Pub Date : 2025-03-18DOI: 10.1080/15265161.2025.2475015
Gabriel John Watts, Ainsley J Newson
Health Technology Assessment (HTA) has traditionally focused on efficacy, safety, and cost-effectiveness. There has long been concern, however, that this is determined by the goals of healthcare providers/payers, not patients. As a result, HTA arguably fails to reflect the overall value of health technologies-including their "non-clinical" or "personal" utility to patients and their families. The use of genomic testing in clinical care is one domain where this problem is evident, as the personal utility of results is often especially significant. As such, there are growing calls for HTA frameworks to adopt personal utility as a distinct element of value when assessing clinical genomic tests. We agree that personal utility is important to HTA in clinical genomics. However, against a trend toward comprehensive conceptions of personal utility within HTA, we advocate for a restrictive approach to assessing the value of personal utility in the case of clinical genomic testing.
{"title":"The Concept of Personal Utility in Genomic Testing: Three Ethical Tensions.","authors":"Gabriel John Watts, Ainsley J Newson","doi":"10.1080/15265161.2025.2475015","DOIUrl":"https://doi.org/10.1080/15265161.2025.2475015","url":null,"abstract":"<p><p>Health Technology Assessment (HTA) has traditionally focused on efficacy, safety, and cost-effectiveness. There has long been concern, however, that this is determined by the goals of healthcare providers/payers, not patients. As a result, HTA arguably fails to reflect the overall value of health technologies-including their \"non-clinical\" or \"personal\" utility to patients and their families. The use of genomic testing in clinical care is one domain where this problem is evident, as the personal utility of results is often especially significant. As such, there are growing calls for HTA frameworks to adopt personal utility as a distinct element of value when assessing clinical genomic tests. We agree that personal utility is important to HTA in clinical genomics. However, against a trend toward comprehensive conceptions of personal utility within HTA, we advocate for a restrictive approach to assessing the value of personal utility in the case of clinical genomic testing.</p>","PeriodicalId":50962,"journal":{"name":"American Journal of Bioethics","volume":" ","pages":"1-12"},"PeriodicalIF":17.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-12DOI: 10.1080/15265161.2025.2475025
Bryan Cwik
{"title":"Germline Genome Editing May Never Have Any Clinical Utility.","authors":"Bryan Cwik","doi":"10.1080/15265161.2025.2475025","DOIUrl":"https://doi.org/10.1080/15265161.2025.2475025","url":null,"abstract":"","PeriodicalId":50962,"journal":{"name":"American Journal of Bioethics","volume":" ","pages":"1-2"},"PeriodicalIF":17.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143607079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-11DOI: 10.1080/15265161.2025.2470680
Matthé Scholten, Esther Braun, Sarah Potthoff, Jakov Gather, Christin Hempeler
{"title":"Focusing on Service User Perspectives to Uncover the Boundary Between Treatment Pressure and Informal Coercion.","authors":"Matthé Scholten, Esther Braun, Sarah Potthoff, Jakov Gather, Christin Hempeler","doi":"10.1080/15265161.2025.2470680","DOIUrl":"https://doi.org/10.1080/15265161.2025.2470680","url":null,"abstract":"","PeriodicalId":50962,"journal":{"name":"American Journal of Bioethics","volume":" ","pages":"1-5"},"PeriodicalIF":17.0,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143607075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-11DOI: 10.1080/15265161.2025.2470696
Carolyn Riley Chapman, Patrick Dwyer, Kellie Owens, Courtney Berrios, Heini M Natri, Arthur L Caplan, Gwendolyn P Quinn
{"title":"Wanted, but Elusive: Clear Solutions for Addressing Potential Group Harm in Data-Centric Research.","authors":"Carolyn Riley Chapman, Patrick Dwyer, Kellie Owens, Courtney Berrios, Heini M Natri, Arthur L Caplan, Gwendolyn P Quinn","doi":"10.1080/15265161.2025.2470696","DOIUrl":"https://doi.org/10.1080/15265161.2025.2470696","url":null,"abstract":"","PeriodicalId":50962,"journal":{"name":"American Journal of Bioethics","volume":" ","pages":"1-4"},"PeriodicalIF":17.0,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143607043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-11DOI: 10.1080/15265161.2025.2470668
Ben Davies
{"title":"Mapping, Moralizing, and More: Response to Commentaries.","authors":"Ben Davies","doi":"10.1080/15265161.2025.2470668","DOIUrl":"https://doi.org/10.1080/15265161.2025.2470668","url":null,"abstract":"","PeriodicalId":50962,"journal":{"name":"American Journal of Bioethics","volume":" ","pages":"1-5"},"PeriodicalIF":17.0,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143607082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-11DOI: 10.1080/15265161.2025.2475014
Jason Adam Wasserman, Abram L Brummett, Mark Christopher Navin, Daniel Londyn Menkes
{"title":"The Proper Uses and Constraints on Exercises of Conscience in Cases of Profound Neurological Injury: A Dialogue with Our Colleagues.","authors":"Jason Adam Wasserman, Abram L Brummett, Mark Christopher Navin, Daniel Londyn Menkes","doi":"10.1080/15265161.2025.2475014","DOIUrl":"https://doi.org/10.1080/15265161.2025.2475014","url":null,"abstract":"","PeriodicalId":50962,"journal":{"name":"American Journal of Bioethics","volume":" ","pages":"1-5"},"PeriodicalIF":17.0,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143607040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-01Epub Date: 2025-02-24DOI: 10.1080/15265161.2025.2457720
Brian Michael Jackson
{"title":"Aligning Ongoing Care Teams and Proceduralists About Inappropriate Interventions Requires More Than Conscientious Objection.","authors":"Brian Michael Jackson","doi":"10.1080/15265161.2025.2457720","DOIUrl":"10.1080/15265161.2025.2457720","url":null,"abstract":"","PeriodicalId":50962,"journal":{"name":"American Journal of Bioethics","volume":"25 3","pages":"35-37"},"PeriodicalIF":17.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143494528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-01Epub Date: 2025-02-24DOI: 10.1080/15265161.2025.2457727
Rosamond Rhodes
{"title":"Conscientious Objection: A Morally Compromising and Needless Distraction in Medical Practice.","authors":"Rosamond Rhodes","doi":"10.1080/15265161.2025.2457727","DOIUrl":"10.1080/15265161.2025.2457727","url":null,"abstract":"","PeriodicalId":50962,"journal":{"name":"American Journal of Bioethics","volume":"25 3","pages":"22-25"},"PeriodicalIF":17.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143494572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-01Epub Date: 2025-02-24DOI: 10.1080/15265161.2025.2457700
Michael Pflanzer
{"title":"Balancing Transparency and Trust: Reevaluating AI Disclosure in Healthcare.","authors":"Michael Pflanzer","doi":"10.1080/15265161.2025.2457700","DOIUrl":"https://doi.org/10.1080/15265161.2025.2457700","url":null,"abstract":"","PeriodicalId":50962,"journal":{"name":"American Journal of Bioethics","volume":"25 3","pages":"153-156"},"PeriodicalIF":17.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143494474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-01Epub Date: 2025-02-24DOI: 10.1080/15265161.2025.2458425
Marka F Ellertson, Richard R Sharp
{"title":"Challenges in Pursuing AI Transparency.","authors":"Marka F Ellertson, Richard R Sharp","doi":"10.1080/15265161.2025.2458425","DOIUrl":"https://doi.org/10.1080/15265161.2025.2458425","url":null,"abstract":"","PeriodicalId":50962,"journal":{"name":"American Journal of Bioethics","volume":"25 3","pages":"4-6"},"PeriodicalIF":17.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143494489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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