Heterogeneity and prognosis of single organ metastases in gastric cancer.

IF 3.8 Q2 GASTROENTEROLOGY & HEPATOLOGY Translational gastroenterology and hepatology Pub Date : 2024-09-25 eCollection Date: 2024-01-01 DOI:10.21037/tgh-24-11

Qian-Wen Zhao, Zheng Quan, Shan-Shan Liu, Yu-Dan Wang, Hao-Nan Guo

{"title":"Heterogeneity and prognosis of single organ metastases in gastric cancer.","authors":"Qian-Wen Zhao, Zheng Quan, Shan-Shan Liu, Yu-Dan Wang, Hao-Nan Guo","doi":"10.21037/tgh-24-11","DOIUrl":null,"url":null,"abstract":"Background: While single organ metastases generally present a more optimistic prognosis compared to multiple metastases, the influence of the specific organ site for single organ metastases on prognosis remains undetermined. This retrospective study aimed to investigate the prognostic differences in late-stage gastric cancer with single organ metastasis.Methods: Data for patients diagnosed with gastric cancer were retrieved from the Surveillance, Epidemiology, and End Results (SEER) database for survival analysis, covering years spanning from 2010 to 2016. Furthermore, Kaplan-Meier survival curves and Cox regression were utilized to analyze overall survival (OS) and disease-specific survival (DSS). Additionally, given the impact of confounders and bias on the results, prognosis was further analyzed using propensity score matching (PSM) and floating absolute risk methods.Results: A cohort comprising 4,297 patients diagnosed with gastric cancer and exhibiting single organ metastasis was hereby enrolled. Liver metastasis was the most common (71% of the total), while brain metastasis accounted for the least (1.7% of the total). Compared to other metastases, patients with bone metastasis presented the worst OS [hazard ratio (HR), 1.319; 95% confidence interval (CI): 1.207-1.442; P<0.001], and this remained consistent even upon the application of floating absolute risk (HR, 1.10; 95% CI: 1.01-1.20) and PSM methods (HR, 1.187; 95% CI: 1.053-1.339; P=0.005). In addition, subgroup analysis and interaction tests of OS revealed an interaction between age (P=0.02), histological type (P=0.002), and bone metastasis.Conclusions: In patients with single organ metastasis of gastric cancer, the prognosis varies by the metastatic site, with bone metastasis presenting the poorest outcome. Overall, this study forges a foundation for further research on the mechanisms and patterns of different metastatic sites in gastric cancer and informs treatment strategies.","PeriodicalId":94362,"journal":{"name":"Translational gastroenterology and hepatology","volume":"9 ","pages":"61"},"PeriodicalIF":3.8000,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11535815/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Translational gastroenterology and hepatology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.21037/tgh-24-11","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: While single organ metastases generally present a more optimistic prognosis compared to multiple metastases, the influence of the specific organ site for single organ metastases on prognosis remains undetermined. This retrospective study aimed to investigate the prognostic differences in late-stage gastric cancer with single organ metastasis.

Methods: Data for patients diagnosed with gastric cancer were retrieved from the Surveillance, Epidemiology, and End Results (SEER) database for survival analysis, covering years spanning from 2010 to 2016. Furthermore, Kaplan-Meier survival curves and Cox regression were utilized to analyze overall survival (OS) and disease-specific survival (DSS). Additionally, given the impact of confounders and bias on the results, prognosis was further analyzed using propensity score matching (PSM) and floating absolute risk methods.

Results: A cohort comprising 4,297 patients diagnosed with gastric cancer and exhibiting single organ metastasis was hereby enrolled. Liver metastasis was the most common (71% of the total), while brain metastasis accounted for the least (1.7% of the total). Compared to other metastases, patients with bone metastasis presented the worst OS [hazard ratio (HR), 1.319; 95% confidence interval (CI): 1.207-1.442; P<0.001], and this remained consistent even upon the application of floating absolute risk (HR, 1.10; 95% CI: 1.01-1.20) and PSM methods (HR, 1.187; 95% CI: 1.053-1.339; P=0.005). In addition, subgroup analysis and interaction tests of OS revealed an interaction between age (P=0.02), histological type (P=0.002), and bone metastasis.

Conclusions: In patients with single organ metastasis of gastric cancer, the prognosis varies by the metastatic site, with bone metastasis presenting the poorest outcome. Overall, this study forges a foundation for further research on the mechanisms and patterns of different metastatic sites in gastric cancer and informs treatment strategies.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

胃癌单器官转移的异质性和预后。

背景：与多发转移相比，单器官转移的预后通常更为乐观，但单器官转移的具体器官部位对预后的影响仍未确定。这项回顾性研究旨在探讨单器官转移的晚期胃癌预后差异：方法：从监测、流行病学和最终结果（SEER）数据库中获取被诊断为胃癌的患者数据进行生存分析，时间跨度为2010年至2016年。此外，还利用卡普兰-梅耶生存曲线和考克斯回归分析总生存期（OS）和疾病特异性生存期（DSS）。此外，考虑到混杂因素和偏倚对结果的影响，还采用倾向得分匹配（PSM）和浮动绝对风险法对预后进行了进一步分析：该研究共纳入了4297名确诊为胃癌并出现单器官转移的患者。肝转移最常见（占总数的 71%），脑转移最少（占总数的 1.7%）。与其他转移灶相比，骨转移患者的OS最差[危险比（HR），1.319；95%置信区间（CI）：1.207-1.442；PC结论：胃癌单器官转移患者的预后因转移部位而异，其中骨转移患者的预后最差。总之，这项研究为进一步研究胃癌不同转移部位的机制和模式奠定了基础，并为治疗策略提供了参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Translational gastroenterology and hepatology

自引率

0.00%

发文量