Histone Lysine Lactylation (Kla)-induced BCAM Promotes OSCC Progression and Cis-Platinum Resistance.

IF 2.9 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Oral diseases Pub Date : 2024-11-06 DOI:10.1111/odi.15179

Guangzhao Huang, Su Chen, Jialu He, Honglin Li, Zhongkai Ma, Grace Paka Lubamba, Lei Wang, Zhiyong Guo, Chunjie Li

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引用次数: 0

Abstract

Objective: Histone lysine lactylation (Kla) plays a vital role in cancer progression. However, the prognostic value of histone Kla in oral squamous cell carcinoma (OSCC) remains unclear.

Materials and methods: OSCC RNA expression data were obtained from the TCGA and GEO databases. We explored the prognostic value of histone Kla in OSCC via constructing a Cox model and determined the role of Kla in OSCC drug susceptibility and tumor microenvironment (TME). In addition, the biological roles of candidate biomarkers were identified.

Results: A total of 1223 Kla-specific genes were obtained, with 228 DEKlaGs in OSCC. GO and KEGG enrichment analyses suggested that DEKlaGs contributed to inflammatory and cancer progression. A Cox model in accordance with BCAM, CGNL1, DGKG, and OLR1 could predict OSCC patient prognosis accurately. Subsequently, Kla-induced prognostic genes were identified to play a crucial role in OSCC drug therapy and TME. Moreover, BCAM was identified as a biomarker that promoted OSCC invasion, angiogenesis, and chemotherapy resistance.

Conclusion: Kla was identified to be associated with OSCC prognosis, drug therapy, and TME. Histone Kla-induced BCAM was identified to play a crucial role during OSCC progression, suggesting that Kla is promising to be a novel therapeutic target for OSCC.

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组蛋白赖氨酸乳化（Kla）诱导的 BCAM 促进 OSCC 进展和顺铂抗性

目的：组蛋白赖氨酸乳化（Kla）在癌症进展中起着至关重要的作用。然而，组蛋白Kla在口腔鳞状细胞癌（OSCC）中的预后价值仍不明确：OSCC的RNA表达数据来自TCGA和GEO数据库。我们通过构建Cox模型探讨了组蛋白Kla在OSCC中的预后价值，并确定了Kla在OSCC药物敏感性和肿瘤微环境（TME）中的作用。此外，还确定了候选生物标志物的生物学作用：结果：共获得1223个Kla特异性基因，其中228个DEKlaGs存在于OSCC中。GO和KEGG富集分析表明，DEKlaGs有助于炎症和癌症进展。根据BCAM、CGNL1、DGKG和OLR1建立的Cox模型可以准确预测OSCC患者的预后。随后，Kla诱导的预后基因被确定在OSCC药物治疗和TME中发挥关键作用。此外，BCAM被鉴定为促进OSCC侵袭、血管生成和化疗耐药的生物标志物：结论：Kla被认为与OSCC的预后、药物治疗和TME有关。结论：研究发现，Kla与OSCC的预后、药物治疗和TME相关，组蛋白Kla诱导的BCAM在OSCC进展过程中发挥着关键作用，这表明Kla有望成为OSCC的新型治疗靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral diseases 医学-牙科与口腔外科

CiteScore

7.60

自引率

5.30%

发文量

325

审稿时长

4-8 weeks

期刊介绍： Oral Diseases is a multidisciplinary and international journal with a focus on head and neck disorders, edited by leaders in the field, Professor Giovanni Lodi (Editor-in-Chief, Milan, Italy), Professor Stefano Petti (Deputy Editor, Rome, Italy) and Associate Professor Gulshan Sunavala-Dossabhoy (Deputy Editor, Shreveport, LA, USA). The journal is pre-eminent in oral medicine. Oral Diseases specifically strives to link often-isolated areas of dentistry and medicine through broad-based scholarship that includes well-designed and controlled clinical research, analytical epidemiology, and the translation of basic science in pre-clinical studies. The journal typically publishes articles relevant to many related medical specialties including especially dermatology, gastroenterology, hematology, immunology, infectious diseases, neuropsychiatry, oncology and otolaryngology. The essential requirement is that all submitted research is hypothesis-driven, with significant positive and negative results both welcomed. Equal publication emphasis is placed on etiology, pathogenesis, diagnosis, prevention and treatment.