Paracetamol versus ibuprofen for early postpartum pain control: a randomized controlled trial.

IF 2.1 3区 医学 Q2 OBSTETRICS & GYNECOLOGY Archives of Gynecology and Obstetrics Pub Date : 2024-11-05 DOI:10.1007/s00404-024-07797-4
Shai Ram, Dotan Madar, Hila Shalev Ram, Goni Peleg, Yotam Lior, Ayelet Greenfeld, Gala Yakov, Yariv Yogev, Sharon Maslovitz
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Abstract

Introduction: To evaluate the effectiveness of paracetamol and ibuprofen as non-opioid treatments for postpartum pain control after vaginal delivery.

Materials and methods: This randomized controlled study at a university-affiliated medical center involved parturient who received blindly oral tablets of either 1000 mg of paracetamol or 400 mg of ibuprofen, post-vaginal birth. Pain levels were assessed using a numeric rating scale (NRS) at four time points: before treatment, and 1, 4, and 6 h post-treatment (T0, T1, T4, and T6, respectively). We also compared the need for additional analgesia, breastfeeding initiation, mobilization, and urination following the delivery between the groups. To ensure statistical power, the study was designed to detect differences of one point on the NRS with at least 37 women per group.

Results: A total of 107 women participated, including paracetamol (n = 52) and ibuprofen (n = 55) groups. Demographics and perinatal outcomes were similar across groups. No significant differences were found in the interval between delivery and request for pain control (8 ± 6-10.5 and 11 ± 6-16 h for the paracetamol and the ibuprofen, respectively, P = .13). Pain levels on the NRS were similar for both groups at all intervals. There were also no group differences in the time to the initiation of breastfeeding, mobilization, urination, or the need for additional analgesia.

Conclusion: Both, paracetamol and ibuprofen, can be considered equivalent and effective non-opioid alternatives for postpartum pain control. REGISTRY AT CLINICALTRIALS.GOV: (NCT04653506), https://register.

Clinicaltrials: gov/prs/beta/studies/S000AFOR00000066/recordSummary .

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对乙酰氨基酚与布洛芬用于产后早期疼痛控制:随机对照试验。
引言评估扑热息痛和布洛芬作为非阿片类药物治疗阴道分娩后产后疼痛控制的有效性:这项随机对照研究是在一所大学附属医疗中心进行的,产妇在阴道分娩后盲目口服 1000 毫克扑热息痛片剂或 400 毫克布洛芬片剂。在四个时间点(治疗前、治疗后 1、4 和 6 小时,分别为 T0、T1、T4 和 T6)使用数字评分量表 (NRS) 评估疼痛程度。我们还比较了两组产妇在分娩后对额外镇痛、母乳喂养、活动和排尿的需求。为确保统计能力,研究旨在检测每组至少 37 名产妇在 NRS 上一个点的差异:共有 107 名产妇参加,包括扑热息痛组(52 人)和布洛芬组(55 人)。各组的人口统计学和围产期结果相似。从分娩到要求止痛的时间间隔无明显差异(扑热息痛组和布洛芬组分别为 8 ± 6-10.5 小时和 11 ± 6-16 小时,P = .13)。在所有时间间隔内,两组的 NRS 疼痛水平相似。在开始母乳喂养、活动、排尿或需要额外镇痛的时间上也没有组间差异:结论:扑热息痛和布洛芬可被视为控制产后疼痛的同等有效的非阿片类替代药物。在 CLINICALTRIALS.GOV 注册:(NCT04653506),https://register.Clinicaltrials:gov/prs/beta/studies/S000AFOR00000066/recordSummary。
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来源期刊
CiteScore
4.70
自引率
15.40%
发文量
493
审稿时长
1 months
期刊介绍: Founded in 1870 as "Archiv für Gynaekologie", Archives of Gynecology and Obstetrics has a long and outstanding tradition. Since 1922 the journal has been the Organ of the Deutsche Gesellschaft für Gynäkologie und Geburtshilfe. "The Archives of Gynecology and Obstetrics" is circulated in over 40 countries world wide and is indexed in "PubMed/Medline" and "Science Citation Index Expanded/Journal Citation Report". The journal publishes invited and submitted reviews; peer-reviewed original articles about clinical topics and basic research as well as news and views and guidelines and position statements from all sub-specialties in gynecology and obstetrics.
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