Shared genetic associations and etiology between obstructive sleep apnea and CVDs: A genome-wide cross-trait analysis and bidirectional Mendelian randomization analysis.
{"title":"Shared genetic associations and etiology between obstructive sleep apnea and CVDs: A genome-wide cross-trait analysis and bidirectional Mendelian randomization analysis.","authors":"Kun Feng, Jinyue Yang, Kai Liu","doi":"10.1093/eurjpc/zwae347","DOIUrl":null,"url":null,"abstract":"<p><strong>Aims: </strong>To investigate the genetic correlations and potential causal relationships between obstructive sleep apnea (OSA) and various cardiovascular diseases (CVDs), aiming to enhance understanding of shared genetic mechanisms and improve recognition and treatment of OSA in patients with CVDs.</p><p><strong>Methods: </strong>Utilizing genome-wide association study (GWAS) data, we analyzed shared genetics between OSA and CVDs using linkage disequilibrium score regression (LDSC), multi-trait analysis of GWAS (MTAG), and genotype-tissue expression analysis (GTEx TSEA). We further investigated causal relationships using Bayesian colocalization tests, bidirectional Mendelian randomization (MR), and latent causal variable (LCV) analysis.</p><p><strong>Results: </strong>We found strong associations between OSA and multiple CVDs: coronary artery disease (CAD), heart failure (HF), myocardial infarction (MI), stroke, and atrial fibrillation (AF). Novel SNPs related to CVDs were identified during single-trait MTAG analysis. By applying cross-trait MTAG, we identified 15 shared loci between OSA and CAD, 25 shared loci between OSA and MI, and 7 shared loci between OSA and HF. Shared genes are primarily expressed in the blood, heart, kidney, liver, muscle, and pancreas. MR analysis indicated a significant causal effect of OSA on HF and AF as a causal factor for OSA. LCV analysis suggested that AF was causally associated with OSA, while HF showed partial causality.</p><p><strong>Conclusions: </strong>Our study suggests strong genetic correlations between OSA and several CVDs. Further research is needed on the associations between OSA and CVDs, as well as the mechanisms of the identified loci.</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":null,"pages":null},"PeriodicalIF":8.4000,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"European journal of preventive cardiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/eurjpc/zwae347","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
引用次数: 0
Abstract
Aims: To investigate the genetic correlations and potential causal relationships between obstructive sleep apnea (OSA) and various cardiovascular diseases (CVDs), aiming to enhance understanding of shared genetic mechanisms and improve recognition and treatment of OSA in patients with CVDs.
Methods: Utilizing genome-wide association study (GWAS) data, we analyzed shared genetics between OSA and CVDs using linkage disequilibrium score regression (LDSC), multi-trait analysis of GWAS (MTAG), and genotype-tissue expression analysis (GTEx TSEA). We further investigated causal relationships using Bayesian colocalization tests, bidirectional Mendelian randomization (MR), and latent causal variable (LCV) analysis.
Results: We found strong associations between OSA and multiple CVDs: coronary artery disease (CAD), heart failure (HF), myocardial infarction (MI), stroke, and atrial fibrillation (AF). Novel SNPs related to CVDs were identified during single-trait MTAG analysis. By applying cross-trait MTAG, we identified 15 shared loci between OSA and CAD, 25 shared loci between OSA and MI, and 7 shared loci between OSA and HF. Shared genes are primarily expressed in the blood, heart, kidney, liver, muscle, and pancreas. MR analysis indicated a significant causal effect of OSA on HF and AF as a causal factor for OSA. LCV analysis suggested that AF was causally associated with OSA, while HF showed partial causality.
Conclusions: Our study suggests strong genetic correlations between OSA and several CVDs. Further research is needed on the associations between OSA and CVDs, as well as the mechanisms of the identified loci.
目的:研究阻塞性睡眠呼吸暂停(OSA)与各种心血管疾病(CVDs)之间的遗传相关性和潜在因果关系,旨在加深对共同遗传机制的理解,改善对心血管疾病患者OSA的识别和治疗:利用全基因组关联研究(GWAS)数据,我们使用关联不平衡评分回归(LDSC)、GWAS 多性状分析(MTAG)和基因型-组织表达分析(GTEx TSEA)分析了 OSA 和心血管疾病之间的共同遗传学机制。我们还使用贝叶斯共定位检验、双向孟德尔随机化(MR)和潜在因果变量(LCV)分析进一步研究了因果关系:结果:我们发现 OSA 与多种心血管疾病(冠状动脉疾病(CAD)、心力衰竭(HF)、心肌梗死(MI)、中风和心房颤动(AF))之间存在密切联系。在单性状 MTAG 分析中发现了与心血管疾病相关的新 SNPs。通过跨性状 MTAG 分析,我们在 OSA 和 CAD 之间发现了 15 个共享基因位点,在 OSA 和 MI 之间发现了 25 个共享基因位点,在 OSA 和 HF 之间发现了 7 个共享基因位点。共享基因主要在血液、心脏、肾脏、肝脏、肌肉和胰腺中表达。MR分析表明,OSA对HF有明显的因果效应,而房颤是OSA的一个因果因素。LCV分析表明,房颤与OSA存在因果关系,而高频则显示出部分因果关系:我们的研究表明,OSA 与多种心血管疾病之间存在密切的遗传相关性。结论:我们的研究表明,OSA 与几种心血管疾病之间存在很强的遗传相关性。对于 OSA 与心血管疾病之间的关联以及已确定基因位点的机制,还需要进一步研究。
期刊介绍:
European Journal of Preventive Cardiology (EJPC) is an official journal of the European Society of Cardiology (ESC) and the European Association of Preventive Cardiology (EAPC). The journal covers a wide range of scientific, clinical, and public health disciplines related to cardiovascular disease prevention, risk factor management, cardiovascular rehabilitation, population science and public health, and exercise physiology. The categories covered by the journal include classical risk factors and treatment, lifestyle risk factors, non-modifiable cardiovascular risk factors, cardiovascular conditions, concomitant pathological conditions, sport cardiology, diagnostic tests, care settings, epidemiology, pharmacology and pharmacotherapy, machine learning, and artificial intelligence.