The association of higher offspring early-childhood weight gain with prepregnancy metabolic and bariatric surgery

IF 4.2 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Obesity Pub Date : 2024-11-05 DOI:10.1002/oby.24166
Maya-Jean Hilaire, Annelise Babcock, Glenn White, Cynthia F. Masson, Rany M. Salem, Uma M. Reddy, Dympna Gallagher, Charles A. LeDuc, Vidhu V. Thaker
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Abstract

Objective

The objective of this study was to assess maternal gestational outcomes and offspring growth trajectories following prepregnancy metabolic and bariatric surgery (MBS) compared with non-MBS controls.

Methods

Single-center deliveries between January 2020 and March 2023 with prepregnancy Roux-en-Y gastric bypass (herein referred to as “bypass”), sleeve gastrectomy (herein referred to as “sleeve”), and non-MBS controls were included. Offspring growth trajectories were compared with the World Health Organization child growth standards. Linear mixed models assessed MBS-bypass and MBS-sleeve offspring weight, length, and BMI trajectories with a prepregnancy BMI 27 to 37 kg/m2 and propensity score-matched controls.

Results

The study included 440 participants with prepregnancy MBS (MBS-bypass, 185; MBS-sleeve, 225; 76% Hispanic/Latino) and 13,434 non-MBS controls. Gestational weight gain and gestational diabetes mellitus were similar, whereas hypertensive disorders of pregnancy were more common after MBS. The post-MBS offspring had lower birth weight but higher weight gain at 24 months (sleeve, +1.4 kg [95% CI: 1.0–1.9]; bypass, +0.5–0.7 kg [95% CI: 0.0–1.2]) compared with non-MBS groups. Male children had higher weight gain than females. The post-MBS-sleeve but not the post-MBS-bypass offspring had higher BMI z scores.

Conclusions

The higher early-life weight gain and sex differences in the post-MBS-sleeve group compared with the post-MBS-bypass group provide a window toward elucidating pathways to mitigate intergenerational metabolic risk transfer.

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后代幼儿期体重增加较多与孕前代谢和减肥手术有关。
研究目的本研究的目的是评估孕前代谢和减肥手术(MBS)与非MBS对照组相比的母体妊娠结局和后代生长轨迹:方法:纳入 2020 年 1 月至 2023 年 3 月期间单中心分娩的妊娠前 Roux-en-Y 胃旁路术(以下简称 "旁路术")、袖状胃切除术(以下简称 "袖状胃切除术")产妇和非 MBS 对照组。后代的生长轨迹与世界卫生组织的儿童生长标准进行了比较。线性混合模型评估了多囊卵巢旁路术和多囊卵巢袖状胃切除术后代的体重、身长和体重指数轨迹(孕前体重指数为 27 至 37 kg/m2 )以及倾向得分匹配对照组:该研究包括 440 名孕前多囊卵巢综合征患者(多囊卵巢综合征分流术,185 人;多囊卵巢综合征袖套术,225 人;76% 为西班牙裔/拉丁裔)和 13,434 名非多囊卵巢综合征对照组。妊娠体重增加和妊娠糖尿病的情况相似,而妊娠高血压疾病在 MBS 后更为常见。与非多囊卵巢综合征组相比,多囊卵巢综合征后的后代出生体重较低,但在 24 个月时体重增加较多(袖套,+1.4 千克 [95% CI:1.0-1.9];旁路,+0.5-0.7 千克 [95% CI:0.0-1.2])。男性儿童的体重增长高于女性。MBS套管术后而非MBS分流术后的后代BMI z评分更高:结论:与MBS分流术后组相比,MBS套管术后组早期体重增加较快,且存在性别差异,这为阐明减轻代际代谢风险转移的途径提供了一个窗口。
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来源期刊
Obesity
Obesity 医学-内分泌学与代谢
CiteScore
11.70
自引率
1.40%
发文量
261
审稿时长
2-4 weeks
期刊介绍: Obesity is the official journal of The Obesity Society and is the premier source of information for increasing knowledge, fostering translational research from basic to population science, and promoting better treatment for people with obesity. Obesity publishes important peer-reviewed research and cutting-edge reviews, commentaries, and public health and medical developments.
期刊最新文献
Issue Information Cardiometabolic characteristics of weight cycling: results from a mid-South regional comprehensive health care system Early changes in the gut microbiota are associated with weight outcomes over 2 years following metabolic and bariatric surgery In silico and functional analysis identifies key gene networks and novel gene candidates in obesity-linked human visceral fat Machine learning-based clustering identifies obesity subgroups with differential multi-omics profiles and metabolic patterns
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