Chronic Overlapping Pain Conditions and Nociplastic Pain.

IF 3.3 Q2 GENETICS & HEREDITY HGG Advances Pub Date : 2024-11-04 DOI:10.1016/j.xhgg.2024.100381
Keira J A Johnston, Rebecca Signer, Laura M Huckins
{"title":"Chronic Overlapping Pain Conditions and Nociplastic Pain.","authors":"Keira J A Johnston, Rebecca Signer, Laura M Huckins","doi":"10.1016/j.xhgg.2024.100381","DOIUrl":null,"url":null,"abstract":"<p><p>Chronic Overlapping Pain Conditions (COPCs) are a subset of chronic pain conditions commonly comorbid with one another and more prevalent in women and assigned female at birth (AFAB) individuals. Pain experience in these conditions may better fit with a new mechanistic pain descriptor, nociplastic pain, and nociplastic pain may represent a shared underlying factor among COPCs. We applied GenomicSEM common-factor genome wide association study (GWAS) and multivariate transcriptome-wide association (TWAS) analyses to existing GWAS output for six COPCs in order to find genetic variation associated with nociplastic pain, followed by genetic correlation (linkage-disequilibrium score regression), gene-set and tissue enrichment analyses. We found 24 independent single nucleotide polymorphisms (SNPs), and 127 unique genes significantly associated with nociplastic pain, and showed nociplastic pain to be a polygenic trait with significant SNP-heritability. We found significant genetic overlap between multisite chronic pain and nociplastic pain, and to a smaller extent with rheumatoid arthritis and a neuropathic pain phenotype. Tissue enrichment analyses highlighted cardiac and thyroid tissue, and gene set enrichment analyses emphasized potential shared mechanisms in cognitive, personality, and metabolic traits and nociplastic pain along with distinct pathology in migraine and headache. We use a well-powered network approach to investigate nociplastic pain using existing COPC GWAS output, and show nociplastic pain to be a complex, heritable trait, in addition to contributing to understanding of potential mechanisms in development of nociplastic pain.</p>","PeriodicalId":34530,"journal":{"name":"HGG Advances","volume":null,"pages":null},"PeriodicalIF":3.3000,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"HGG Advances","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1016/j.xhgg.2024.100381","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"GENETICS & HEREDITY","Score":null,"Total":0}
引用次数: 0

Abstract

Chronic Overlapping Pain Conditions (COPCs) are a subset of chronic pain conditions commonly comorbid with one another and more prevalent in women and assigned female at birth (AFAB) individuals. Pain experience in these conditions may better fit with a new mechanistic pain descriptor, nociplastic pain, and nociplastic pain may represent a shared underlying factor among COPCs. We applied GenomicSEM common-factor genome wide association study (GWAS) and multivariate transcriptome-wide association (TWAS) analyses to existing GWAS output for six COPCs in order to find genetic variation associated with nociplastic pain, followed by genetic correlation (linkage-disequilibrium score regression), gene-set and tissue enrichment analyses. We found 24 independent single nucleotide polymorphisms (SNPs), and 127 unique genes significantly associated with nociplastic pain, and showed nociplastic pain to be a polygenic trait with significant SNP-heritability. We found significant genetic overlap between multisite chronic pain and nociplastic pain, and to a smaller extent with rheumatoid arthritis and a neuropathic pain phenotype. Tissue enrichment analyses highlighted cardiac and thyroid tissue, and gene set enrichment analyses emphasized potential shared mechanisms in cognitive, personality, and metabolic traits and nociplastic pain along with distinct pathology in migraine and headache. We use a well-powered network approach to investigate nociplastic pain using existing COPC GWAS output, and show nociplastic pain to be a complex, heritable trait, in addition to contributing to understanding of potential mechanisms in development of nociplastic pain.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
慢性重叠性疼痛病症和 Nociplastic 疼痛。
慢性重叠性疼痛病症(COPCs)是慢性疼痛病症的一个子集,通常相互并发,在女性和出生时被指定为女性(AFAB)的人中更为常见。这些病症的疼痛体验可能更符合新的疼痛机制描述--非痉挛性疼痛,而非痉挛性疼痛可能代表了 COPCs 的共同潜在因素。我们将 GenomicSEM 共因子全基因组关联研究(GWAS)和多变量全转录组关联分析(TWAS)应用于六种 COPCs 的现有 GWAS 输出,以寻找与非痉挛性疼痛相关的遗传变异,然后进行遗传相关性(连锁-失衡分数回归)、基因组和组织富集分析。我们发现 24 个独立的单核苷酸多态性(SNPs)和 127 个独特的基因与非结节性疼痛显著相关,并显示非结节性疼痛是一种多基因性状,具有显著的 SNP 遗传性。我们发现多部位慢性疼痛和非痉挛性疼痛之间存在明显的遗传重叠,与类风湿性关节炎和神经病理性疼痛表型之间也存在较小程度的遗传重叠。组织富集分析强调了心脏和甲状腺组织,基因组富集分析强调了认知、人格和代谢特征与非可塑性疼痛的潜在共同机制,以及偏头痛和头痛的不同病理机制。我们利用现有的 COPC GWAS 输出结果,采用了一种强效网络方法来研究非痉挛性疼痛,结果表明非痉挛性疼痛是一种复杂的遗传性状,此外还有助于了解非痉挛性疼痛的潜在发展机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
HGG Advances
HGG Advances Biochemistry, Genetics and Molecular Biology-Molecular Medicine
CiteScore
4.30
自引率
4.50%
发文量
69
审稿时长
14 weeks
期刊最新文献
Chronic Overlapping Pain Conditions and Nociplastic Pain. Expanding the phenotypic spectrum of CSNK2A1-associated Okur-Chung neurodevelopmental syndrome. CUL3-Related Neurodevelopmental Disorder: Clinical Phenotype of 20 New Individuals and Identification of a Potential Phenotype-Associated Episignature. Letter to the Editor: Lack of association between classical HLA genes and asymptomatic SARS-CoV-2 infection. Epileptic encephalopathy linked to a DALRD3 missense variant that impairs tRNA modification.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1