Recent advancements in selenium nanoconstructs as a potential carrier in cancer therapy

IF 5.45 Q1 Physics and Astronomy Nano-Structures & Nano-Objects Pub Date : 2024-11-04 DOI:10.1016/j.nanoso.2024.101399
Ritu Kudarha , Viola Colaco , Ashutosh Gupta , Sanjay Kulkarni , Soji Soman , Jahnavi Kulkarni , Komal Rana , Prerana Navti , Ruchi Tiwari , Riyaz Osmani , Deepanjan Datta , Mohit Angolkar , Srinivas Mutalik , Sudheer Moorkoth , Jayvadan Patel , Namdev Dhas
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Abstract

Cancer cells require energy to carry out essential tasks, grow, and survive, like all other body cells. The pathophysiological process of cancer is a complex one. The cytotoxicity, lack of selectivity, generation of multidrug resistance, and proliferation of stem-like cells are some of the issues facing current chemotherapy. To this end, nanoconstructs with unique inherent properties, including optical, magnetic, and electrical, with a desired nano range (<100 nm), have shown remarkable applications. There are numerous significant categories into which nanomaterials employed in cancer therapy can be divided. These nanomaterials, which target the immune system, tumour microenvironment, and cancer cells, have been modified for various cancer therapies to improve drug capacity and bioavailability, reduce toxicity, and improve specificity. The distinct bioactivities of inorganic metallic NPs include silver (Ag), gold (Au), cerium (Ce), iron (Fe), selenium (Se), titanium (Ti), platinum (Pt) and zinc (Zn), giving them a prominent position among other NPs. Selenium nanoparticles (SeNPs), particularly, have garnered attention due to their unique pharmacological properties. As an essential trace element, Se forms the active site in selenoproteins like selenocysteine (Sec), which regulates the physiological redox balance through its oxidoreductase activity. SeNPs have emerged as promising therapeutic agents in recent decades due to their reduced toxicity compared to Se, which has a narrow therapeutic window. SeNPs also exhibit synergistic effects with the therapeutic cargo, enhancing the anticancer activity. In this review, we have discussed the pharmacological effects of SeNPs, their pharmacological protective role against inflammation and oxidative stress-mediated conditions, and the latest advances in their synthesis and functionalization, utilized in cancer medication delivery systems, targeted drug delivery systems and gene delivery systems. In addition, we present an update on the most recent reported preclinical research involving the utilization of SeNPs in cancer treatment.
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硒纳米结构作为癌症治疗潜在载体的最新进展
癌细胞与人体其他细胞一样,需要能量来完成基本任务、生长和存活。癌症的病理生理过程十分复杂。细胞毒性、缺乏选择性、多药耐药性的产生以及类干细胞的增殖是当前化疗面临的一些问题。为此,具有独特固有特性(包括光学、磁学和电学)、理想纳米范围(100 纳米)的纳米结构已显示出显著的应用前景。用于癌症治疗的纳米材料可分为许多重要类别。这些以免疫系统、肿瘤微环境和癌细胞为靶点的纳米材料已在各种癌症疗法中得到改良,以提高药物容量和生物利用度、降低毒性和提高特异性。银(Ag)、金(Au)、铈(Ce)、铁(Fe)、硒(Se)、钛(Ti)、铂(Pt)和锌(Zn)等无机金属纳米粒子具有独特的生物活性,因此在其他纳米粒子中占有突出地位。尤其是硒纳米粒子(SeNPs),因其独特的药理特性而备受关注。作为一种重要的微量元素,硒在硒半胱氨酸(Sec)等硒蛋白中形成活性位点,通过其氧化还原酶活性调节生理氧化还原平衡。与治疗窗口较窄的硒相比,SeNPs 的毒性更低,因此近几十年来,SeNPs 已成为很有前景的治疗药物。SeNPs 还能与治疗药物产生协同效应,增强抗癌活性。在这篇综述中,我们讨论了 SeNPs 的药理作用、其对炎症和氧化应激介导的病症的药理保护作用,以及其合成和功能化的最新进展,并将其用于癌症药物输送系统、靶向药物输送系统和基因输送系统。此外,我们还介绍了有关利用 SeNPs 治疗癌症的最新临床前研究报告。
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来源期刊
Nano-Structures & Nano-Objects
Nano-Structures & Nano-Objects Physics and Astronomy-Condensed Matter Physics
CiteScore
9.20
自引率
0.00%
发文量
60
审稿时长
22 days
期刊介绍: Nano-Structures & Nano-Objects is a new journal devoted to all aspects of the synthesis and the properties of this new flourishing domain. The journal is devoted to novel architectures at the nano-level with an emphasis on new synthesis and characterization methods. The journal is focused on the objects rather than on their applications. However, the research for new applications of original nano-structures & nano-objects in various fields such as nano-electronics, energy conversion, catalysis, drug delivery and nano-medicine is also welcome. The scope of Nano-Structures & Nano-Objects involves: -Metal and alloy nanoparticles with complex nanostructures such as shape control, core-shell and dumbells -Oxide nanoparticles and nanostructures, with complex oxide/metal, oxide/surface and oxide /organic interfaces -Inorganic semi-conducting nanoparticles (quantum dots) with an emphasis on new phases, structures, shapes and complexity -Nanostructures involving molecular inorganic species such as nanoparticles of coordination compounds, molecular magnets, spin transition nanoparticles etc. or organic nano-objects, in particular for molecular electronics -Nanostructured materials such as nano-MOFs and nano-zeolites -Hetero-junctions between molecules and nano-objects, between different nano-objects & nanostructures or between nano-objects & nanostructures and surfaces -Methods of characterization specific of the nano size or adapted for the nano size such as X-ray and neutron scattering, light scattering, NMR, Raman, Plasmonics, near field microscopies, various TEM and SEM techniques, magnetic studies, etc .
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