Recent Developments in Using Microneedle Patch Technology as a More Efficient Drug Delivery System for Treating Skin Photoaging.

IF 1.9 4区医学 Q3 DERMATOLOGY Clinical, Cosmetic and Investigational Dermatology Pub Date : 2024-10-31 eCollection Date: 2024-01-01 DOI:10.2147/CCID.S492774

Xiong Lv, Chun Xiang, Yan Zheng, Wan-Xuan Zhou, Xu-Ling Lv

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Abstract

Skin photoaging, resulting from prolonged exposure to ultraviolet (UV) radiation, is characterized by intricate biological changes involving oxidative damage and structural alterations. Despite an increasing demand for effective interventions, the current therapeutic options for treating skin photoaging are limited. We discovered through literature data search on PubMed that recent research has shifted its focus to the application of microneedle patches as an innovative approach to address this concern. Microneedle patches, serving as a novel transdermal delivery system, exhibit the potential to deliver bioactive substances such as cytokines, cellular vesicles, gene fragments and even alive algae to mitigate the effects of skin photoaging. This review aims to provide a comprehensive overview of recent advancements in research about utilizing microneedle patches for the treatment of skin photoaging and potential future directions in leveraging microneedle patches as clinical therapeutic agents for skin rejuvenation. Ultimately, we believe that microneedle patches have a broader application prospect in the fields of medical cosmetology and anti-photoaging.

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将微针贴片技术作为治疗皮肤光老化的更高效给药系统的最新进展。

皮肤光老化是由于皮肤长期暴露在紫外线（UV）辐射下造成的，其特点是发生复杂的生物变化，包括氧化损伤和结构改变。尽管对有效干预措施的需求与日俱增，但目前治疗皮肤光老化的方法却很有限。通过在 PubMed 上进行文献数据检索，我们发现最近的研究已将重点转移到微针贴片的应用上，将其作为解决这一问题的创新方法。微针贴片作为一种新型透皮给药系统，具有给药生物活性物质（如细胞因子、细胞囊泡、基因片段甚至活海藻）的潜力，可减轻皮肤光老化的影响。本综述旨在全面概述利用微针贴片治疗皮肤光老化的最新研究进展，以及利用微针贴片作为皮肤年轻化临床治疗剂的潜在未来方向。最终，我们相信微针贴片在医学美容和抗光老化领域具有更广阔的应用前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical, Cosmetic and Investigational Dermatology Medicine-Dermatology

CiteScore

2.80

自引率

4.30%

发文量

353

审稿时长

16 weeks

期刊介绍： Clinical, Cosmetic and Investigational Dermatology is an international, peer-reviewed, open access journal that focuses on the latest clinical and experimental research in all aspects of skin disease and cosmetic interventions. Normal and pathological processes in skin development and aging, their modification and treatment, as well as basic research into histology of dermal and dermal structures that provide clinical insights and potential treatment options are key topics for the journal. Patient satisfaction, preference, quality of life, compliance, persistence and their role in developing new management options to optimize outcomes for target conditions constitute major areas of interest. The journal is characterized by the rapid reporting of clinical studies, reviews and original research in skin research and skin care. All areas of dermatology will be covered; contributions will be welcomed from all clinicians and basic science researchers globally.