Association of furosemide versus chlorothiazide exposures with serum sodium, potassium, and chloride among infants with bronchopulmonary dysplasia.

IF 2.4 3区医学 Q2 OBSTETRICS & GYNECOLOGY Journal of Perinatology Pub Date : 2024-11-05 DOI:10.1038/s41372-024-02159-z

Timothy D Nelin, Matthew Huber, Erik A Jensen, Sara B DeMauro, Heidi Morris, Scott A Lorch, Kathleen Gibbs, Stamatia Alexiou, Natalie Napolitano, Anna Bustin, Nicolas A Bamat

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Abstract

Objectives: To examine the association of novel furosemide versus thiazide diuretic exposure with changes in serum sodium, potassium, and chloride levels among infants with grade 2/3 bronchopulmonary dysplasia (BPD).

Study design: Retrospective cohort study of infants admitted to a level IV neonatal intensive care unit (NICU) with grade 2/3 BPD. We measured within-subject change in serum sodium, potassium, and chloride before and after diuretic initiation using multivariable regression to adjust for differences in dosing and clinical covariates.

Results: We identified 94 infants contributing 137 novel diuretic exposures. No significant difference was noted in the association between chlorothiazide versus furosemide and serum sodium, potassium, or chloride change in multivariable modeling.

Conclusions: Changes in serum electrolytes were similar for chlorothiazide and furosemide, questioning the perception that chlorothiazide leads to less electrolyte derangement among preterm infants with grade 2/3 BPD.

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呋塞米与氯噻嗪的接触与支气管肺发育不良婴儿血清钠、钾和氯化物的关系。

研究目的研究设计：研究设计：对入住四级新生儿重症监护病房（NICU）、患有 2/3 级支气管肺发育不良的婴儿进行回顾性队列研究。我们测量了开始使用利尿剂前后受试者血清钠、钾和氯化物的变化，并使用多变量回归调整了剂量和临床协变量的差异：结果：我们确定了 94 名婴儿的 137 次新利尿剂暴露。在多变量模型中，氯噻嗪和呋塞米与血清钠、钾或氯化物变化之间的关系没有明显差异：结论：氯噻嗪和呋塞米的血清电解质变化相似，这对认为氯噻嗪导致2/3级BPD早产儿电解质紊乱较少的观点提出了质疑。

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来源期刊

Journal of Perinatology 医学-妇产科学

CiteScore

5.40

自引率

6.90%

发文量

284

审稿时长

3-8 weeks

期刊介绍： The Journal of Perinatology provides members of the perinatal/neonatal healthcare team with original information pertinent to improving maternal/fetal and neonatal care. We publish peer-reviewed clinical research articles, state-of-the art reviews, comments, quality improvement reports, and letters to the editor. Articles published in the Journal of Perinatology embrace the full scope of the specialty, including clinical, professional, political, administrative and educational aspects. The Journal also explores legal and ethical issues, neonatal technology and product development. The Journal’s audience includes all those that participate in perinatal/neonatal care, including, but not limited to neonatologists, perinatologists, perinatal epidemiologists, pediatricians and pediatric subspecialists, surgeons, neonatal and perinatal nurses, respiratory therapists, pharmacists, social workers, dieticians, speech and hearing experts, other allied health professionals, as well as subspecialists who participate in patient care including radiologists, laboratory medicine and pathologists.