Bioengineered human arterial equivalent and its applications from vascular graft to in vitro disease modeling

IF 4.6 2区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES iScience Pub Date : 2024-10-19 DOI:10.1016/j.isci.2024.111215

Xi Luo , Zherui Pang , Jinhua Li , Minjun Anh , Byoung Soo Kim , Ge Gao

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Abstract

Arterial disorders such as atherosclerosis, thrombosis, and aneurysm pose significant health risks, necessitating advanced interventions. Despite progress in artificial blood vessels and animal models aimed at understanding pathogenesis and developing therapies, limitations in graft functionality and species discrepancies restrict their clinical and research utility. Addressing these issues, bioengineered arterial equivalents (AEs) with enhanced vascular functions have been developed, incorporating innovative technologies that improve clinical outcomes and enhance disease progression modeling. This review offers a comprehensive overview of recent advancements in bioengineered AEs, systematically summarizing the bioengineered technologies used to construct these AEs, and discussing their implications for clinical application and pathogenesis understanding. Highlighting current breakthroughs and future perspectives, this review aims to inform and inspire ongoing research in the field, potentially transforming vascular medicine and offering new avenues for preclinical and clinical advances.

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生物工程人体动脉等效物及其应用（从血管移植到体外疾病建模

动脉粥样硬化、血栓形成和动脉瘤等动脉疾病对健康构成重大威胁，因此必须采取先进的干预措施。尽管人造血管和动物模型在了解发病机理和开发疗法方面取得了进展，但移植物功能的局限性和物种差异限制了其临床和研究用途。为了解决这些问题，人们开发出了具有增强血管功能的生物工程动脉等效物（AE），并将创新技术融入其中，以改善临床效果并增强疾病进展模型。本综述全面概述了生物工程动脉等值物的最新进展，系统总结了用于构建这些等值物的生物工程技术，并讨论了它们对临床应用和发病机理理解的影响。本综述强调了当前的突破和未来的前景，旨在为该领域正在进行的研究提供信息和启发，从而有可能改变血管医学，为临床前和临床进展提供新的途径。

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来源期刊

iScience Multidisciplinary-Multidisciplinary

CiteScore

7.20

自引率

1.70%

发文量

1972

审稿时长

6 weeks

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