Nano-titanium coating on glass surface to improve platelet-rich fibrin (PRF) quality

IF 4.2 3区 医学 Q2 ENGINEERING, BIOMEDICAL Journal of Materials Science: Materials in Medicine Pub Date : 2024-11-06 DOI:10.1007/s10856-024-06838-3
Mustafa Tunalı, Esra Ercan, Suat Pat, Emrah Sarıca, Aysel Güven Bağla, Nilüfer Aytürk, Duygu Sıddıkoğlu, Vildan Bilgin
{"title":"Nano-titanium coating on glass surface to improve platelet-rich fibrin (PRF) quality","authors":"Mustafa Tunalı,&nbsp;Esra Ercan,&nbsp;Suat Pat,&nbsp;Emrah Sarıca,&nbsp;Aysel Güven Bağla,&nbsp;Nilüfer Aytürk,&nbsp;Duygu Sıddıkoğlu,&nbsp;Vildan Bilgin","doi":"10.1007/s10856-024-06838-3","DOIUrl":null,"url":null,"abstract":"<div><p>The quality of platelet-rich fibrin (PRF) is contingent on the surface characteristics interfacing with blood. Titanium’s superior platelet activation, surpassing silica, has made Titanium-platelet-rich fibrin (T-PRF) a favored autogenous bone graft material due to its extended degradation time. Pioneering a novel approach, this study aims to achieve an enhanced fibrin structure using glass tubes coated with nano-titanium, marking the surface’s debut in our PRF production endeavors. Employing a rapid thermionic vacuum arc (TVA) process under high vacuum, we conducted comprehensive analyses of the tubes. Comprehensive analyses, including X-ray diffraction (XRD), atomic force microscopy (AFM), scanning electron microscopy (SEM), and energy dispersive X-ray spectroscopy (EDS), were conducted on the nano-titanium-coated glass tubes. Three PRF types were formulated: silica-activated leukocyte- and platelet-rich fibrin (L-PRF, control group), machined-surface titanium tubes (T-PRF), and nano-titanium-coated tubes (nanoT-PRF). Analyses unveiled denser fibrin areas in nanoT-PRF than T-PRF, with the least dense areas in L-PRF. Cell distribution paralled between nanoT-PRF and T-PRF groups, while L-PRF cells were embedded in the fibrin border. NanoT-PRF exhibited the densest autogenous fibrin structure, suggesting prolonged in vivo resorption. Additionally, we explore the potential practicality of single-use production for nanoT-PRF tubes, introducing a promising clinical advancement. This study marks a significant stride in innovative biomaterial design, contributing to the progress of regenerative medicine.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":647,"journal":{"name":"Journal of Materials Science: Materials in Medicine","volume":"35 1","pages":""},"PeriodicalIF":4.2000,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10856-024-06838-3.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Materials Science: Materials in Medicine","FirstCategoryId":"5","ListUrlMain":"https://link.springer.com/article/10.1007/s10856-024-06838-3","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
引用次数: 0

Abstract

The quality of platelet-rich fibrin (PRF) is contingent on the surface characteristics interfacing with blood. Titanium’s superior platelet activation, surpassing silica, has made Titanium-platelet-rich fibrin (T-PRF) a favored autogenous bone graft material due to its extended degradation time. Pioneering a novel approach, this study aims to achieve an enhanced fibrin structure using glass tubes coated with nano-titanium, marking the surface’s debut in our PRF production endeavors. Employing a rapid thermionic vacuum arc (TVA) process under high vacuum, we conducted comprehensive analyses of the tubes. Comprehensive analyses, including X-ray diffraction (XRD), atomic force microscopy (AFM), scanning electron microscopy (SEM), and energy dispersive X-ray spectroscopy (EDS), were conducted on the nano-titanium-coated glass tubes. Three PRF types were formulated: silica-activated leukocyte- and platelet-rich fibrin (L-PRF, control group), machined-surface titanium tubes (T-PRF), and nano-titanium-coated tubes (nanoT-PRF). Analyses unveiled denser fibrin areas in nanoT-PRF than T-PRF, with the least dense areas in L-PRF. Cell distribution paralled between nanoT-PRF and T-PRF groups, while L-PRF cells were embedded in the fibrin border. NanoT-PRF exhibited the densest autogenous fibrin structure, suggesting prolonged in vivo resorption. Additionally, we explore the potential practicality of single-use production for nanoT-PRF tubes, introducing a promising clinical advancement. This study marks a significant stride in innovative biomaterial design, contributing to the progress of regenerative medicine.

Graphical Abstract

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
玻璃表面的纳米钛涂层可提高富血小板纤维蛋白(PRF)的质量。
富血小板纤维蛋白(PRF)的质量取决于与血液接触的表面特性。钛的血小板活化性能优越,超过了二氧化硅,因此钛富血小板纤维蛋白(T-PRF)的降解时间较长,是一种受青睐的自体骨移植材料。本研究开创了一种新方法,旨在使用涂有纳米钛的玻璃管实现增强的纤维蛋白结构,这标志着该表面首次出现在我们的富血小板纤维蛋白生产中。我们采用高真空下的快速热离子真空电弧(TVA)工艺,对玻璃管进行了全面分析。我们对纳米钛涂层玻璃管进行了全面分析,包括 X 射线衍射 (XRD)、原子力显微镜 (AFM)、扫描电子显微镜 (SEM) 和能量色散 X 射线光谱 (EDS)。共配制了三种 PRF:二氧化硅激活的富含白细胞和血小板的纤维蛋白(L-PRF,对照组)、机加工表面钛管(T-PRF)和纳米钛涂层管(nanoT-PRF)。分析结果显示,纳米钛管比钛管的纤维蛋白区域更密集,而 L-PRF 的纤维蛋白区域密度最低。细胞分布在 nanoT-PRF 组和 T-PRF 组之间,而 L-PRF 组细胞嵌入纤维蛋白边界。NanoT-PRF 表现出最致密的自体纤维蛋白结构,表明其在体内的吸收时间较长。此外,我们还探索了一次性生产纳米T-PRF管的潜在实用性,为临床应用带来了希望。这项研究标志着创新生物材料设计取得了重大进展,为再生医学的发展做出了贡献。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Journal of Materials Science: Materials in Medicine
Journal of Materials Science: Materials in Medicine 工程技术-材料科学:生物材料
CiteScore
8.00
自引率
0.00%
发文量
73
审稿时长
3.5 months
期刊介绍: The Journal of Materials Science: Materials in Medicine publishes refereed papers providing significant progress in the application of biomaterials and tissue engineering constructs as medical or dental implants, prostheses and devices. Coverage spans a wide range of topics from basic science to clinical applications, around the theme of materials in medicine and dentistry. The central element is the development of synthetic and natural materials used in orthopaedic, maxillofacial, cardiovascular, neurological, ophthalmic and dental applications. Special biomedical topics include biomaterial synthesis and characterisation, biocompatibility studies, nanomedicine, tissue engineering constructs and cell substrates, regenerative medicine, computer modelling and other advanced experimental methodologies.
期刊最新文献
Performance evaluation of a low-cost Ti-Mo-Fe (TMF8) as a replacement for Ti-6Al-4V for internal fixation implants used in mandibular angular fractures: a finite element analysis study Biocompatibility and antibacterial properties of medical stainless steel and titanium modified by alumina and hafnia films prepared by atomic layer deposition Nano-titanium coating on glass surface to improve platelet-rich fibrin (PRF) quality Enhancing osteogenesis and mandibular defect repair with magnesium-modified acellular bovine bone matrix Shear bond strength between dental adhesive systems and an experimental niobium-based implant material
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1