Global Leadership Initiative on Malnutrition criteria: Clinical benefits for patients with gastric cancer.

IF 2.1 4区 医学 Q3 NUTRITION & DIETETICS Nutrition in Clinical Practice Pub Date : 2024-11-05 DOI:10.1002/ncp.11224
Jingxian Zheng, Xiaojie Wang, Jiami Yu, Qiaoting Hu, Zhouwei Zhan, Sijing Zhou, Jingjie Xu, Qifei Li, Chunhua Song, Chang Wang, Qingchuan Zhao, Hongxia Xu, Hanping Shi, Zengqing Guo
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Abstract

Malnutrition is a prevalent condition among patients with gastric cancer and is associated with poor survival outcomes. This study aimed to evaluate the clinical utility of the Global Leadership Initiative on Malnutrition (GLIM) criteria in predicting survival among patients with gastric cancer. The multicenter retrospective cohort study (INSCOC study) included 1406 patients enrolled between December 2012 and April 2020, with follow-up data collected until June 2023. Various indices for muscle evaluation, such as calf circumference (CC) and body weight-standardized hand grip strength (HGS/W), were used to diagnose malnutrition. Kaplan-Meier curves were used to analyze the relationship between nutrition status, as defined by GLIM criteria, and survival outcomes in these patients. The analysis revealed that using CC or HGS/W as positive indicators of malnutrition effectively identified patients with survival-related malnutrition. The incidence of malnutrition was 54.5%, with patients' median overall survival times of 1169 days for stage I and 575 days for stage II cancer (P < 0.001). Malnutrition was identified as an independent risk factor for survival. Additionally, a nomogram developed through Cox regression analysis demonstrated precise predictive capability, incorporating factors such as tumor node metastasis staging, Karnofsky Performance Status Scale, direct bilirubin levels, and nutrition intervention. The study concludes that the GLIM criteria are effective in diagnosing malnutrition and predicting survival in patients with gastric cancer. Nutrition interventions significantly enhance survival outcomes, underscoring the importance of standardized nutrition treatments in improving patient prognosis.

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营养不良问题全球领导力倡议标准:胃癌患者的临床获益。
营养不良是胃癌患者中的一种常见病,与不良的生存预后有关。本研究旨在评估全球营养不良领导倡议(GLIM)标准在预测胃癌患者生存率方面的临床实用性。这项多中心回顾性队列研究(INSCOC研究)纳入了2012年12月至2020年4月期间入组的1406名患者,随访数据收集至2023年6月。研究采用了各种肌肉评估指标,如小腿围(CC)和体重标准化手握力(HGS/W),以诊断营养不良。卡普兰-梅耶曲线用于分析这些患者的营养状况(根据 GLIM 标准定义)与生存结果之间的关系。分析结果显示,将CC或HGS/W作为营养不良的阳性指标可有效识别出与生存相关的营养不良患者。营养不良发生率为 54.5%,I 期癌症患者的中位总生存时间为 1169 天,II 期癌症患者的中位总生存时间为 575 天(P
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来源期刊
CiteScore
6.00
自引率
9.70%
发文量
128
审稿时长
3 months
期刊介绍: NCP is a peer-reviewed, interdisciplinary publication that publishes articles about the scientific basis and clinical application of nutrition and nutrition support. NCP contains comprehensive reviews, clinical research, case observations, and other types of papers written by experts in the field of nutrition and health care practitioners involved in the delivery of specialized nutrition support. This journal is a member of the Committee on Publication Ethics (COPE).
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