Enabling Demonstrated Consent for Biobanking with Blockchain and Generative AI.

IF 17 1区 哲学 Q1 ETHICS American Journal of Bioethics Pub Date : 2024-11-05 DOI:10.1080/15265161.2024.2416117
Caspar Barnes, Mateo Riobo Aboy, Timo Minssen, Jemima Winifred Allen, Brian D Earp, Julian Savulescu, Sebastian Porsdam Mann
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Abstract

Participation in research is supposed to be voluntary and informed. Yet it is difficult to ensure people are adequately informed about the potential uses of their biological materials when they donate samples for future research. We propose a novel consent framework which we call "demonstrated consent" that leverages blockchain technology and generative AI to address this problem. In a demonstrated consent model, each donated sample is associated with a unique non-fungible token (NFT) on a blockchain, which records in its metadata information about the planned and past uses of the sample in research, and is updated with each use of the sample. This information is accessible to a large language model (LLM) customized to present this information in an understandable and interactive manner. Thus, our model uses blockchain and generative AI technologies to track, make available, and explain information regarding planned and past uses of donated samples.

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利用区块链和生成式人工智能实现生物银行的示范同意。
参与研究应该是自愿和知情的。然而,要确保人们在为未来研究捐赠样本时充分了解其生物材料的潜在用途却很困难。我们提出了一个新颖的同意框架,我们称之为 "展示同意",它利用区块链技术和生成式人工智能来解决这个问题。在 "证明同意 "模型中,每个捐赠样本都与区块链上唯一的不可篡改代币(NFT)相关联,该代币的元数据中记录了样本在研究中的计划用途和过去用途的信息,并随着样本的每次使用而更新。这些信息可通过定制的大型语言模型(LLM)获取,以可理解和交互的方式呈现这些信息。因此,我们的模型使用区块链和生成式人工智能技术来跟踪、提供和解释有关捐赠样本的计划用途和过去用途的信息。
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来源期刊
American Journal of Bioethics
American Journal of Bioethics 社会科学-科学史与科学哲学
CiteScore
12.30
自引率
26.90%
发文量
250
审稿时长
6-12 weeks
期刊介绍: The American Journal of Bioethics (AJOB) is a renowned global publication focused on bioethics. It tackles pressing ethical challenges in the realm of health sciences. With a commitment to the original vision of bioethics, AJOB explores the social consequences of advancements in biomedicine. It sparks meaningful discussions that have proved invaluable to a wide range of professionals, including judges, senators, journalists, scholars, and educators. AJOB covers various areas of interest, such as the ethical implications of clinical research, ensuring access to healthcare services, and the responsible handling of medical records and data. The journal welcomes contributions in the form of target articles presenting original research, open peer commentaries facilitating a dialogue, book reviews, and responses to open peer commentaries. By presenting insightful and authoritative content, AJOB continues to shape the field of bioethics and engage diverse stakeholders in crucial conversations about the intersection of medicine, ethics, and society.
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