Tunable photoluminescence of electrosynthesized Ag2S@ZnSe quantum dots for nanomedicine applications

IF 5.45 Q1 Physics and Astronomy Nano-Structures & Nano-Objects Pub Date : 2024-11-05 DOI:10.1016/j.nanoso.2024.101400
{"title":"Tunable photoluminescence of electrosynthesized Ag2S@ZnSe quantum dots for nanomedicine applications","authors":"","doi":"10.1016/j.nanoso.2024.101400","DOIUrl":null,"url":null,"abstract":"<div><div>Quantum dots (QDs) synthesized from environmentally friendly precursors associated to scalable and high-efficiency production routes are essential for nanomedicine applications. Ag<sub>2</sub>S nanocrystal is notable by antimicrobial activity, photothermal properties, and low toxicity, making it promising bioactive nanomaterial. In this work, L-glutathione (GSH) capped Ag<sub>2</sub>S and ZnSe seeds were synthesized by using a fast and environmentally friendly electrochemical method (cavity cell, graphite powder macroelectrode and aqueous medium) and tested for biological applications. Ag<sub>2</sub>S nanocrystals presented a monoclinic structure (XRD analysis). The modulation of the optical properties was carried out by varying the Ag<sup>+</sup>/S<sup>2-</sup> ratio (1:1, 2:1, and 4:1), showing a photoluminescence hypsochromic shift from 916 to 759 nm, respectively. The modulation of the optical parameters was also carried out by the synthesis of Ag<sub>2</sub>S@ZnSe core/shell nanostructures. ZnSe seeds were prepared by the same electrochemical method and added to the Ag<sub>2</sub>S solution followed by thermal treatment under reflux (10 min). Ag<sub>2</sub>S@ZnSe systems showed higher photoluminescence intensity and a hypsochromic shift of the emission band using Ag<sub>2</sub>S cores (Ag<sup>+</sup>/S<sup>2-</sup> = 1:1 and 1:2), which was associated to the formation of alloy-type structures. In the case of the Ag<sub>2</sub>S@ZnSe (Ag<sup>+</sup>/S<sup>2-</sup> = 1:4), a bathochromic shift of the emission bands can be observed, which was associated to the formation of a core/shell structure. Ag<sub>2</sub>S@ZnSe QDs were tested in antimicrobial and cytotoxicity assays, showing a minimal inhibitory concentration (MIC) equal to 512 µg.mL<sup>−1</sup>. No cytotoxicity was observed against the Vero cell line at all concentrations tested (7.81–1000 µg.mL<sup>−1</sup>), and low cytotoxicity against the HT-29 tumor line (7.81–31.25 µg.mL<sup>−1</sup>), thus showing promising results for bioapplications.</div></div>","PeriodicalId":397,"journal":{"name":"Nano-Structures & Nano-Objects","volume":null,"pages":null},"PeriodicalIF":5.4500,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nano-Structures & Nano-Objects","FirstCategoryId":"1","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2352507X24003123","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Physics and Astronomy","Score":null,"Total":0}
引用次数: 0

Abstract

Quantum dots (QDs) synthesized from environmentally friendly precursors associated to scalable and high-efficiency production routes are essential for nanomedicine applications. Ag2S nanocrystal is notable by antimicrobial activity, photothermal properties, and low toxicity, making it promising bioactive nanomaterial. In this work, L-glutathione (GSH) capped Ag2S and ZnSe seeds were synthesized by using a fast and environmentally friendly electrochemical method (cavity cell, graphite powder macroelectrode and aqueous medium) and tested for biological applications. Ag2S nanocrystals presented a monoclinic structure (XRD analysis). The modulation of the optical properties was carried out by varying the Ag+/S2- ratio (1:1, 2:1, and 4:1), showing a photoluminescence hypsochromic shift from 916 to 759 nm, respectively. The modulation of the optical parameters was also carried out by the synthesis of Ag2S@ZnSe core/shell nanostructures. ZnSe seeds were prepared by the same electrochemical method and added to the Ag2S solution followed by thermal treatment under reflux (10 min). Ag2S@ZnSe systems showed higher photoluminescence intensity and a hypsochromic shift of the emission band using Ag2S cores (Ag+/S2- = 1:1 and 1:2), which was associated to the formation of alloy-type structures. In the case of the Ag2S@ZnSe (Ag+/S2- = 1:4), a bathochromic shift of the emission bands can be observed, which was associated to the formation of a core/shell structure. Ag2S@ZnSe QDs were tested in antimicrobial and cytotoxicity assays, showing a minimal inhibitory concentration (MIC) equal to 512 µg.mL−1. No cytotoxicity was observed against the Vero cell line at all concentrations tested (7.81–1000 µg.mL−1), and low cytotoxicity against the HT-29 tumor line (7.81–31.25 µg.mL−1), thus showing promising results for bioapplications.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
电合成 Ag2S@ZnSe 量子点的可调光致发光,用于纳米医药应用
量子点(QDs)由环境友好型前体合成,具有可扩展和高效率的生产路线,对纳米医学应用至关重要。Ag2S 纳米晶体具有显著的抗菌活性、光热特性和低毒性,是一种前景广阔的生物活性纳米材料。本研究采用快速、环保的电化学方法(空腔电池、石墨粉大电极和水介质)合成了 L-谷胱甘肽(GSH)封端的 Ag2S 和 ZnSe 种子,并进行了生物应用测试。Ag2S 纳米晶体呈现单斜结构(XRD 分析)。通过改变 Ag+/S2-的比例(1:1、2:1 和 4:1)对其光学特性进行了调制,结果显示光致发光的低色偏分别从 916 nm 到 759 nm。光学参数的调制还通过 Ag2S@ZnSe 核/壳纳米结构的合成实现。采用相同的电化学方法制备 ZnSe 种子,并将其加入 Ag2S 溶液中,然后在回流条件下进行热处理(10 分钟)。Ag2S@ZnSe 系统显示出更高的光致发光强度,使用 Ag2S 内核(Ag+/S2- = 1:1 和 1:2)的发射带出现了低色度偏移,这与合金型结构的形成有关。在 Ag2S@ZnSe(Ag+/S2- = 1:4)的情况下,可以观察到发射带的浴色偏移,这与形成核/壳结构有关。对 Ag2S@ZnSe QDs 进行了抗菌和细胞毒性测试,结果显示其最小抑菌浓度(MIC)为 512 µg.mL-1。在所有测试浓度(7.81-1000 µg.mL-1)下,均未观察到对 Vero 细胞系的细胞毒性,而对 HT-29 肿瘤细胞系的细胞毒性较低(7.81-31.25 µg.mL-1),因此显示出良好的生物应用前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Nano-Structures & Nano-Objects
Nano-Structures & Nano-Objects Physics and Astronomy-Condensed Matter Physics
CiteScore
9.20
自引率
0.00%
发文量
60
审稿时长
22 days
期刊介绍: Nano-Structures & Nano-Objects is a new journal devoted to all aspects of the synthesis and the properties of this new flourishing domain. The journal is devoted to novel architectures at the nano-level with an emphasis on new synthesis and characterization methods. The journal is focused on the objects rather than on their applications. However, the research for new applications of original nano-structures & nano-objects in various fields such as nano-electronics, energy conversion, catalysis, drug delivery and nano-medicine is also welcome. The scope of Nano-Structures & Nano-Objects involves: -Metal and alloy nanoparticles with complex nanostructures such as shape control, core-shell and dumbells -Oxide nanoparticles and nanostructures, with complex oxide/metal, oxide/surface and oxide /organic interfaces -Inorganic semi-conducting nanoparticles (quantum dots) with an emphasis on new phases, structures, shapes and complexity -Nanostructures involving molecular inorganic species such as nanoparticles of coordination compounds, molecular magnets, spin transition nanoparticles etc. or organic nano-objects, in particular for molecular electronics -Nanostructured materials such as nano-MOFs and nano-zeolites -Hetero-junctions between molecules and nano-objects, between different nano-objects & nanostructures or between nano-objects & nanostructures and surfaces -Methods of characterization specific of the nano size or adapted for the nano size such as X-ray and neutron scattering, light scattering, NMR, Raman, Plasmonics, near field microscopies, various TEM and SEM techniques, magnetic studies, etc .
期刊最新文献
Tunable photoluminescence of electrosynthesized Ag2S@ZnSe quantum dots for nanomedicine applications Influence of morphology on thermal properties of Mn3O4 nanoparticles - A thermal lens study Recent advancements in selenium nanoconstructs as a potential carrier in cancer therapy The past to the current advances in the synthesis and applications of silica nanoparticles Nano-sized SnO2: Planar defects or particle shape anisotropy?
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1