Neuroprotective properties of zinc oxide nanoparticles: therapeutic implications for Parkinson's disease.

IF 3.8 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Bioscience Reports Pub Date : 2024-11-27 DOI:10.1042/BSR20241102
Kim San Tang, Wesley Zhi Chung See, Rakesh Naidu
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Abstract

Parkinson's disease (PD) significantly affects millions of people worldwide due to the progressive degeneration of dopamine-producing neurons in the substantia nigra pars compacta. Despite extensive research efforts, effective treatments that can halt or reverse the progression of PD remain elusive. In recent years, nanotechnology has emerged as a promising new avenue for addressing this challenge, with zinc oxide nanoparticles (ZnO-NPs) standing out for their extensive therapeutic potential. ZnO-NPs have shown remarkable promise in neuroprotection through several key mechanisms. The multifaceted properties of ZnO-NPs suggest that they could play a crucial role in intervening across various fundamental mechanisms implicated in PD. By targeting these mechanisms, ZnO-NPs offer new insights and potential strategies for managing and treating PD. This review aims to provide a thorough examination of the molecular mechanisms through which ZnO-NPs exert their neuroprotective effects. It highlights their potential as innovative therapeutic agents for PD and outlines directions for future research to explore and harness their full capabilities.

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纳米氧化锌的神经保护特性:对帕金森病的治疗意义。
帕金森病(Parkinson's disease,PD)严重影响着全球数百万人,其原因是黑质髓鞘中产生多巴胺的神经元逐渐退化。尽管开展了大量的研究工作,但能够阻止或逆转帕金森病进展的有效治疗方法仍然遥遥无期。近年来,纳米技术已成为应对这一挑战的前景广阔的新途径,其中氧化锌纳米粒子(ZnO-NPs)因其广泛的治疗潜力而脱颖而出。ZnO-NPs 通过几种关键机制在神经保护方面显示出显著的前景。ZnO-NPs 的多方面特性表明,它们可以在干预与帕金森病有关的各种基本机制方面发挥关键作用。通过针对这些机制,ZnO-NPs 为控制和治疗帕金森病提供了新的见解和潜在的策略。本综述旨在对 ZnO-NPs 发挥神经保护作用的分子机制进行深入研究。它强调了ZnO-NPs作为治疗帕金森病的创新药物的潜力,并概述了未来研究的方向,以探索和利用其全部功能。
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来源期刊
Bioscience Reports
Bioscience Reports 生物-细胞生物学
CiteScore
8.50
自引率
0.00%
发文量
380
审稿时长
6-12 weeks
期刊介绍: Bioscience Reports provides a home for sound scientific research in all areas of cell biology and molecular life sciences. Since 2012, Bioscience Reports has been fully Open Access and publishes all papers under the liberal CC BY licence, giving the life science community quality research to share and discuss.Content before 2012 is subscription-only, and is accessible via archive purchase. Articles are assessed on soundness, providing a home for valid findings and data. We welcome papers that span disciplines (e.g. chemistry, medicine), including papers describing: -new methodologies -tools and reagents to probe biological questions -mechanistic details -disease mechanisms -metabolic processes and their regulation -structure and function -bioenergetics
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