Quantity of delta-9-tetrahydrocannabinol consumption and cannabis use disorder among daily cannabis consumers.

IF 5.2 1区医学 Q1 PSYCHIATRY Addiction Pub Date : 2024-11-06 DOI:10.1111/add.16700

Jacob T Borodovsky, Deborah S Hasin, Melanie Wall, Cara A Struble, Mohammad I Habib, Ofir Livne, Jun Liu, Lynn Chen, Efrat Aharonovich, Alan J Budney

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Abstract

Background and aims: Amid escalating cannabis legalization and daily consumption in the United States (US), determining the risk of cannabis use disorder (CUD) and relevant consequences among daily consumers has become a public health priority. Understanding these risks requires valid assessment of the daily quantity of delta-9-tetrahydrocannabinol (THC) consumed and its relation to consequences. This study characterized daily cannabis consumption using a new method for estimating milligrams of THC (mgTHC), and examined the relationship between daily mgTHC and CUD severity in a large national sample of daily consumers.

Design, setting and participants: US adult (aged 18+ years) daily cannabis consumers (n = 4134) completed a comprehensive online survey of cannabis consumption patterns (e.g. frequency, quantity, product types, potencies, administration methods) and Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5) CUD criteria.

Measurements: The primary exposure was past-week daily mgTHC consumption, calculated from survey responses to queries about product type, amount and potency consumed and including adjustments for puff size and loss of THC from specific methods of administration. The primary outcomes were (1) number of CUD criteria (range = 0-11) and (2) CUD severity categories: none, mild, moderate, severe.

Findings: Median daily consumption was ~130 mgTHC, with substantial variability (25% ≤ 50 mg and 25% ≥ 290 mg). On average, participants endorsed 2.5 CUD criteria, and 65% met criteria for CUD (39% mild, 18% moderate, 8% severe). Greater daily mgTHC predicted higher CUD criteria count [beta_log(mgTHC) = 0.50, 95% confidence interval (CI) = 0.267-0.734] and higher odds of mild [log odds ratio (logOR) = 0.238, 95% CI = 0.184-0.292], moderate (logOR = 0.303, 95% CI = 0.232-0.374) or severe (logOR = 0.335, 95% CI = 0.236-0.435) CUD.

Conclusions: Among daily consumers of cannabis, there appears to be a positive relationship between the daily quantity of cannabis consumed (measured in milligrams of delta-9-tetrahydrocannabinol) and both the risk and severity of cannabis use disorder.

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每日吸食大麻者的δ-9-四氢大麻酚消费量和大麻使用障碍。

背景和目的：随着美国大麻合法化和日常消费的不断升级，确定日常消费人群中大麻使用障碍（CUD）的风险和相关后果已成为公共卫生的当务之急。要了解这些风险，就必须对每日消费的δ-9-四氢大麻酚（THC）数量及其与后果的关系进行有效评估。本研究使用一种估算四氢大麻酚毫克数（mgTHC）的新方法来描述每日大麻消费的特点，并在一个大型的全国每日消费样本中研究了每日毫克四氢大麻酚与 CUD 严重程度之间的关系：美国成人（18 岁以上）日常大麻消费者（n = 4134）完成了一项关于大麻消费模式（如频率、数量、产品类型、效力、给药方法）和《精神疾病诊断与统计手册》第五版（DSM-5）CUD 标准的全面在线调查：主要暴露量是过去一周的每日毫克四氢大麻酚消耗量，该消耗量是根据对产品类型、消耗量和效力询问的调查回答计算得出的，包括对粉扑大小和特定给药方法造成的四氢大麻酚损失进行的调整。主要结果是：（1）CUD 标准的数量（范围 = 0-11）；（2）CUD 严重程度分类：无、轻度、中度、重度：研究结果：每日消费的中位数为约 130 毫克四氢大麻酚，差异很大（25% ≤ 50 毫克，25% ≥ 290 毫克）。参与者平均认可 2.5 项 CUD 标准，65% 符合 CUD 标准（39% 轻度，18% 中度，8% 重度）。较高的每日 mgTHC 预测较高的 CUD 标准数[betalog（mgTHC）= 0.50，95% 置信区间（CI）= 0.267-0.734]和较高的轻度[对数概率（logOR）= 0.238，95% CI = 0.184-0.292]、中度（logOR = 0.303，95% CI = 0.232-0.374）或重度（logOR = 0.335，95% CI = 0.236-0.435）CUD：在每日吸食大麻的人群中，每日吸食大麻的数量（以δ-9-四氢大麻酚毫克为单位）与大麻使用障碍的风险和严重程度之间似乎存在正相关关系。

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来源期刊

Addiction 医学-精神病学

CiteScore

10.80

自引率

6.70%

发文量

319

审稿时长

3 months

期刊介绍： Addiction publishes peer-reviewed research reports on pharmacological and behavioural addictions, bringing together research conducted within many different disciplines. Its goal is to serve international and interdisciplinary scientific and clinical communication, to strengthen links between science and policy, and to stimulate and enhance the quality of debate. We seek submissions that are not only technically competent but are also original and contain information or ideas of fresh interest to our international readership. We seek to serve low- and middle-income (LAMI) countries as well as more economically developed countries. Addiction’s scope spans human experimental, epidemiological, social science, historical, clinical and policy research relating to addiction, primarily but not exclusively in the areas of psychoactive substance use and/or gambling. In addition to original research, the journal features editorials, commentaries, reviews, letters, and book reviews.