Extended oxygen supplementation after thoracotomy in rats may improve welfare.

IF 1.3 4区农林科学 Q2 VETERINARY SCIENCES Laboratory Animals Pub Date : 2025-04-01 Epub Date: 2024-11-04 DOI:10.1177/00236772241273061

Bryony Few, Alex Dugdale

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Abstract

A retrospective comparison of welfare indicators in male rats undergoing thoracotomy for intrapleural dosing is presented. The initial cohort (n = 7) breathed room air after recovery from anaesthesia, while later cohorts (n = 12) had oxygen supplementation for up to 48 h post-surgery. Rats breathing room air sustained a statistically significant average body-weight loss of -1.62% (±1.7%) 2 days after surgery, compared with rats given oxygen supplementation, which maintained a mean weight gain of 0.87% (±1.75%) (p = 0.009). Oxygen-supplemented rats also had lower pain scores on the evening after surgery (median 0.075 [range 0-1.75] vs. median 1.5 [range 0.5-2]). This difference was not statistically significant (p = 0.063) but may be of clinical significance. All rats displayed transient sedation after post-operative opioid administration on the day of surgery, and hypoxaemia (SpO₂ <90%) was observed in rats maintained on room air. Use of an oxygen concentrator to provide post-operative extended oxygen supplementation was easy to implement and may improve animal welfare post-thoracotomy.

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大鼠胸廓切开术后延长氧气补充时间可改善福利。

本文对接受胸廓切开术进行胸腔内给药的雄性大鼠的福利指标进行了回顾性比较。最初的一组大鼠（n = 7）在麻醉恢复后呼吸室内空气，而后来的一组大鼠（n = 12）在手术后48小时内补充氧气。与补充氧气的大鼠相比，呼吸室内空气的大鼠在术后 2 天平均体重下降了-1.62%（±1.7%），而补充氧气的大鼠平均体重增加了 0.87%（±1.75%）（p = 0.009）。手术后当晚，补氧大鼠的疼痛评分也较低（中位数 0.075 [范围 0-1.75] 与中位数 1.5 [范围 0.5-2]）。这一差异没有统计学意义（p = 0.063），但可能具有临床意义。手术当天，所有大鼠在术后服用阿片类药物后都表现出短暂的镇静，并出现低氧血症（SpO2

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来源期刊

Laboratory Animals 生物-动物学

CiteScore

4.90

自引率

8.30%

发文量

审稿时长

6-12 weeks

期刊介绍： The international journal of laboratory animal science and welfare, Laboratory Animals publishes peer-reviewed original papers and reviews on all aspects of the use of animals in biomedical research. The journal promotes improvements in the welfare or well-being of the animals used, it particularly focuses on research that reduces the number of animals used or which replaces animal models with in vitro alternatives.