Neurostructural features predict binge drinking in emerging adulthood: Evidence from a 5-year follow-up study

IF 3.9 2区 医学 Q1 PSYCHIATRY Drug and alcohol dependence Pub Date : 2024-10-30 DOI:10.1016/j.drugalcdep.2024.112489
Jose Manuel Pérez-García , Samuel Suárez-Suárez , María Soledad Rodríguez González , Socorro Rodríguez Holguín , Fernando Cadaveira , Sonia Doallo
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Abstract

Background

Binge drinking (BD) involves consuming large amounts of alcohol within a short timeframe, leading to a blood alcohol concentration of 0.08 g/dL or above. This pattern of alcohol consumption is prevalent among young adults and has significant implications for brain structure and subsequent drinking behaviors.

Methods

In this prospective longitudinal study, we employed zero-inflated negative binomial regression models to examine whether various neurostructural features (i.e., volume, surface area, cortical thickness) of brain regions involved in executive and emotional/motivational processes at the age of 18–19 could predict number of BD episodes five years later, at ages 23–24, once participants were expected to complete their university degree. Specifically, we recorded magnetic resonance imaging (MRI) data from 68 students who completed both the baseline MRI and follow-up alcohol use assessment, with the aim of analyzing the predictive value of these neurostructural characteristics five years later.

Results

The analysis revealed that a larger surface area in the caudal division of the right middle frontal gyrus was significantly associated with a higher incidence rate of BD episodes (IRR = 2.24, 95 % CI = 1.28–3.91, p = 0.005). Conversely, a smaller surface area in the right caudal anterior cingulate cortex was associated with a higher incidence rate of BD episodes (IRR = 0.61, 95 % CI = 0.44–0.85, p = 0.004).

Conclusions

These findings suggest that specific neurostructural characteristics during adolescence can predict BD behaviors in young adulthood. This highlights the potential of neuroimaging to identify individuals at risk for developing problematic alcohol use.
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神经结构特征可预测成年后的酗酒行为:一项为期 5 年的跟踪研究提供的证据。
背景:暴饮(BD)是指在短时间内大量饮酒,导致血液中酒精浓度达到或超过 0.08g/dL。这种饮酒模式在年轻人中很普遍,对大脑结构和随后的饮酒行为有重大影响:在这项前瞻性纵向研究中,我们采用了零膨胀负二项回归模型,以考察参与执行过程和情绪/动机过程的脑区在 18-19 岁时的各种神经结构特征(即体积、表面积、皮质厚度)是否能预测五年后,即 23-24 岁时的 BD 发作次数,因为参与者预计将完成大学学业。具体来说,我们记录了 68 名学生的磁共振成像(MRI)数据,这些学生同时完成了基线磁共振成像和后续酒精使用评估,目的是分析这些神经结构特征对五年后的预测价值:分析结果显示,右侧额叶中回尾部的面积越大,BD发作率越高(IRR = 2.24,95 % CI = 1.28-3.91,p = 0.005)。相反,右侧尾状前扣带回皮层的表面积越小,BD发病率越高(IRR = 0.61,95 % CI = 0.44-0.85,p = 0.004):这些研究结果表明,青春期的特定神经结构特征可以预测成年后的BD行为。结论:这些研究结果表明,青少年时期的特定神经结构特征可预测青少年成年后的BD行为,这凸显了神经影像学在识别有酗酒问题的高危人群方面的潜力。
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来源期刊
Drug and alcohol dependence
Drug and alcohol dependence 医学-精神病学
CiteScore
7.40
自引率
7.10%
发文量
409
审稿时长
41 days
期刊介绍: Drug and Alcohol Dependence is an international journal devoted to publishing original research, scholarly reviews, commentaries, and policy analyses in the area of drug, alcohol and tobacco use and dependence. Articles range from studies of the chemistry of substances of abuse, their actions at molecular and cellular sites, in vitro and in vivo investigations of their biochemical, pharmacological and behavioural actions, laboratory-based and clinical research in humans, substance abuse treatment and prevention research, and studies employing methods from epidemiology, sociology, and economics.
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