A bio-feedback-mimicking electrode combining real-time monitoring and drug delivery.

IF 33.2 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES The Innovation Pub Date : 2024-09-30 eCollection Date: 2024-11-04 DOI:10.1016/j.xinn.2024.100705
Shuaiyin Liu, Tianqin Ning, Junlin Chen, Yanzhe Fu, Jiebo Li, Jinyu Li, Xufeng Niu, Yubo Fan
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Abstract

Effective disease management based on real-time physiological changes presents a significant clinical challenge. A flexible electrode system integrating diagnosis and treatment can overcome the uncertainties associated with treatment progress during localized interventions. In this study, we develop a system featuring a biomimetic feedback regulation mechanism for drug delivery and real-time monitoring. To prevent drug leakage, the system incorporates a magnesium (Mg) valve in the outer layer, ensuring zero leakage when drug release is not required. The middle layer contains a drug-laden poly(3,4-ethylenedioxythiophene) (PEDOT) sponge (P-sponge), which supplies the water to partially or fully activate the Mg valve under electrical stimulation and initiate drug release. Once the valve is fully opened, the exposed and expanded P-sponge electrode establishes excellent contact with various tissues, facilitating the collection of electrophysiological signals. Encapsulation with polylactic acid film ensures the system's flexibility and bioresorbability, thereby minimizing potential side effects on surrounding tissues. Animal experiments demonstrate the system's capability to mimic feedback modulation mechanisms, enabling real-time monitoring and timely drug administration. This integrated diagnosis and treatment system offers an effective solution for the emergency management of acute diseases in clinical settings.

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集实时监测和药物输送于一体的生物反馈模拟电极。
基于实时生理变化的有效疾病管理是一项重大的临床挑战。集诊断和治疗于一体的灵活电极系统可以克服局部干预过程中与治疗进展相关的不确定性。在这项研究中,我们开发了一种具有仿生物反馈调节机制的系统,用于药物输送和实时监测。为防止药物泄漏,该系统在外层安装了一个镁(Mg)阀,确保在不需要释放药物时药物零泄漏。中间层包含含有药物的聚(3,4-亚乙二氧基噻吩)(PEDOT)海绵(P-sponge),在电刺激下,P-sponge 提供水以部分或完全激活镁阀,启动药物释放。一旦镁瓣膜完全打开,外露和膨胀的 P-海绵电极就会与各种组织建立良好的接触,促进电生理信号的收集。聚乳酸薄膜封装确保了系统的灵活性和生物可吸收性,从而最大限度地减少了对周围组织的潜在副作用。动物实验证明,该系统能够模拟反馈调制机制,实现实时监测和及时给药。这种集成诊断和治疗系统为临床环境中急性疾病的紧急处理提供了有效的解决方案。
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来源期刊
The Innovation
The Innovation MULTIDISCIPLINARY SCIENCES-
CiteScore
38.30
自引率
1.20%
发文量
134
审稿时长
6 weeks
期刊介绍: The Innovation is an interdisciplinary journal that aims to promote scientific application. It publishes cutting-edge research and high-quality reviews in various scientific disciplines, including physics, chemistry, materials, nanotechnology, biology, translational medicine, geoscience, and engineering. The journal adheres to the peer review and publishing standards of Cell Press journals. The Innovation is committed to serving scientists and the public. It aims to publish significant advances promptly and provides a transparent exchange platform. The journal also strives to efficiently promote the translation from scientific discovery to technological achievements and rapidly disseminate scientific findings worldwide. Indexed in the following databases, The Innovation has visibility in Scopus, Directory of Open Access Journals (DOAJ), Web of Science, Emerging Sources Citation Index (ESCI), PubMed Central, Compendex (previously Ei index), INSPEC, and CABI A&I.
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