Impact of oral isotretinoin on the inflammatory markers: can lymphocyte/HDL-C and platelet/HDL-C ratios be new indicators of inflammation in acne vulgaris patients?

IF 1.6 4区 医学 Q3 OPHTHALMOLOGY Cutaneous and Ocular Toxicology Pub Date : 2024-11-05 DOI:10.1080/15569527.2024.2423257
Özge Zorlu, Hülya Albayrak, Sema Aytekin
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Abstract

Introduction: The effect of isotretinoin on inflammatory markers has been reported with conflicting results. No studies have been reported on the relationship between isotretinoin and lymphocyte/high-density lipoprotein cholesterol [HDL-C] ratio (LHR), neutrophil/HDL-C ratio (NHR), or platelet/HDL-C ratio (PHR) in acne patients.

Objectives: We aimed to investigate how isotretinoin affects the inflammatory markers, including LHR, NHR, and PHR, in acne vulgaris patients.

Methods: A total of 361 patients with moderate-to-severe acne vulgaris who received systemic isotretinoin for at least six months were included. Complete blood count and biochemical analyses, including monocyte/HDL-C ratio (MHR), NHR, LHR, PHR, neutrophil/lymphocyte ratio (NLR), monocyte/lymphocyte ratio (MLR), platelet/lymphocyte ratio (PLR), the aggregate index of systemic inflammation (AISI), systemic immune-inflammation index (SII), and systemic inflammation response index (SIRI), obtained at the treatment onset and the end of the first, third, and sixth months of treatment were investigated.

Results: There was no significant difference in MHR and NHR levels between repeated measures. A significant increasing trend was seen in LHR and PHR (P = 0.001 and P = 0.011, respectively). HDL-C levels gradually and significantly declined during the six months (P < 0.001). Serum NLR, derived NLR, SII, SIRI, MLR, and AISI showed a significant decrease in line with clinical improvement in acne during the six months of therapy (P < 0.05).

Conclusions: Declining levels of NLR, MLR, SII, SIRI, and AISI may indicate the anti-inflammatory effects of isotretinoin on the pilosebaceous unit, whereas increasing levels of LHR and PHR may show systemic inflammatory activity of isotretinoin.

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口服异维A酸对炎症指标的影响:淋巴细胞/高密度脂蛋白胆固醇(HDL-C)和血小板/高密度脂蛋白胆固醇(HDL-C)比率能否成为寻常型痤疮患者炎症的新指标?
简介异维A酸对炎症指标的影响已有报道,但结果不尽相同。目前还没有关于异维A酸与痤疮患者淋巴细胞/高密度脂蛋白胆固醇[HDL-C]比率(LHR)、中性粒细胞/HDL-C比率(NHR)或血小板/HDL-C比率(PHR)之间关系的研究报告:我们旨在研究异维A酸如何影响寻常型痤疮患者的炎症指标,包括LHR、NHR和PHR:方法:共纳入 361 名接受异维A酸治疗至少六个月的中重度寻常型痤疮患者。全血细胞计数和生化分析,包括单核细胞/高密度脂蛋白胆固醇比率(MHR)、NHR、LHR、PHR、中性粒细胞/淋巴细胞比率(NLR)、单核细胞/淋巴细胞比率(MLR)、血小板/淋巴细胞比率(PLR)、全身炎症综合指数(AISI)、研究了治疗开始时以及治疗第一、第三和第六个月结束时获得的全身免疫炎症指数(SII)和全身炎症反应指数(SIRI)。结果显示重复测量的 MHR 和 NHR 水平无明显差异。LHR和PHR呈明显上升趋势(分别为P = 0.001和P = 0.011)。在这六个月中,HDL-C 水平逐渐明显下降(P P 结论):NLR、MLR、SII、SIRI 和 AISI 水平的下降可能表明异维A酸对皮脂腺具有抗炎作用,而 LHR 和 PHR 水平的上升可能表明异维A酸具有全身炎症活性。
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来源期刊
CiteScore
3.30
自引率
6.20%
发文量
40
审稿时长
1 months
期刊介绍: Cutaneous and Ocular Toxicology is an international, peer-reviewed journal that covers all types of harm to cutaneous and ocular systems. Areas of particular interest include pharmaceutical and medical products; consumer, personal care, and household products; and issues in environmental and occupational exposures. In addition to original research papers, reviews and short communications are invited, as well as concise, relevant, and critical reviews of topics of contemporary significance.
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