Understanding Atopic Dermatitis in Asian and European Population Cohorts Using Complementary Omics Techniques.

Yik Weng Yew, Marie Loh, Sara J Brown
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Abstract

Atopic dermatitis is highly heterogeneous with respect to pathogenesis, clinical manifestations, and treatment response. There is evidence that ancestry and skin type each contribute to this heterogeneity, indicating the need to improve understanding of disease mechanisms in diverse populations. Methods to integrate multiomics studies have been well-described, but this review focuses on the importance and the strategies needed to integrate data across different ancestral groups, focusing, because of data availability, on Asian and European populations. Skin scientists and clinicians will each benefit from an understanding of how the multiple complimentary layers of omics data may inform future clinical management, from insight into disease pathogenesis and treatment targets.

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利用互补性 Omics 技术了解亚洲和欧洲人群队列中的特应性皮炎。
特应性皮炎在发病机制、临床表现和治疗反应方面具有高度异质性。有证据表明,祖先和皮肤类型都是造成这种异质性的原因,这表明有必要加深对不同人群疾病机理的了解。整合多组学研究的方法已经有了很好的描述,但本综述侧重于整合不同祖先群体数据的重要性和所需的策略,由于数据的可用性,重点是亚洲和欧洲人群。皮肤科学家和临床医生都将受益于对多层次互补的 omics 数据如何为未来临床管理提供信息的了解,包括对疾病发病机制和治疗目标的洞察。
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Disentangling Race from Skin Color in Modern Biology and Medicine. The Stephen Rothman Memorial Award 2024. Understanding Atopic Dermatitis in Asian and European Population Cohorts Using Complementary Omics Techniques. Emerging Techniques in Spatial Multiomics: Fundamental Principles and Applications to Dermatology. Anti-Laminin γ1 and β4 Antibodies in Anti-p200 Pemphigoid.
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