{"title":"A bio-feedback-mimicking electrode combining real-time monitoring and drug delivery.","authors":"Shuaiyin Liu, Tianqin Ning, Junlin Chen, Yanzhe Fu, Jiebo Li, Jinyu Li, Xufeng Niu, Yubo Fan","doi":"10.1016/j.xinn.2024.100705","DOIUrl":null,"url":null,"abstract":"<p><p>Effective disease management based on real-time physiological changes presents a significant clinical challenge. A flexible electrode system integrating diagnosis and treatment can overcome the uncertainties associated with treatment progress during localized interventions. In this study, we develop a system featuring a biomimetic feedback regulation mechanism for drug delivery and real-time monitoring. To prevent drug leakage, the system incorporates a magnesium (Mg) valve in the outer layer, ensuring zero leakage when drug release is not required. The middle layer contains a drug-laden poly(3,4-ethylenedioxythiophene) (PEDOT) sponge (P-sponge), which supplies the water to partially or fully activate the Mg valve under electrical stimulation and initiate drug release. Once the valve is fully opened, the exposed and expanded P-sponge electrode establishes excellent contact with various tissues, facilitating the collection of electrophysiological signals. Encapsulation with polylactic acid film ensures the system's flexibility and bioresorbability, thereby minimizing potential side effects on surrounding tissues. Animal experiments demonstrate the system's capability to mimic feedback modulation mechanisms, enabling real-time monitoring and timely drug administration. This integrated diagnosis and treatment system offers an effective solution for the emergency management of acute diseases in clinical settings.</p>","PeriodicalId":36121,"journal":{"name":"The Innovation","volume":null,"pages":null},"PeriodicalIF":33.2000,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11536068/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Innovation","FirstCategoryId":"95","ListUrlMain":"https://doi.org/10.1016/j.xinn.2024.100705","RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/11/4 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"MULTIDISCIPLINARY SCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
Effective disease management based on real-time physiological changes presents a significant clinical challenge. A flexible electrode system integrating diagnosis and treatment can overcome the uncertainties associated with treatment progress during localized interventions. In this study, we develop a system featuring a biomimetic feedback regulation mechanism for drug delivery and real-time monitoring. To prevent drug leakage, the system incorporates a magnesium (Mg) valve in the outer layer, ensuring zero leakage when drug release is not required. The middle layer contains a drug-laden poly(3,4-ethylenedioxythiophene) (PEDOT) sponge (P-sponge), which supplies the water to partially or fully activate the Mg valve under electrical stimulation and initiate drug release. Once the valve is fully opened, the exposed and expanded P-sponge electrode establishes excellent contact with various tissues, facilitating the collection of electrophysiological signals. Encapsulation with polylactic acid film ensures the system's flexibility and bioresorbability, thereby minimizing potential side effects on surrounding tissues. Animal experiments demonstrate the system's capability to mimic feedback modulation mechanisms, enabling real-time monitoring and timely drug administration. This integrated diagnosis and treatment system offers an effective solution for the emergency management of acute diseases in clinical settings.
期刊介绍:
The Innovation is an interdisciplinary journal that aims to promote scientific application. It publishes cutting-edge research and high-quality reviews in various scientific disciplines, including physics, chemistry, materials, nanotechnology, biology, translational medicine, geoscience, and engineering. The journal adheres to the peer review and publishing standards of Cell Press journals.
The Innovation is committed to serving scientists and the public. It aims to publish significant advances promptly and provides a transparent exchange platform. The journal also strives to efficiently promote the translation from scientific discovery to technological achievements and rapidly disseminate scientific findings worldwide.
Indexed in the following databases, The Innovation has visibility in Scopus, Directory of Open Access Journals (DOAJ), Web of Science, Emerging Sources Citation Index (ESCI), PubMed Central, Compendex (previously Ei index), INSPEC, and CABI A&I.