Association between the oxidative balance score with metabolic syndrome traits in US adults.

IF 3.4 3区 医学 Q2 ENDOCRINOLOGY & METABOLISM Diabetology & Metabolic Syndrome Pub Date : 2024-11-05 DOI:10.1186/s13098-024-01500-y
Junxian Li, Ya Liu, Jingjing Li, Ziwei Feng, Lili Bai, Yujie Feng, Pengyu Zhang, Fengju Song
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Abstract

Objective: To explore the association between the Oxidative Balance Score (OBS), which represents the balance of multiple oxidative stress-related dietary and lifestyle exposures, and the risk of metabolic syndrome (MetS).

Methods: A population-based cross-sectional study design was adopted and 16,850 participants in NHANES database were included in the statistics analysis stage. The OBS was constructed by combining information from 20 a priori selected pro- and antioxidant factors. Weighted logistic regression and restricted cubic splines (RCS) were used to estimate the association between OBS and MetS.

Results: Participants in the highest OBS quartile, indicating low oxidative stress (OS) levels, exhibited a significantly lower risk of MetS (odds Ratio [OR] = 0.55, 95% confidence Interval [CI]: 0.47-0.64) compared to the lowest quartile. Specifically, higher OBS was inversely associated with abdominal obesity (OR = 0.61, 95% CI: 0.54-0.69), hypertension (OR = 0.69, 95% CI: 0.58-0.83), elevated triglycerides (OR = 0.68, 95% CI: 0.57-0.82), low high-density lipoprotein cholesterol (HDL-C) levels (OR = 0.60, 95% CI: 0.50-0.70) and fasting blood glucose (FBG) levels (OR = 0.74, 95% CI: 0.62-0.88). The observed inverse association between OBS and hypertension or FBG levels appeared to primarily influenced by BMI. The association between dietary OBS intervals and elevated FBG levels was not statistically significant in men, whereas the risk was lower by 25% in women.

Conclusions: A higher OBS, representing a balance of multiple oxidative stress-related dietary and lifestyle exposures, is associated with a lower risk of MetS. Therefore, adhering to an antioxidant diet and lifestyle may help prevent the occurrence of metabolic disorders.

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美国成年人氧化平衡评分与代谢综合征特征之间的关系。
目的:探讨氧化平衡评分(OBS)与代谢综合征(MetS)风险之间的关系:探讨氧化平衡评分(OBS)与代谢综合征(MetS)风险之间的关系:方法:采用基于人群的横断面研究设计,在统计分析阶段纳入 16 850 名 NHANES 数据库参与者。OBS由20个先验选定的促抗氧化因子的信息组合而成。研究采用加权逻辑回归和限制性立方样条(RCS)来估计OBS与MetS之间的关系:结果:与最低四分位数相比,OBS最高四分位数(表明氧化应激(OS)水平较低)的参与者患 MetS 的风险明显较低(几率比 [OR] = 0.55,95% 置信区间 [CI]:0.47-0.64)。具体来说,较高的 OBS 与腹部肥胖(OR = 0.61,95% CI:0.54-0.69)、高血压(OR = 0.69,95% CI:0.58-0.83)、甘油三酯升高(OR = 0.68,95% CI:0.57-0.82)、低高密度脂蛋白胆固醇(HDL-C)水平(OR = 0.60,95% CI:0.50-0.70)和空腹血糖(FBG)水平(OR = 0.74,95% CI:0.62-0.88)。观察到的 OBS 与高血压或 FBG 水平之间的负相关似乎主要受体重指数(BMI)的影响。膳食 OBS 间隔与 FBG 水平升高之间的关系在男性中没有统计学意义,而在女性中风险降低了 25%:结论:较高的 OBS(代表多种氧化应激相关饮食和生活方式暴露的平衡)与较低的 MetS 风险相关。因此,坚持抗氧化饮食和生活方式有助于预防代谢紊乱的发生。
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来源期刊
Diabetology & Metabolic Syndrome
Diabetology & Metabolic Syndrome ENDOCRINOLOGY & METABOLISM-
CiteScore
6.20
自引率
0.00%
发文量
170
审稿时长
7.5 months
期刊介绍: Diabetology & Metabolic Syndrome publishes articles on all aspects of the pathophysiology of diabetes and metabolic syndrome. By publishing original material exploring any area of laboratory, animal or clinical research into diabetes and metabolic syndrome, the journal offers a high-visibility forum for new insights and discussions into the issues of importance to the relevant community.
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