The Innovation最新文献

In deep learning super-resolution microscopy, concerns exist about the generation of artifacts, and methods for artifact suppression are lacking. We developed a self-adaptive fine-tuning method that dynamically adjusts the parameters of the models to minimize the loss function, which includes direct quantification of artifacts from live-cell imaging. Integrating self-adaptive fine-tuning with super-resolution models enables significant artifact reduction in the visualization of nanoscale organelle interactions at high spatial-temporal resolution.

An unprecedented heatwave swept the globe in 2023, marking it one of the hottest years on record and raising concerns about its health impacts. However, a comprehensive assessment of the heatwave-related mortality and its attribution to human-induced climate change remains lacking. We aim to address this gap by analyzing high-resolution climate and mortality data from 2,013 locations across 67 countries/territories using a three-stage modeling approach. First, we estimated historical heatwave-mortality associations using a quasi-Poisson regression model with distributed lag structures, considering lag effects, seasonality, and within-week variations. Second, we pooled the estimates in meta-regression, accounting for spatial heterogeneity and potential changes in heatwave-mortality associations over time. Third, we predicted grid-specific (0.5 0.5) association in 2023 and calculated the heatwave-related excess deaths, death ratio, and death rate per million people. Attribution analysis was conducted by comparing heatwave-related mortality under factual and counterfactual climate scenarios. We estimated 178,486 excess deaths (95% empirical confidence interval [eCI], 159,892≥204,147) related to the 2023 heatwave, accounting for 0.73% of global deaths, corresponding to 23 deaths per million people. The highest mortality rates occurred in Southern (120, 95% eCI, 116≥126), Eastern (107, 95% eCI, 100≥114), and Western Europe (66, 95% eCI, 62≥70), where the excess death ratio was also higher. Notably, 54.29% (95% eCI, 45.71%≥61.36%) of the global heatwave-related deaths were attributable to human-induced climate change. These results underscore the urgent need for adaptive public health interventions and climate mitigation strategies to reduce future mortality burdens in the context of increasing global warming.

Since the 20th century, the global soybean trade has undergone major changes, shaped by rising demand, climate-related risks, and shifting international dynamics. Despite its global importance, important gaps remain in understanding the complex drivers and sustainability challenges of this transformation. This review synthesizes both direct and indirect forces reshaping trade flows, spanning market dynamics, supply chain logistics, policy shifts, and technological innovation. We examine how soybean trade expansion has impacted deforestation, inequality, and food security, and assess the responses of governments and companies to address these challenges. Finally, we provide a forward-looking perspective on the strategic pathways needed to ensure a more resilient and sustainable global soybean system. The integrated insights offered in this review can inform sustainable trade strategies and foster cross-scale policy coordination for a more resilient global agri-food system.