Three-dimensional semiquantitative evaluation of reactive emphysema in magnesium implant models.

IF 1.7 4区医学 Q2 SURGERY Minimally Invasive Therapy & Allied Technologies Pub Date : 2024-11-05 DOI:10.1080/13645706.2024.2423250

Yoshinori Hayashi, Kazuki Odagiri, Yuji Ishii, Keiichi Yamamoto, Tsuyoshi Takahashi, Kotaro Yamashita, Takuro Saito, Koji Tanaka, Kazuyoshi Yamamoto, Tomoki Makino, Yukinori Kurokawa, Hidetoshi Eguchi, Yuichiro Doki, Kiyokazu Nakajima

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Abstract

Background: Magnesium alloys have great potentials as bioabsorbable implants, whereas the difficulty in evaluating hydrogen gas produced in the degradation process has hindered their research and development. In this study, we investigated the possibility of industrial microfocus X-ray computed tomography (micro-CT) for the precise evaluation of subcutaneous emphysematous changes in a rabbit implantation model.

Methods: Magnesium plates with/without porous venting were implanted under skin defects on the backs of rabbits. The graft sites were examined by industrial micro-CT after sacrificing. The captured images were reconstructed three-dimensionally for volumetric analyses. The tissues of the graft site were also examined in the traditional histological investigation.

Results: We were able to image and numerate the shape and volume of subcutaneous emphysema using industrial micro-CT. The volume of emphysema was suppressed by pores punched in samples, and this trend increased as the number of pores increased. In the traditional histological examination, inflammatory changes were observed, but the emphysema could not be measured quantitatively.

Conclusions: Industrial micro-CT imaging makes it possible to visualize and evaluate magnesium-induced subcutaneous emphysema in animal experiment. This cross-border technology has the potential to be widely applied to other life science fields.

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镁植入模型反应性气肿的三维半定量评估。

背景：镁合金作为生物可吸收植入物具有巨大潜力，但由于难以评估降解过程中产生的氢气，阻碍了其研究和开发。在这项研究中，我们探讨了工业微聚焦 X 射线计算机断层扫描（micro-CT）在兔子植入模型中精确评估皮下气肿变化的可能性：方法：将带/不带多孔通气孔的镁板植入兔子背部皮肤缺损处。牺牲后用工业显微 CT 对移植部位进行检查。捕获的图像经过三维重建后进行容积分析。同时还对移植部位的组织进行了传统的组织学检查：结果：我们利用工业微计算机断层扫描技术对皮下气肿的形状和体积进行了成像和计算。气肿的体积受到样本上打孔的抑制，随着打孔数量的增加，这一趋势也在加剧。在传统的组织学检查中，可以观察到炎症变化，但无法对肺气肿进行定量测量：结论：工业微计算机断层扫描成像技术使在动物实验中观察和评估镁诱导的皮下气肿成为可能。这一跨界技术有望广泛应用于其他生命科学领域。

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来源期刊

Minimally Invasive Therapy & Allied Technologies 医学-外科

CiteScore

3.80

自引率

5.90%

发文量

审稿时长

6-12 weeks

期刊介绍： Minimally Invasive Therapy and Allied Technologies (MITAT) is an international forum for endoscopic surgeons, interventional radiologists and industrial instrument manufacturers. It is the official journal of the Society for Medical Innovation and Technology (SMIT) whose membership includes representatives from a broad spectrum of medical specialities, instrument manufacturing and research. The journal brings the latest developments and innovations in minimally invasive therapy to its readers. What makes Minimally Invasive Therapy and Allied Technologies unique is that we publish one or two special issues each year, which are devoted to a specific theme. Key topics covered by the journal include: interventional radiology, endoscopic surgery, imaging technology, manipulators and robotics for surgery and education and training for MIS.