Intrinsic immunomodulatory hydrogels for chronic inflammation.

IF 40.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Chemical Society Reviews Pub Date : 2024-11-05 DOI:10.1039/d4cs00450g
Yuna Qian, Jiayi Ding, Rui Zhao, Yang Song, Jiyoung Yoo, Huiyeon Moon, Seyoung Koo, Jong Seung Kim, Jianliang Shen
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Abstract

The immune system plays a pivotal role in maintaining physiological homeostasis and influencing disease processes. Dysregulated immune responses drive chronic inflammation, which in turn results in a range of diseases that are among the leading causes of death globally. Traditional immune interventions, which aim to regulate either insufficient or excessive inflammation, frequently entail lifelong comorbidities and the risk of severe side effects. In this context, intrinsic immunomodulatory hydrogels, designed to precisely control the local immune microenvironment, have recently attracted increasing attention. In particular, these advanced hydrogels not only function as delivery mechanisms but also actively engage in immune modulation, optimizing interactions with the immune system for enhanced tissue repair, thereby providing a sophisticated strategy for managing chronic inflammation. In this tutorial review, we outline key elements of chronic inflammation and subsequently explore the strategic design principles of intrinsic immunomodulatory hydrogels based on these elements. Finally, we examine the challenges and prospects of such immunomodulatory hydrogels, which are expected to inspire further preclinical research and clinical translation in addressing chronic inflammation.

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用于慢性炎症的内在免疫调节水凝胶。
免疫系统在维持生理平衡和影响疾病进程方面发挥着举足轻重的作用。失调的免疫反应会导致慢性炎症,进而引发一系列疾病,这些疾病是全球死亡的主要原因之一。传统的免疫干预措施旨在调节不足或过度的炎症反应,但往往会带来终身的并发症和严重副作用的风险。在这种情况下,旨在精确控制局部免疫微环境的固有免疫调节水凝胶最近引起了越来越多的关注。特别是,这些先进的水凝胶不仅具有输送机制的功能,还能主动参与免疫调节,优化与免疫系统的相互作用以增强组织修复,从而为控制慢性炎症提供了一种先进的策略。在这篇教程综述中,我们概述了慢性炎症的关键因素,随后探讨了基于这些因素的内在免疫调节水凝胶的战略设计原则。最后,我们将探讨此类免疫调节水凝胶所面临的挑战和前景,预计它们将在应对慢性炎症方面激发进一步的临床前研究和临床转化。
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来源期刊
Chemical Society Reviews
Chemical Society Reviews 化学-化学综合
CiteScore
80.80
自引率
1.10%
发文量
345
审稿时长
6.0 months
期刊介绍: Chemical Society Reviews is published by: Royal Society of Chemistry. Focus: Review articles on topics of current interest in chemistry; Predecessors: Quarterly Reviews, Chemical Society (1947–1971); Current title: Since 1971; Impact factor: 60.615 (2021); Themed issues: Occasional themed issues on new and emerging areas of research in the chemical sciences
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