Medial orbitofrontal cortex structure, function, and cognition associates with weight loss for laparoscopic sleeve gastrectomy

IF 4.9 2区医学 Q1 ENDOCRINOLOGY & METABOLISM Obesity Pub Date : 2025-01-28 DOI:10.1002/oby.24207

Xin Li, Wen Zhang, Yan Bi, Yanjie Duan, Xitai Sun, Jiu Chen, Xin Zhang, Zhou Zhang, Zhengyang Zhu, Bing Zhang

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Abstract

Objective

The objective of this study was to investigate underlying mechanisms of long-term effective weight loss after laparoscopic sleeve gastrectomy (LSG) and effects on the medial orbitofrontal cortex (mOFC) and cognition.

Methods

A total of 18 individuals with obesity (BMI ≥ 30 kg/m²) underwent LSG. Clinical data, cognitive scores, and brain magnetic resonance imaging scans were evaluated before LSG and 12 months after LSG. We employed voxel-based morphometry analysis and seed-based resting-state functional connectivity (RSFC) analysis to assess LSG-induced structural and functional changes in mOFC. Partial correlation analysis and univariate and multivariate linear regression models were used to explore associations among biochemical indexes, neuroimaging, cognition, and weight loss.

Results

No significant improvement in general cognition was found after LSG. Decreases in gray matter volume of the bilateral mOFC and increases in RSFC of the right mOFC were observed 12 months after LSG. Weight loss was associated with RSFC, general cognitive scores, and triglyceride changes. Multivariate linear regression model revealed gray matter volume of the left mOFC and working memory scores at baseline explained 55.2% of the variation in weight loss.

Conclusions

These findings suggest that mOFC imaging and cognitive scores could serve as biomarkers for predicting persistent weight loss after LSG, which provides a solid foundation for a potential target for neuromodulation research.

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内侧眼窝额叶皮层结构、功能和认知与腹腔镜袖胃切除术后体重减轻有关。

目的：探讨腹腔镜袖胃切除术（LSG）后长期有效减肥的潜在机制及其对内侧眶额皮质（mOFC）和认知功能的影响。方法：18例肥胖（BMI≥30 kg/m2）患者行LSG。临床资料、认知评分和脑磁共振成像扫描在LSG前和LSG后12个月进行评估。我们采用基于体素的形态学分析和基于种子的静息状态功能连接（RSFC）分析来评估lsg诱导的mOFC结构和功能变化。采用偏相关分析、单因素和多因素线性回归模型探讨生化指标、神经影像学、认知和体重减轻之间的关系。结果：LSG治疗后一般认知功能无明显改善。LSG 12个月后，观察到双侧mOFC灰质体积减少，右侧mOFC RSFC增加。体重减轻与RSFC、一般认知评分和甘油三酯变化有关。多元线性回归模型显示，左脑皮层灰质体积和基线工作记忆分数解释了55.2%的体重减轻变化。结论：这些发现提示mOFC成像和认知评分可以作为预测LSG后持续体重下降的生物标志物，为神经调节研究的潜在靶点提供了坚实的基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Obesity 医学-内分泌学与代谢

CiteScore

11.70

自引率

1.40%

发文量

261

审稿时长

2-4 weeks

期刊介绍： Obesity is the official journal of The Obesity Society and is the premier source of information for increasing knowledge, fostering translational research from basic to population science, and promoting better treatment for people with obesity. Obesity publishes important peer-reviewed research and cutting-edge reviews, commentaries, and public health and medical developments.