{"title":"Zuranolone: A Rapidly Acting Oral Neuroactive Steroid Antidepressant for the Treatment of Postpartum Depression.","authors":"Karan Kverno, Fatima Ramos-Marcuse","doi":"10.3928/02793695-20241015-02","DOIUrl":null,"url":null,"abstract":"<p><p>Severe depression, anxiety, and mood dysregulation during pregnancy and postpartum are risk factors for the safety and health of mother and baby. Current best practice guidelines recommend screening for depressive and anxiety symptoms before and during pregnancy, in addition to the postpartum period. Rapid identification and treatment of depression has the potential to be life-saving and prevent deleterious consequences, including impaired mother-infant bonding, emotional dysregulation, and other developmental problems. The current article reviews the neurobiological mechanisms of postpartum depression and a novel rapidly acting oral pharmacotherapeutic neuroactive steroid, zuranolone. [<i>Journal of Psychosocial Nursing and Mental Health Services, 62</i>(11), 7-10.].</p>","PeriodicalId":50071,"journal":{"name":"Journal of Psychosocial Nursing and Mental Health Services","volume":null,"pages":null},"PeriodicalIF":1.2000,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Psychosocial Nursing and Mental Health Services","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3928/02793695-20241015-02","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"NURSING","Score":null,"Total":0}
引用次数: 0
Abstract
Severe depression, anxiety, and mood dysregulation during pregnancy and postpartum are risk factors for the safety and health of mother and baby. Current best practice guidelines recommend screening for depressive and anxiety symptoms before and during pregnancy, in addition to the postpartum period. Rapid identification and treatment of depression has the potential to be life-saving and prevent deleterious consequences, including impaired mother-infant bonding, emotional dysregulation, and other developmental problems. The current article reviews the neurobiological mechanisms of postpartum depression and a novel rapidly acting oral pharmacotherapeutic neuroactive steroid, zuranolone. [Journal of Psychosocial Nursing and Mental Health Services, 62(11), 7-10.].
孕期和产后严重的抑郁、焦虑和情绪失调是影响母婴安全和健康的危险因素。目前的最佳实践指南建议，除产后筛查外，还应在孕前和孕期筛查抑郁和焦虑症状。快速识别和治疗抑郁症有可能挽救生命并防止有害后果的发生，包括母婴关系受损、情绪失调和其他发育问题。本文回顾了产后抑郁症的神经生物学机制，以及一种新型快速起效的口服药物神经活性类固醇--莪术酮。[社会心理护理和心理健康服务期刊》（Journal of Psychosocial Nursing and Mental Health Services），62（11），7-10。
期刊介绍：
The Journal of Psychosocial Nursing and Mental Health Services is a peer-reviewed, monthly journal for psychosocial and mental health nurses in a variety of community and institutional settings. For more than 50 years, the Journal has provided the most up-to-date, practical information available for today’s psychosocial-mental health nurse, including short contributions about psychopharmacology, mental health care of older adults, addictive behaviors and diagnoses, and child/adolescent disorders and issues. Begin to explore the Journal and all of its great benefits such as:
• Monthly feature, “Clip & Save: Drug Chart,” a one-page resource of up-to-date information on current medications for various psychiatric illnesses
• Access to current articles, as well as several years of archived content
• Articles posted online just 2 months after acceptance
• Continuing Nursing Education credits available each month
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