Modulatory effects of inorganic mercury (Hg (II)) and lead (Pb (II)) on immune responses of Pekin ducklings (Anas platyrhynchos domesticus) upon a viral-like immune challenge

IF 6.2 2区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES Ecotoxicology and Environmental Safety Pub Date : 2024-11-04 DOI:10.1016/j.ecoenv.2024.117267
Biyao Han , Alan Kroeze , Hans van den Berg , Ivo Roessink , Nico W. van den Brink
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Abstract

Trace metal contamination is ubiquitous around the world and may affect the health of wildlife. Divalent trace metals, including ions of mercury (Hg) and lead (Pb), have been shown to be immunotoxic to avian species. However, little is known about the immunomodulatory effects of trace metal exposure on viral infections, especially in young birds, who may be more sensitive. Therefore, the objective of the current study is to provide more insights in the causality between trace metal exposure and the effects of exposure on the immune responses in young waterfowls. Pekin duckling was used as an animal model to investigate the effects of inorganic divalent Hg (II) and Pb (II) on avian immune responses upon a viral-like challenge with double-stranded RNA. Our results indicate that Hg (II) altered the immune gene expression 24 h post-challenge, as reflected by induction of pro-inflammatory genes IL-8, iNOS, TLR3 and TLR7, and a significant decrease of microRNA-155. Ducklings exposed to Pb (II) showed lower levels of natural antibodies, reduced white blood cell counts and lower heterophil proportions 24 h post-challenge. Although inorganic divalent Hg (II) and Pb (II) showed specific differential effects on the immune response of Pekin ducklings, the overall adverse immunomodulatory outcomes in both cases point to inflammation, impaired B-cell function, and weaker immunocompetence.
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无机汞(Hg (II))和铅(Pb (II))对病毒样免疫挑战下北京鸭(Anas platyrhynchos domesticus)免疫反应的调节作用
痕量金属污染在世界各地无处不在,可能会影响野生动物的健康。二价痕量金属,包括汞(Hg)和铅(Pb)离子,已被证明对鸟类具有免疫毒性。然而,人们对接触微量金属对病毒感染的免疫调节作用知之甚少,尤其是对幼鸟可能更为敏感。因此,本研究的目的是进一步了解微量金属暴露与暴露对幼年水禽免疫反应的影响之间的因果关系。本研究以北京鸭为动物模型,研究无机二价汞(II)和铅(II)在双链 RNA 病毒样挑战下对禽类免疫反应的影响。结果表明,汞(II)改变了挑战后 24 小时的免疫基因表达,表现为诱导促炎基因 IL-8、iNOS、TLR3 和 TLR7,以及显著降低 microRNA-155。暴露于铅(II)的雏鸭在挑战后 24 小时内表现出较低的天然抗体水平、较低的白细胞计数和较低的异性嗜血杆菌比例。虽然无机二价汞(II)和铅(II)对雏鸭的免疫反应有不同的影响,但两者的总体不良免疫调节结果都指向炎症、B细胞功能受损和免疫能力减弱。
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来源期刊
CiteScore
12.10
自引率
5.90%
发文量
1234
审稿时长
88 days
期刊介绍: Ecotoxicology and Environmental Safety is a multi-disciplinary journal that focuses on understanding the exposure and effects of environmental contamination on organisms including human health. The scope of the journal covers three main themes. The topics within these themes, indicated below, include (but are not limited to) the following: Ecotoxicology、Environmental Chemistry、Environmental Safety etc.
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