{"title":"Comparative analysis of Zero Pressure Geometry and prestress methods in cardiovascular Fluid-Structure Interaction","authors":"","doi":"10.1016/j.cmpb.2024.108475","DOIUrl":null,"url":null,"abstract":"<div><h3>Background and Objective:</h3><div>Modelling patient-specific aortic biomechanics with advanced computational techniques, such as Fluid–Structure Interaction (FSI), can be crucial to provide effective decision-making indices to enhance current clinical practices. To effectively simulate Ascending Thoracic Aortic Aneurysms (ATAA), the stress-free configuration must be defined. The Zero Pressure Geometry (ZPG) and the Prestress Tensor (PT) are two of the main approaches to tackle this issue. However, their impact on the numerical results is yet to be analysed. Computed Tomography Angiography (CTA) and Magnetic Resonance Imaging (MRI) data were used to develop patient-specific 2-way FSI frameworks.</div></div><div><h3>Methods:</h3><div>Three models were developed considering different tissue prestressing approaches to account for the reference configuration and their numerical results were compared. The selected approaches were: (i) ZPG, (ii) PT and (iii) a combination of the PT approach with a regional mapping of material properties (PTCAL).</div></div><div><h3>Results:</h3><div>The pressure fields estimated by all models were equivalent. The estimation of Wall Shear Stress (WSS) based metrics revealed good correspondence between all models except the Relative Residence Time (RRT). Regarding ATAA wall mechanics, the proposed extension to the PT approach presented a closer agreement with the ZPG model than its counterpart. Additionally, the PT and PTCAL approaches required around 60% fewer iterations to achieve cycle-to-cycle convergence than the ZPG algorithm.</div></div><div><h3>Conclusion:</h3><div>Using a regional mapping of material properties in combination with the PT method presented a better correspondence with the ZPG approach. The outcomes of this study can pave the way for advancing the accuracy and convergence of ATAA numerical models using the PT methodology.</div></div>","PeriodicalId":10624,"journal":{"name":"Computer methods and programs in biomedicine","volume":null,"pages":null},"PeriodicalIF":4.9000,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Computer methods and programs in biomedicine","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0169260724004681","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS","Score":null,"Total":0}
引用次数: 0
Abstract
Background and Objective:
Modelling patient-specific aortic biomechanics with advanced computational techniques, such as Fluid–Structure Interaction (FSI), can be crucial to provide effective decision-making indices to enhance current clinical practices. To effectively simulate Ascending Thoracic Aortic Aneurysms (ATAA), the stress-free configuration must be defined. The Zero Pressure Geometry (ZPG) and the Prestress Tensor (PT) are two of the main approaches to tackle this issue. However, their impact on the numerical results is yet to be analysed. Computed Tomography Angiography (CTA) and Magnetic Resonance Imaging (MRI) data were used to develop patient-specific 2-way FSI frameworks.
Methods:
Three models were developed considering different tissue prestressing approaches to account for the reference configuration and their numerical results were compared. The selected approaches were: (i) ZPG, (ii) PT and (iii) a combination of the PT approach with a regional mapping of material properties (PTCAL).
Results:
The pressure fields estimated by all models were equivalent. The estimation of Wall Shear Stress (WSS) based metrics revealed good correspondence between all models except the Relative Residence Time (RRT). Regarding ATAA wall mechanics, the proposed extension to the PT approach presented a closer agreement with the ZPG model than its counterpart. Additionally, the PT and PTCAL approaches required around 60% fewer iterations to achieve cycle-to-cycle convergence than the ZPG algorithm.
Conclusion:
Using a regional mapping of material properties in combination with the PT method presented a better correspondence with the ZPG approach. The outcomes of this study can pave the way for advancing the accuracy and convergence of ATAA numerical models using the PT methodology.
期刊介绍:
To encourage the development of formal computing methods, and their application in biomedical research and medical practice, by illustration of fundamental principles in biomedical informatics research; to stimulate basic research into application software design; to report the state of research of biomedical information processing projects; to report new computer methodologies applied in biomedical areas; the eventual distribution of demonstrable software to avoid duplication of effort; to provide a forum for discussion and improvement of existing software; to optimize contact between national organizations and regional user groups by promoting an international exchange of information on formal methods, standards and software in biomedicine.
Computer Methods and Programs in Biomedicine covers computing methodology and software systems derived from computing science for implementation in all aspects of biomedical research and medical practice. It is designed to serve: biochemists; biologists; geneticists; immunologists; neuroscientists; pharmacologists; toxicologists; clinicians; epidemiologists; psychiatrists; psychologists; cardiologists; chemists; (radio)physicists; computer scientists; programmers and systems analysts; biomedical, clinical, electrical and other engineers; teachers of medical informatics and users of educational software.