroscience. The journal provides a forum for the publication of top quality research papers on: molecular and cellular definitions of disease mechanisms, the neural systems and underpinning behavioral disorders, the genetics of inherited neurological and psychiatric diseases, nervous system aging, and findings relevant to the development of new therapies.
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