SPLASH: Split-Body Randomized Clinical Trial of Poly-l-Lactic Acid for Adipogenesis and Volumization of the Hip Dell.

IF 2.5 3区医学 Q2 DERMATOLOGY Dermatologic Surgery Pub Date : 2024-11-06 DOI:10.1097/DSS.0000000000004417

Raheel Zubair, Lisa Ishii, Jameson Loyal, Nina Hartman, Sabrina G Fabi

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Abstract

Background: Injectable poly-l-lactic acid (PLLA-SCA) increases extracellular matrix to improve skin quality. The hip dell is an underappreciated element of gluteal aesthetics. Adipose tissue has roles in aesthetics and skin functioning.

Objective: To investigate the efficacy of PLLA-SCA treatment to induce adipogenesis and volumize the hip dell.

Materials and methods: This was a double-blinded, split-body trial of 15 women with hip dell volume deficits. Each subject was randomized to have 1 hip dell treated with 150 mg of PLLA-SCA while the contralateral hip dell received the equivalent volume of saline. Subjects received 3 treatments at 1-month intervals and were followed for 9 months. Assessments included physician global aesthetic improvement scale, ultrasonography, and histologic examination.

Results: Blinded investigators rated PLLA-SCA-treated hip dells as improved and much improved. The dermis and adipose layers increased in thickness by 26.1% and 27%. These measures, in addition to collagen and elastic fiber quality, were significantly improved compared with saline-treated hip dells, which did not change from baseline. Subject satisfaction was also significantly greater on the PLLA-SCA-treated side. No subject experienced significant adverse effects.

Conclusion: Poly-l-lactic acid is a safe and effective method for durable volumization and aesthetic improvement of the hip dell. PLLA-SCA may promote adipogenesis and elastogenesis.

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SPLASH：聚乳酸促进臀部德尔脂肪生成和体积增大的分体随机临床试验。

背景：注射用聚乳酸（PLLA-SCA）可增加细胞外基质，改善皮肤质量。臀部脂肪是臀部美学中一个不被重视的因素。脂肪组织在美学和皮肤功能方面发挥作用：研究 PLLA-SCA 治疗对诱导脂肪生成和丰满臀部的功效：这是一项双盲、分身试验，对 15 名髋关节体积不足的女性进行了研究。每名受试者被随机分配到一个髋臼，接受 150 毫克 PLLA-SCA 治疗，而对侧髋臼则接受等量的生理盐水治疗。受试者每隔 1 个月接受 3 次治疗，并随访 9 个月。评估包括医生整体美学改善量表、超声波检查和组织学检查：结果：盲法研究人员对经 PLLA-SCA 治疗的髋关节韧带的评分为 "改善 "和 "明显改善"。真皮层和脂肪层的厚度分别增加了 26.1% 和 27%。与生理盐水处理的髋关节相比，这些指标以及胶原蛋白和弹性纤维的质量都有显著改善，而生理盐水处理的髋关节与基线相比没有变化。受试者对 PLLA-SCA 治疗侧的满意度也明显提高。没有受试者出现明显的不良反应：结论：聚乳酸是一种安全有效的方法，能持久地丰满髋关节并改善其美观。PLLA-SCA可促进脂肪生成和弹性生成。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Dermatologic Surgery 医学-皮肤病学

CiteScore

3.10

自引率

16.70%

发文量

547

期刊介绍： Exclusively devoted to dermatologic surgery, the Dermatologic Surgery journal publishes the most clinically comprehensive and up-to-date information in its field. This unique monthly journal provides today’s most expansive and in-depth coverage of cosmetic and reconstructive skin surgery and skin cancer through peer-reviewed original articles, extensive illustrations, case reports, ongoing features, literature reviews and correspondence. The journal provides information on the latest scientific information for all types of dermatologic surgery including: -Ambulatory phlebectomy- Blepharoplasty- Body contouring- Chemical peels- Cryosurgery- Curettage and desiccation- Dermabrasion- Excision and closure- Flap Surgery- Grafting- Hair restoration surgery- Injectable neuromodulators- Laser surgery- Liposuction- Microdermabrasion- Microlipoinjection- Micropigmentation- Mohs micrographic surgery- Nail surgery- Phlebology- Sclerotherapy- Skin cancer surgery- Skin resurfacing- Soft-tissue fillers. Dermatologists, dermatologic surgeons, plastic surgeons, oculoplastic surgeons and facial plastic surgeons consider this a must-read publication for anyone in the field.