Targeted memory reactivation with sleep disruption does not weaken week-old memories.

IF 3.6 1区 心理学 Q1 EDUCATION & EDUCATIONAL RESEARCH npj Science of Learning Pub Date : 2024-11-05 DOI:10.1038/s41539-024-00276-0
Nathan W Whitmore, Erika M Yamazaki, Ken A Paller
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Abstract

When memories are reactivated during sleep, they are potentially transformed and strengthened. However, disturbed sleep may make this process ineffective. In a prior study, memories formed shortly before sleep were weakened by auditory stimulation when that stimulation provoked memory reactivation while also disrupting sleep - a procedure known as targeted memory reactivation with sleep disruption (TMR-SD). Here we used TMR-SD to test whether memory weakening occurs for less-fragile memories. Participants first learned locations of 74 objects on a monitor. One week later, TMR-SD auditory cues linked with 50% of the previously learned object locations were presented during sleep. Even though the cues disturbed sleep, memories were not weakened when reactivated in this way, compared to when not reactivated. Whereas memory storage is vulnerable to disruption shortly after learning, this new evidence supports the notion that memory storage gradually gains resistance to the harm caused by reactivation combined with sleep disruption.

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干扰睡眠的定向记忆再激活不会削弱一周前的记忆。
当记忆在睡眠中被重新激活时,它们有可能得到转化和强化。然而,睡眠紊乱可能会使这一过程失效。在之前的一项研究中,当听觉刺激在扰乱睡眠的同时引起记忆再激活时,睡眠前不久形成的记忆会被听觉刺激削弱--这一过程被称为睡眠扰乱下的定向记忆再激活(TMR-SD)。在这里,我们使用TMR-SD来测试记忆弱化是否发生在不太脆弱的记忆上。参与者首先在显示器上学习 74 个物体的位置。一周后,在睡眠中出现与之前学习过的50%物体位置相关联的TMR-SD听觉提示。尽管这些提示干扰了睡眠,但与未被重新激活的记忆相比,以这种方式重新激活的记忆并没有减弱。虽然记忆存储在学习后不久就容易受到干扰,但这一新证据支持了这样一种观点,即记忆存储会逐渐抵御重新激活和睡眠干扰所造成的伤害。
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来源期刊
CiteScore
5.40
自引率
7.10%
发文量
29
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