Accuracy of mitral annular plane systolic excursion in diagnosing anthracycline-induced subclinical cardiotoxicity in patients with breast cancer - a retrospective cohort study.

IF 3.2 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Cardio-oncology Pub Date : 2024-11-04 DOI:10.1186/s40959-024-00280-8
Luís Fábio Barbosa Botelho, Marcelo Dantas Tavares de Melo, André Luiz Cerqueira de Almeida, Vera Maria Cury Salemi
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Abstract

Background: The mitral annular plane systolic excursion (MAPSE) is used to analyze the left ventricle longitudinal function. However, the accuracy of MAPSE in diagnosing oncological populations is unclear. In this study, we aimed to assess the accuracy of MAPSE in diagnosing subclinical cardiotoxicity in women with breast cancer undergoing anthracycline treatment.

Methods: This retrospective cohort study included echocardiographic assessments of patients with breast cancer who underwent anthracycline treatment as part of their therapeutic regimen. Assessments were performed before treatment, after administering the first dose of anthracycline, after completing anthracycline treatment, and 6 and 12 months after treatment. Left ventricular ejection fraction was calculated using the modified biplane Simpson method. The performances of MAPSE and global longitudinal strain (GLS) were analyzed using receiver operating characteristic (ROC) curves. Their accuracies were measured using the area under the ROC curves.

Results: Sixty-one patients were included in this study. Of them, 8.2% presented cardiotoxicity 6 months after treatment completion. Patients with cardiotoxicity had lower LVEF (47% vs. 63%; p < 0.001), MAPSE (10.23 mm vs. 12.25 mm; p = 0.012), and LV GLS (16.13% vs. 19.05%; p = 0.005) values than those without. A 12% reduction in the GLS exhibited sensitivity, specificity, and overall accuracy of 80%, 70%, and 78%, respectively. A relative reduction of 15% in MAPSE exhibited a sensitivity, specificity, and accuracy of 80%, 77%, and 81.2%, respectively. An absolute MAPSE reduction of 2 mm exhibited a sensitivity, specificity, and accuracy of 80%, 73.21%, and 81.2%, respectively. No differences were observed between the ROC curves.

Conclusion: MAPSE showed similar accuracy to GLS in diagnosing subclinical cardiotoxicity in women with breast cancer undergoing anthracycline treatment.

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二尖瓣环平面收缩期偏移在诊断乳腺癌患者由蒽环类药物引起的亚临床心脏毒性方面的准确性--一项回顾性队列研究。
背景:二尖瓣环平面收缩期偏移(MAPSE)用于分析左心室纵向功能。然而,MAPSE 诊断肿瘤人群的准确性尚不明确。本研究旨在评估 MAPSE 在诊断接受蒽环类药物治疗的乳腺癌女性患者亚临床心脏毒性方面的准确性:这项回顾性队列研究包括对接受蒽环类药物治疗的乳腺癌患者进行超声心动图评估。评估分别在治疗前、首剂蒽环类药物治疗后、蒽环类药物治疗结束后以及治疗后 6 个月和 12 个月进行。采用改良双平面辛普森法计算左心室射血分数。使用接收器操作特征曲线(ROC)分析了 MAPSE 和整体纵向应变(GLS)的性能。结果:本研究共纳入 61 名患者。其中,8.2%的患者在治疗结束后6个月出现心脏毒性。心脏毒性患者的 LVEF 较低(47% 对 63%;P 结论:MAPSE 与 GLS 的准确性相似:在诊断接受蒽环类药物治疗的乳腺癌女性患者的亚临床心脏毒性方面,MAPSE与GLS显示出相似的准确性。
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来源期刊
Cardio-oncology
Cardio-oncology Medicine-Cardiology and Cardiovascular Medicine
CiteScore
5.00
自引率
3.00%
发文量
17
审稿时长
7 weeks
期刊最新文献
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