Soroush Zaheri-Ghannad , Vahid Kordzadeh-Kermani , Masoud Madadelahi
{"title":"Cell/particle manipulation using Bulk Acoustic Waves (BAWs) on centrifugal microfluidic platforms: A mathematical study","authors":"Soroush Zaheri-Ghannad , Vahid Kordzadeh-Kermani , Masoud Madadelahi","doi":"10.1016/j.cep.2024.110024","DOIUrl":null,"url":null,"abstract":"<div><div>This study presents an integrated acoustic-aided centrifugal microfluidic system to focus and separate microparticles. A 3D numerical simulation was conducted to analyze microparticle movement by exploiting the simultaneous imposition of centrifugal forces and bulk acoustic waves (BAWs) on an electrified lab-on-a-disc device (eLOD). Accordingly, the movement of microparticles was analyzed in a radially positioned rectangular microchannel at various rotation speeds. The effect of physical parameters, including the distance of the microchannel to the center/radius, tilting angle (<em>α</em>), the oscillation amplitude of BAWs, the microchannel's dimension, and the particles’ diameter on particle trajectories and focusing efficiency, was studied. It was found that properly adjusting the microchannel's placement at <em>α</em> = 30° made it possible to direct the focused stream of microparticles toward the desired outlet. Higher values of applied oscillation amplitude of BAWs (0.3 nm) led to perfect focusing of microparticles toward the middle outlet in a 200-µm width microchannel at 80 rad/s rotation. Furthermore, the system's ability to separate the circulating tumor cells (CTC) from white blood cells (WBC) was also simulated. The results showed that a successful size-based separation of these bioparticles is achievable by adequately adjusting the microchannel's position or tilting angle at 286 rpm.</div></div>","PeriodicalId":9929,"journal":{"name":"Chemical Engineering and Processing - Process Intensification","volume":null,"pages":null},"PeriodicalIF":3.8000,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemical Engineering and Processing - Process Intensification","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0255270124003623","RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ENERGY & FUELS","Score":null,"Total":0}
引用次数: 0
Abstract
This study presents an integrated acoustic-aided centrifugal microfluidic system to focus and separate microparticles. A 3D numerical simulation was conducted to analyze microparticle movement by exploiting the simultaneous imposition of centrifugal forces and bulk acoustic waves (BAWs) on an electrified lab-on-a-disc device (eLOD). Accordingly, the movement of microparticles was analyzed in a radially positioned rectangular microchannel at various rotation speeds. The effect of physical parameters, including the distance of the microchannel to the center/radius, tilting angle (α), the oscillation amplitude of BAWs, the microchannel's dimension, and the particles’ diameter on particle trajectories and focusing efficiency, was studied. It was found that properly adjusting the microchannel's placement at α = 30° made it possible to direct the focused stream of microparticles toward the desired outlet. Higher values of applied oscillation amplitude of BAWs (0.3 nm) led to perfect focusing of microparticles toward the middle outlet in a 200-µm width microchannel at 80 rad/s rotation. Furthermore, the system's ability to separate the circulating tumor cells (CTC) from white blood cells (WBC) was also simulated. The results showed that a successful size-based separation of these bioparticles is achievable by adequately adjusting the microchannel's position or tilting angle at 286 rpm.
期刊介绍:
Chemical Engineering and Processing: Process Intensification is intended for practicing researchers in industry and academia, working in the field of Process Engineering and related to the subject of Process Intensification.Articles published in the Journal demonstrate how novel discoveries, developments and theories in the field of Process Engineering and in particular Process Intensification may be used for analysis and design of innovative equipment and processing methods with substantially improved sustainability, efficiency and environmental performance.