Catrin Lutz, Hendrik A Messal, Damir Vareslija, Stefan Prekovic
{"title":"The complex landscape of luminal breast cancer.","authors":"Catrin Lutz, Hendrik A Messal, Damir Vareslija, Stefan Prekovic","doi":"10.1530/ERC-24-0201","DOIUrl":null,"url":null,"abstract":"<p><p>The breast epithelium, vital for mammary gland function, is influenced by oestrogen through the oestrogen receptor (ER) signalling pathway. Luminal breast cancer (BC), characterised by ER expression, comprises the majority of all BCs and presents significant clinical challenges due to therapy resistance and recurrence. Despite advancements in understanding luminal disease, improving long-term survival and reducing relapse of BC patients by predicting therapy efficacy and understanding resistance mechanisms remain critical challenges. This review discusses luminal BC biology, focusing on the molecular classification of primary disease, metastatic spread, and experimental models.</p>","PeriodicalId":93989,"journal":{"name":"Endocrine-related cancer","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Endocrine-related cancer","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1530/ERC-24-0201","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"Print","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
The breast epithelium, vital for mammary gland function, is influenced by oestrogen through the oestrogen receptor (ER) signalling pathway. Luminal breast cancer (BC), characterised by ER expression, comprises the majority of all BCs and presents significant clinical challenges due to therapy resistance and recurrence. Despite advancements in understanding luminal disease, improving long-term survival and reducing relapse of BC patients by predicting therapy efficacy and understanding resistance mechanisms remain critical challenges. This review discusses luminal BC biology, focusing on the molecular classification of primary disease, metastatic spread, and experimental models.
乳腺上皮对乳腺功能至关重要,它通过 ER 信号通路受到雌激素的影响。以ER表达为特征的腔隙型乳腺癌占所有乳腺癌的大多数,由于耐药和复发,给临床带来了巨大挑战。尽管在了解腔隙性疾病方面取得了进展,但通过预测疗效和了解耐药机制来提高乳腺癌患者的长期生存率和减少复发仍然是严峻的挑战。本综述讨论腔隙性乳腺癌生物学,重点是原发疾病的分子分类、转移扩散和实验模型。